Just out 📢 in @AJHGNews 🧬 Bi-allelic variants in POPDC2 identified in 4 families with sinus node dysfunction, AV conduction defects, and hypertrophic cardiomyopathy. 🫀Mechanism? Impaired cAMP-dependent regulation of TREK-1 potassium channels, disrupting cardiac pacemaking & conduction. 📉 Variants not associated with clinical outcomes in heterozygous state — suggesting recessive inheritance & limited need for follow-up in carriers. @bowinkel75 @DoktorRand @HenningBundgaa1 @GhouseJonas @rafik_tadros @ArthurWilde5 @cbezzina1 @NajimLahrouchi doi.org/10.1016/j.ajhg.2025.…

RigsHeart at day 2 of #NBCC2025 💫 We are proud to share that 2 outstanding abstracts from @RigsHeart are featured at the Doctors Abstract Competition! Congratulations to @Chaoqun_Z & @DoktorRand for “Genetic determinants of cardiac diastolic function and dysfunction” and to @HaversEva for “Polycystic Ovarian Syndrome and Long-Term Risk of Acute Myocardial Infarction and Ischemic Stroke.” Exceptional work in advancing cardiovascular research 👌

Dr. @DoktorRand just revealed common genetic variants influence the risk of amiodarone-induced hypothyroidism. #Pharmacogenetic screening might prove useful to envoke safer use of amiodarone! 🧬💊 #DCS_ECS23 @cardio_dk