Tanvi Dhere,MD retweeted
This thread is a great summary of what we know so far for the anti-TL1A antibodies for the treatment of #IBD
Once we see the phase 3 data on these molecules we’ll have a better sense of how they fit in the algorithm
Replying to @DCharabaty @MondayNightIBD @sanofi @vipuljairath @PeyrinBiroulet @silvio_silvio75 @doc_ibd @MSHS_IBDCenter @DrJessicaA @AndresYarur @AdamEhrlichMD @AdamFayeMD @Badr_AlBawardy @ShomronH @BenClickMD @BrunoSilva_MD @Dana_Lukin @dr_fcalderaibd @KerbageAnthony @pdxIBD @DisneyBen @UKGastroDr @joshsteinbergMD @DSTEINGIMD @DrMohdZein @DiscoverIBD @EdwardLoftus2 @EdBarnesMD @FITWITMD @fudmanMD
5/#MondayNightIBD
RELIEVE UCCD 📊Wk 14 outcomes in #Crohns
🔦Endo Response (≥50% ↓ SES-CD)
48% (900mg)/ 26% (450mg) DUVA vs 13% PBO
Δ33% PP >0.99 | Δ13% PP 0.94
🩺Clinical Remission (PRO2)
37%/37% DUVA vs 26% PBO
Δ10% PP 0.87 (both doses)
SAIA Members come together for #DressinBlueDay to mark #CRCAwarenessMonth 💙🩵
45 is the new 50! If you were born in 1980-1981 and haven’t gotten your screening #colonoscopy yet, please discuss with your doctor🙏🏽
This March, join us to #BreakTheSilence and shatter the stigma around #ColorectalCancer and colonoscopies! 💥 🙌🏽
Tanvi Dhere,MD retweeted
Colorectal cancer is now the #1 cause of cancer death among individuals under 50
jamanetwork.com/journals/jam…
Tanvi Dhere,MD retweeted
Big news! Something that clinically makes sense from @US_FDA
RINVOQ: (NEW ADDITION) If TNF blockers are clinically inadvisable, patients should have received at least one approved systemic therapy prior to use of RINVOQ.
Tanvi Dhere,MD retweeted
Replying to @PSamikshaMD @MondayNightIBD @IBDBen @GCalderonMD @ReezwanaCMD @DavidBruiningMD @HorstIBDDoc @ManuelBragaMD @P_DeepakIBDMD @Realcecum @SophieBalzoraMD @ptandonGI @Y_ECCO_IBD @SultanShazi @GloverQuarshie @Adel_Hajj_Ali @gnioannou @KiwanGIDoc @DrMarinaKimP @SpyrosZouridis @HBoudaher @EricaBeckerMD @IBD_FloMD @MN_GIMD @RolnikDaniel @NEJM @doclauravater @HolubarStefan @jordanmaloneDO @BakkorMd @Alibutt1995 @VijaySAre9 @karl_akiki @SantaellaMD @JHashashMD @SunandaKaneMD @keljurdi @HamdehShadi @PriankaGajula @EricYoonMD @DouglasAdlerMD @HarshitKharaMD @DrJFeuerstein @clivejmiranda @drkeithsiau @AdamFayeMD @EdBarnesMD @NayantaraCoelho
6/💡Contraception: LARC preferred; avoid estrogen b/o VTE risk
⚡Pre-pregnancy Counseling:
✅Stable steroid-free objective remission 3–6 mo before conception
💊Stop teratogens: MTX, JAKi, S1Ps
💊Educate on safety of 5asa, thiopurines, biologics
🩺Vaccines, folate, optimize🥗
Tanvi Dhere,MD retweeted
Replying to @PSamikshaMD @MondayNightIBD @IBDBen @GCalderonMD @ReezwanaCMD @DavidBruiningMD @HorstIBDDoc @ManuelBragaMD @P_DeepakIBDMD @Realcecum @SophieBalzoraMD @ptandonGI @Y_ECCO_IBD @SultanShazi @GloverQuarshie @Adel_Hajj_Ali @gnioannou @KiwanGIDoc @DrMarinaKimP @SpyrosZouridis @HBoudaher @EricaBeckerMD @IBD_FloMD @MN_GIMD @RolnikDaniel @NEJM @doclauravater @HolubarStefan @jordanmaloneDO @BakkorMd @Alibutt1995 @VijaySAre9 @karl_akiki @SantaellaMD @JHashashMD @SunandaKaneMD @keljurdi @HamdehShadi @PriankaGajula @EricYoonMD @DouglasAdlerMD @HarshitKharaMD
5/⬆️Risk of active disease in pregnancy if:
✅🔥within 6 months prior to conception
✅🔥in prior🤰
✅Ulcerative colitis (UC)
💎Ensure stable steroid-free remission for 3–6 months before conception
💎Use & continue effective IBD therapy to optimize🤰outcomes
#MFM #ObgynTwitter
Tanvi Dhere,MD retweeted
Do we really need to stop PPI before testing for H. pylori?
link.springer.com/article/10…
Tanvi Dhere,MD retweeted
Replying to @MondayNightIBD @DCharabaty @abbvie @JanssenUS @TakedaPharma @nloganmd @fudmanMD @DrJordanAxelrad @DhereMdEmory @SchwartzbergMD @HolubarStefan @EdwardLoftus2 @ibdgijami @PMyrelid @AdamFayeMD
70M pancolitis+PSC, on ADAL, o/w healthy
🔦Surv CLN: depressed lesion in sigmoid (📸 👆🏽)
🔬Bx of the lesion: high grade dysplasia. Random bx proximal rectum: indefinite dysplasia, distal rectum: nml
What do you recommend?
🔑TPC= total proctocolectomy; IRA= ileorectal anastomosis
38%TPC + IPAA
33%TPC + End ileostomy
17%TC + IRA + close🔦
12%Left hemi✂️+ostomy+surv🔦
93 votes • Final resultsThank you @lsuhs_gastro for a great conf. Proud of our previous Emory GI trainees including @DachaSunil and #RushikeshShah on teaching us about advanced endoscopy. Thank you #QiangCai for the invitation. Your humility, knowledge, and mentorship continue to inspire me.
Tanvi Dhere,MD retweeted
Replying to @MarcelYibirin @MazenAlmasry4 @MondayNightIBD @bbuchbinderMD @ChaftJamie @gregfischer72 @margare89055458 @MyriamChalabi @GeneCollector @drkeithsiau @ArndtVogel @RyanNipp @CarlKayMD @realDoctorUgo @AmirGhaffariMD @AmyBugwadia @Gastrolegacy1 @TheGastrologer @RestelliniS @MbarbaraMD @GlassnerKerri @sang_hyoung @MLutzMD @KralJan @NabilQuraishi @RashidLui @JVG_GIMD @h_sokol @evanlipson @DeepakGIQuality @Ryansmith_MD @JPAchkarMD @Ari_G_MD @IBDimmunology @ReezwanaCMD @DhereMdEmory @waqqasafif @BattatMD4IBD @ibdgijami @nloganmd @ibdseb @GI_JeffMD @KajaliMishra @DrVinnyCheung @AndrewProthero6 @PKlenermanLab @sarah_sasson @KBollinMD @FunchainMD @DrJNaidoo
#PostB2B #IBDPoll1️⃣
🆓#CME👉🏽 bit.ly/ICIsB2Bpost
57y/o w metastatic melanoma started ipilimumab + nivolumab 7 weeks ago. Now in ER w 4 days of non-bloody diarrhea (7 loose BM/day), abdopain, malaise. Stool studies pending, CT scan: pancolitis.
14%CMV colitis
0%C. difficile colitis
86%ICI-induced colitis
0%Ischemic colitis
22 votes • Final results Tanvi Dhere,MD retweeted
Replying to @MondayNightIBD @waqqasafif @IBDimmunology @BattatMD4IBD @GI_JeffMD @valeorillac5 @ibdseb @fudmanMD @fgomollon @SaraElOualiMD @Waseem_AhmedMD @joshsteinbergMD @GI_PharmD @DocSanchu
2/ #IBDAlgo @MondayNightIBD @DCharabaty
Phenomenal tweetorial🧵, convos💬 & webinar🎥 on efficacy, safety & role of anti-#IL23p19 in UC & CD
✅Tweetorial & Webinar for review🔗in next tweet
✅Practical info on use of this new MOA👇🏽
@marc_cram @pash22 @ign76 @RestelliniS
Tanvi Dhere,MD retweeted
📣Join us now for a convo led by @IBDimmunology @DCharabaty
With 🆕MOAs in our 🧰
What’s next for #ulcerativecolitis after TNFi ?
How do you ⚖️ efficacy/ safety/ comorbidities / age?
🗳️IBDPoll👇🏽
💬Share your thoughts
Supported by educational grant @EliLillyandCo
Tanvi Dhere,MD retweeted
We've come together for #DressinBlueDay, the first Friday of #CRCAwarenessMonth! 🎉
Join SAIA as we stomp out the #stigma!
#45isthenew50 so if you haven’t gotten a screening #colonoscopy yet, please talk to your physicians 💥🙌🏽
Tanvi Dhere,MD retweeted
Excited to announce results of our #ADDapt trial
After 6 years and the help of 154 people with #CrohnsDisease we prove that restricting #emulsifiers improves disease
Award winning presentation from @AaronBancil at #ECCO25
Excited for next steps to help people with Crohns
Tanvi Dhere,MD retweeted
🍁Part 5 of our fall series: A better future in #Crohns
✅#IBDTweetorial🧵 w/ #DrMarlaDubinsky & @DCharabaty
🔮New Treatment 🎯 on the horizon: transmural healing & PROs
🆓#CME bit.ly/CrohnsPROs
Support by an educational grant from @EliLillyandCo
📌Where r you in🩺
55%IBD specialist
17%General GI, CRSurgeon
26%Trainee, Fellow
2%APP,PharmD,GastroPsych..
58 votes • Final resultsThank you @JHaydek for the great summary points!
🚨AGA New Guideline Alert🚨
🔗gastrojournal.org/article/S0…
▶️AGA Living Guideline: Pharmacological Management of Moderate-Severe Ulcerative Colitis
I’ll break down its 14 recommendations down over the next 7 tweets 🧵 👇
#AGA #GI #UC #IBD #MedTwitter
1/9
Tanvi Dhere,MD retweeted
I always learn from⭐️ @ibdgijami
#Negotiating & get your dream job
✅Build a network
✅Know your value
✅Ask for what you want & know your non-negotiable
✅Negotiate more than a salary👇🏽
✅Involve a lawyer & have everything in writing
@AmerGastroAssn #WomenInGI workshop
Tanvi Dhere,MD retweeted
⏰Make a 🌟splash🌟 on back to school night this fall !
🗞️Submit your work by Nov 1 to #CC360 @IBDJournals Special series
🎯#EIM in #IBD
🔺From “classical” (joints, skin,eyes..) to under-recognized EIM (orofacial, dental, CV, fatigue, kidney stones..)
academic.oup.com/crohnscolit…
Tanvi Dhere,MD retweeted
If you are an “IV believer” & concerned about IV ↪️ SQ IFX/VDZ
✅SUCRA👇🏽of maintenance data in TNFi naive pts
⚠️IFX 120mg SQ q2w> IV 5-10mg/kg q8w for
🔺Clinical Remission in Crohns & UC
🔺Mucosal healing in UC
⚠️VDZ 108mg SQ q2w >IV q8w for CR in UC & ~for mucosal healing
💭?
Comparative Efficacy of Subcutaneous and Intravenous Infliximab and Vedolizumab for Maintenance Treatment of TNF-naive Adult Patients with #IBD: A Systematic Literature Review and Network Meta-analysis.
pubmed.ncbi.nlm.nih.gov/3849…
@PeyrinBiroulet @peter_bossuyt @EdwardLoftus2
Tanvi Dhere,MD retweeted
📣#CFP: #GI #Rheum #Derm & al. Submit your original research on #EIM in #IBD @IBDJournals
🔺Pre-symptoms biomarkers
🔺Dx
🔺Treatment
Of “classical” (joints, eyes..) or “underevaluated” EIM (orofacial, dental, cardiovascular, fatigue, kidney stones..)
🔗academic.oup.com/crohnscolit…



































