MD, PhD. Focus: Acute cardiac care | Immense sports enthusiast.
København, Danmark
Joined September 2015
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Laust Obling retweeted
After out‐of‐hospital cardiac arrest, a higher mean arterial pressure increases oxygen delivery but has a smaller effect on oxygen consumption. Focus on blood pressure may improve patient outcomes. #AHAJournals @laustemil @DoktorMeyer @JohannesGrand ahajrnls.org/4e9yoS5
Laust Obling retweeted
Pupillometry after #OHCA, substudy of BOX trial
👁️ thresholds of pupillary light reflex < 4% & Neurological Pupil index ≤ 2 predict unfavorable neurological outcomes, 0% FPR
👁️ combined with NSE > 60 μg/L ⬆️ its sensitivity without ⬆️ false positives
🔓 rdcu.be/dRGr7
Laust Obling retweeted
🚨 PhD defence 🚨
Dr. @laustemil is defending his PhD thesis “Steroid as anti-inflammatory and neuroprotective agent following resuscitated out-of-hospital cardiac arrest -STEROHCA - a randomized trial"
Time: 12 Aug. 2024, 14:00
Place: Panum, Henrik Dam aud, 7.15.92
@CHassager
Laust Obling retweeted
In the subgroup of patients with heart failure from a trial of blood pressure targets after cardiac arrest, higher targets increased heart rate but did not alter cardiac index or mortality @JohannesGrand @RigsHeart @laustemil @JosiassenJakob #AHAJournals ahajrnls.org/3RwdK6m
Laust Obling retweeted
TOP, MUST-READ CARDIAC ARREST TRIALS OF 2023 🫀⚡️
We summarized in this infographic 4 important multi-center RCTs published in 2023 in the fields of cardiac arrest and CPR
Concomitantly published with a concise review in @ResusJournal
🔗 sciencedirect.com/science/ar…
🧵1/4
#FOAMcc
Laust Obling retweeted
🧠 Early methylprednisolone in comatose #OHCA patients: may improve outcome?? STEROHCA RCT on 🚑 prehospital single high-dose IV (250 mg) vs placebo
Full results #FOAMcc on @yourICM
🔓 rdcu.be/dqJU7
Editorial
🔓rdcu.be/drREl
⬇️ Below visual abstract
🚑 Exciting STEROHCA results! 📊 Prehospital high-dose glucocorticoid treatment significantly reduces norepinephrine use in comatose OHCA patients (p = 0.02). 📈 Additionally, the glucocorticoid group exhibited higher MAP and lower VIS/MAP ratio.
Link: rdcu.be/dwGzR
Laust Obling retweeted
🔥Giving steroids after #OHCA? Pathophysiology of post-CA syndrome features I/R injury & release of high levels of inflammatory cytokines. It would make sense to provide anti-inflammatory agents early after ROSC
🔓rdcu.be/drREl
On STEROHCA RCT
🔓rdcu.be/dqJU7
1/1
Great editorial just published in Intensive Care Medicine, @yourICM, about the use of steroids after out-of-hospital cardiac arrest.
This ensuing discussion is important in the aftermath of our recently published findings in the STEROHCA trial.
link.springer.com/article/10…
2/2
Link to the original paper with the main findings from the STEROHCA trial:
link.springer.com/article/10…
Laust Obling retweeted
🧠 Early methylprednisolone in comatose #OHCA patients: may improve outcome?? STEROHCA 🇩🇰 RCT
🚑 prehospital single high-dose IV (250 mg) vs placebo resulted in
💉substantial decrease in IL-6 after 24h
💉no effect on NSE levels during first 72h
#FOAMcc
🔓 rdcu.be/dqJU7
Laust Obling retweeted
WHAT A #MILESTONE!!
After JUST 11 months - today the last patient was randomized in the PULSE-MI trial! 🫀🚑
The last FU will be completed in January 2024! ✅
We are excited to share the results on the trial in the beginning of 2024! 🫀 #CardioTwitter #RCT @RigsHeart
Laust Obling retweeted
#Thread 1/4
Can early anti-inflammatory #steroid treatment in the pre-hospital setting of a resuscitated #OHCA mitigate the progression of post-cardiac arrest syndrome? 😵🫀
The #STEROHCA trail chaired at @Rigshospitalet is about to reveal its results! #CardioTwitter – at Copenhagen, Denmark
Laust Obling retweeted
50 patients (12%) have now completed the 3-months #CMR. A total of 211 patients with #STEMI have now been included in just 4 months!! 🫀
The trial is powered to find a 20% reduction in final infarct size -> 378 3-months #CMR are needed! @RigsHeart @JasmineMMadsen @laustemil #RCT
Laust Obling retweeted
After just 3 months, 214 patients have been included in the PULSE-MI trial! Today, the fifth patient will undergo the 3 month follow-up CMR to evaluate final infarct size 🫀 @rigsheart #RCT
Laust Obling retweeted
Does prehospital administration of pulse-dose methylprednisone reduce final infarct size in #STEMIpatients? The #RCT have been running for almost 2 months and we have included 155 patients. Now, the first patients are being called in for the 3-months follow-up #CMR🫀@RigsHeart
Laust Obling retweeted
1 month=76 patients included!😮
This setup is a logistic challenge but it works!! All the ambulance staff in @RegionH and @regionsjaelland, and the doctors at @Rigshospitalet are doing an amazing job including patients every day! We have now included 19% of the patients! 🫀 👏