@DevermanLab
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Engineering viral vectors for gene therapy @stanleycenter @broadinstitute
Cambridge, MA
Joined February 2019
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DevermanLab retweeted
📣🎉New pooled library! This screening library from George Church's lab contains all possible single codon substitutions, deletions, and insertions in the AAV2 cap gene.
hubs.la/Q022s6pR0
DevermanLab retweeted
iCAP-BI-28-KanR
Depositor: @DevermanLab
Purpose: RepCap for AAV production
addgene.org/203532/
We have released a preprint “Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions”.
We developed gene delivery vectors with known mechanisms of action & predictable tropisms by targeting AAVs to specific proteins.
tinyurl.com/2ndsuvp6
We believe this strategy will accelerate the development of AAV gene delivery vectors that bind defined targets on different disease-relevant cell types with high specificity and across species to enable translation from preclinical models to investigational human gene therapies.
This work was made possible by our @StanleyCenter @broadinstitute team:
Helen Huang
@atchen_
Ken Chan
Hikari Sorensen
Andrew Barry
@azari_ba
Thomas Beddow
Qingxia Zheng
Binhui Zhao
Isabelle Tobey
@Fatma_zahra_Eid
@ayjchan
DevermanLab retweeted
Early-career scientists: We want to fund your pilot studies in #genetherapy & #celltherapy!
ASGCT Members can apply for one of six $100,000 #CareerDevelopment awards by Aug. 1. Learn more and apply today! bit.ly/3w8vp6m
We’re thrilled to have Andy join our team!
ICYMI: Read all about Andy’s ‘10 amazing story - from successful robotics engineer to a machine learning scientist working on gene therapy at the @broadinstitute in @DevermanLab. olin.edu/articles/robotics-l…
Come see how we are conceptually upending protein evolution approaches by building a machine learning-driven atlas to efficiently identify AAV capsids with multiple desired traits (improved tropisms + manufacturability).
Talk abstract 1201
May 19, 11:45am
@ASGCTherapy #ASGCT22
Ken Chan from the Deverman lab @broadinstitute @StanleyCenter is presenting data on several AAVs that can efficiently deliver genes to the brain and spinal cord.
Our talk is on May 19, 10:45am
@ASGCTherapy #ASGCT22
Abstract 1197
DevermanLab retweeted
Excited to introduce @DevermanLab machine learning guided platform that simultaneously optimizes multiple traits in AAV capsids valuable to gene therapy. #ASGCT22 May 19, 11:45am
