@DouganLab

Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis https://xitter.cf/t.co/8P66UdKcLf https://xitter.cf/t.co/Wa9filzfVh… views my own

 Melbourne, Australia
scholar.google.com/citations?user=zOiG8hsAAAAJ&hl=en
Joined April 2015
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Dougan Lab retweeted
ShorterLab@ShorterLabOct 18
Mechanistic classification of the AAA superfamily with protein language models biorxiv.org/content/10.64898…

Mechanistic classification of the AAA superfamily with protein language models

The A TPases A ssociated with various cellular A ctivites (AAA) are a class of proteins with diverse structure-function relationships whereby conserved 3-dimensional architecture is employed in...

biorxiv.org
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Dougan Lab retweeted
ShorterLab@ShorterLabJul 28
Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation | PNAS pnas.org/doi/10.1073/pnas.25…

Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-termi...

TAR DNA binding protein 43 (TDP-43), a key protein linked to ALS pathology, undergoes phase separation and forms functional assemblies via condensa...

pnas.org
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GID4-Recruiting PROTACs for BRD4 Degradation Overcome Resistance Driven by CRBN and VHL Deficiency | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

GID4-Recruiting PROTACs for BRD4 Degradation Overcome Resistance Driven by CRBN and VHL Deficiency

Abstract. Despite the identification of over 600 E3 ligases, current proteolysis-targeting chimeras (PROTACs) predominantly rely on CRBN and VHL. Recently,

pubs.acs.org
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Overturn this. 🧏‍♂️ #USABEL
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Online Now: Design principles of a membrane-spanning ubiquitin ligase dlvr.it/TSkgS6
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Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability | JACS Au pubs.acs.org/doi/10.1021/jac…

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability

Abstract. Proteolysis-targeting chimeras (PROTACs) are promising next-generation therapeutics for the degradation of disease-associated proteins. However,

pubs.acs.org
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Our recent work on mechanism of disassembly and reassembly of oligomeric proteins is now published in ACS Biochemistry. doi.org/10.1021/acs.biochem.…

Concerted Deoligomerization and Nonfunctional Reassembly of the Hexameric Proteasomal ATPase Mpa...

Abstract. Mycobacterium tuberculosis Mpa is an AAA+ ATPase that unfolds and translocates substrate proteins during proteasomal degradation. Mpa spontaneous

pubs.acs.org
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Online Now: Mitochondria as sources and targets of cellular signaling dlvr.it/TQcy31
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Dougan Lab retweeted
ShorterLab@ShorterLabJan 27
Metabolically regulated proteasome supramolecular organization in situ: Cell cell.com/cell/fulltext/S0092…

Metabolically regulated proteasome supramolecular organization in situ

Structural steps along the assembly of proteasome storage granules—membraneless organelles that form in response to metabolic shifts in yeast—are visualized inside cells by cryo-electron tomography....

cell.com
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Online Now: Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors dlvr.it/TQbRjK
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In @eLife: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC) doi.org/10.7554/eLife.101496 – at Philadelphia, PA

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for...

elifesciences.org
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Dougan Lab retweeted
ShorterLab@ShorterLab6 Nov 2025
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1: nature.com/articles/s41594-0…

Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1

Nature Structural & Molecular Biology - The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and...

nature.com
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Dougan Lab retweeted
MITOtalks@MitOtalks4 Nov 2025
How's your juggling act? Mitochondria also have one, and the MITOtalk this week will be all about it. See you there?
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Online Now: Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins dlvr.it/TNnWzh
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Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria pnas.org/doi/abs/10.1073/pna…

Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria...

Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacter...

pnas.org
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The yeast peroxisomal proteome at absolute quantitative scale biorxiv.org/content/10.1101/…

The yeast peroxisomal proteome at absolute quantitative scale

Peroxisomes are dynamic organelles vital for lipid metabolism and redox homeostasis. In Saccharomyces cerevisiae , the expression of peroxisomal proteins is tightly regulated in response to metabolic...

biorxiv.org
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Dougan Lab retweeted
Kato@oxkawaka2 Oct 2025
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota 別グループからも出てる nature.com/articles/s41564-0…

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota

Nature Microbiology - Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large...

nature.com
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And now for something completely different in co-translational targeting dlvr.it/TNTx4Z
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Dougan Lab retweeted
ShorterLab@ShorterLab3 Oct 2025
Translation landscape of stress granules | Science Advances science.org/doi/10.1126/scia…

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

science.org
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Predictions for @NobelPrize in Medicine 2025 : 1) Hartl and Horwich for Chaperone assisted protein folding . 2) Deisseroth and Hegemann for Optogenetics and microbial light-activated proteins .
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