Neurosurgeon, neuroscientist, human and dog mom, social media account manager for my dog. @NeurosurgUCSF
San Francisco, CA
Joined October 2019
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We are hiring! The Wang Lab is looking for a postdoctoral fellow with strong computational neuroscience/neural engineering background who is interested in working on human translational neuroscience projects on closed loop neuromodulation! Pleas email me if interested!
Doris Wang retweeted
Dr. @DorisWangLab (@NeurosurgUCSF ) on focused ultrasound, incisionless treatment reshaping care for tremor and Parkinson's disease.
Register: sfneurological.member365.com…
#SFNS #ParkinsonsDisease #Neurosurgery
#82: Doris Wang – Adaptive DBS, the Rhythm of Walking, and Restoring Human Movement stimulatingbrains.org/?p=414…
Doris Wang retweeted
Thrilled to share our latest work in @NatureNeuro, showing a reproducible brain signature to predict and prevent attention lapses in children before they happen. A work only made possible by @GMI_Canada mentorship and collaborators @SickKidsNews.
nature.com/articles/s41593-0…
Thank you so much Shervin! Really couldn’t do it without my amazing team!!! Glad to get this work out!
Doris Wang retweeted
An automated #intracortical brain-computer interface, used at home with no researcher intervention, provides long-term and accurate restoration of #speech-based #communication and cursor-based computer usage in a person with severe dysarthria due to ALS. #BCI @NS_Card @SergeyStavisky @DrDavidBrandman
nature.com/articles/s41591-0…
Doris Wang retweeted
.@NeurosurgUCSF researchers developed a “smart” brain implant for patients with Parkinson’s that adjusts stimulation in real time, improving gait. "This is an important step toward a new generation of brain therapies," @DorisWangLab tells @nbcbayarea. ucsfh.org/4vcIwTD
Doris Wang retweeted
A randomized crossover study shows that gait-phase synchronized #adaptive deep brain stimulation is feasible, safe, and reduces falls compared to continuous #stimulation in #ParkinsonsDisease. #DBS #PD.
nature.com/articles/s41591-0…
Great work from @DorisWangLab, @UCSFneurosurg, @kennethlouiephd.
Doris Wang retweeted
New in @NatureMedicine, @DorisWangLab shows that distinct left- and right-leg swing biomarkers can drive DBS that changes on a sub-second timescale with each step. A major advance toward movement-driven, precision-timed neuromodulation for #Parkinsons. nature.com/articles/s41591-0…
We're excited about what comes next as we continue developing therapies that are personalized, adaptive, and responsive to real-world behavior.
Paper:
nature.com/articles/s41591-0…
This study would not have been possible without an incredible multidisciplinary team led by Dr. Ken Louie!
Thank you to everyone, especially our patients, who made this work possible!
These findings suggest that future neuromodulation therapies may work with the brain's natural movement rhythms rather than delivering the same stimulation at all times.
In our feasibility study, gait-phase adaptive DBS:
✅ Improved gait symmetry
✅ Reduced walking variability
✅ Improved walking performance
✅ Was associated with fewer falls
Unlike traditional adaptive DBS approaches that respond to global motor states over seconds to minutes, this system operates on a sub-second timescale.
It continuously "listens" to movement and adjusts stimulation accordingly.
These signals were used to drive a new form of adaptive DBS.
As patients walked, stimulation automatically adjusted between the left and right hemispheres in synchrony with each step.
To answer this question, we implanted research neurostimulators capable of recording brain activity while patients moved naturally.
We identified personalized neural biomarkers associated with left and right leg movement.
For decades, DBS has delivered continuous stimulation regardless of what a patient is doing.
But walking is dynamic. Every step requires precise coordination between the brain, both legs, and balance systems.
We wondered: could DBS adapt in real time to walking itself?