Cancer biologist interested in the tumor microenvironment, cell-cell interactions, signal transduction, protein kinases, and kitty cats
Cologne, Germany
Joined April 2012
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Beyond happy to see our latest publication out in @Hemasphere_EHA
onlinelibrary.wiley.com/doi/…
We show that all human macrophage feeders activate JAK/STAT and MAPK signaling in CLL cells to support leukemic persistence.
Grateful for our team effort and the SFB-1530 for support
Hien Nguyen retweeted
Time for a quick read? Check out our perspective on TiME interactions in CLL and RT! Fun discussions with Phuong-Hien Nguyen and Alex Vom-Stein!
frontiersin.org/articles/10.…
🆕🆕🆕Preprint from our labs
doi.org/10.1101/2025.02.13.6…
In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance, and their impact on the transcriptional profiles of CLL cells
Hien Nguyen retweeted
Beyond excited that the first paper of my PhD journey is out in @NeuroOnc today, reviewing the brain metastatic immune microenvironment.
Super grateful for the great collaborative effort, particularly the guidance of @DimHien and @RolandGoldbrunn !
academic.oup.com/neuro-oncol…
thrilled to share our accepted Review in @NeuroOnc. The 1&only @luca_david_ kicks off his PhD with a comprehensive overview of the Immune Landscape in Brain Metastasis. So grateful for the support from all partners, esp. the guidance of @RolandGoldbrunn.
academic.oup.com/neuro-oncol…
Hien Nguyen retweeted
Excited to share our @lewis_ri_ @HallekMichael perspective on double-refractory (2R) #CLL, now in @BloodJournal. 2R pts are a growing challenge with poor outcomes. We outline the current landscape and explore targets in the tumor microenvironment. #CLL
doi.org/10.1182/blood.202302…
Hien Nguyen retweeted
Great pleasure to present our work on the role of RIPK1 in beta cell survival! Congratulations @onayyveli for this amazing piece of work. Thanks a lot to our collabs especially to @CardozoKupper
@sfb_1403 @CECAD_ @UniCologne
🔬 Second paper from our lab!
RIPK1 is not essential for cell death regulation in pancreatic β-cells. These cells bear a unique mechanism to resist TNF-induced cell death, which might depend on the anti-apoptotic cFLIP.
Check out the full study: sciencedirect.com/science/ar…
Hien Nguyen retweeted
As promised, the second issue of our CLL review series is out now at Seminars in Hematology. Check it out if you are interested in CLL biology and mouse models!
sciencedirect.com/journal/se…
Hien Nguyen retweeted
JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma | Science science.org/doi/10.1126/scie…
Hien Nguyen retweeted
For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome.
nature.com/articles/s41586-0…
📢Our latest review is online! We discuss how macrophages influence CLL progression and frontline therapy response, a topic initiated and contemplated by our youngest lab member @hjestrabek. Such a great joy for me to work with the new Gen of 2000s 🎉
sciencedirect.com/science/ar…
Hien Nguyen retweeted
Incredibly proud of our first paper in @cddpress on pMLKL-s345 . Congrats @c_kelep for driving this project. BIG Thank you to all our collaborators @ale_annibaldi81 @Linkermann_Lab @Walczak_Lab @PardoGalvez_Lab for your incredible support and input. nature.com/articles/s41418-0…
My huge congratulations to Sumiya, Shaista and Sanjay for this very nice publication!! We are so thankful to be involved and it was so lovely to be able to follow how the challenge of encapsulating hydrophobic drugs such as kinase inhibitors could be tackled elegantly here.
Addressing the challenge of hydrophobic drug delivery! Our latest research on lipid-coated silica nanocarriers showcases a novel approach to prolonging the release of hydrophobic drugs, promising enhanced treatment efficacy with controlled delivery🧬💊 pubs.rsc.org/en/content/arti…
Hien Nguyen retweeted
Thrilled to share our characterization of the human tyrosine kinome.
Try out the public website: kinase-library.mit.edu/home
Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson!
nature.com/articles/s41586-0…
Hien Nguyen retweeted
📢Open position for Technical Assistant at #IBMG
I am looking for the building blocks of my lab at @StuttgartUni. Interested? please apply here 🤩
stellenwerk.de/stuttgart/job…
@peltzer_lab @srcsb
#IBMG #SRCSB #openposition #Technician
Hien Nguyen retweeted
And a special thanks to @FabrizioMavilia and @vomSteinA #ESHYOUNGREPORTERS, for lively reporting this conference from a scientific perspective!
#ESHCLL2024 #ESHCONFERENCES #HAEMATOLOGY #HEMATOLOGY #leusm #CLLsm
#ESHCLL2024: thank you so much Jennifer Brown, Paolo Ghia, @HallekMichael & all faculty for a superb meeting in Vienna & to all participants for engaging so actively with questions & comments!
Don't miss upcoming ESH Conferences visit ➡ esh.org
#ESHCONFERENCES
Hien Nguyen retweeted
A great way to close the #ESHCLL2024 Day1: a friendly get together, Mentored Poster Walks & informal scientific exchange between colleagues & friends. Thank you to all Poster Presenters & to H. Nguyen @etenhacken @carsten_niemann & A. Rawstron for your mentorship! #ESHCONFERENCES
Hien Nguyen retweeted
Please RT and register: West German Lymphoma Symposium @HamatologieUk @UniklinikEssen @MedEssen @unidue @dgho_eV #sfb1530 lymphoma-symposium.de/
A beautiful wrap-up for this year! Please check out our (pre-proof) review about the role of the tumor microenvironment in CLL pathogenesis. A very nice piece of work from @vomSteinA @HallekMichael
sciencedirect.com/science/ar…