@DePaceLab
 Boston, MA
depace.med.harvard.edu
Joined March 2012
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  • Following146
  • Followers1.2K
4Media
Thrilled to share our new (unredacted) report in @sciencemagazine with evidence for cooperation influencing outcomes! Led by Caleb Bashor & @nikitpatels, we built cooperative TF assemblies and showed how they enable complex signal processing in cells: science.sciencemag.org/conte…
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Excited that our review on the MZT in Drosophila is now online at Open Biology (royalsocietypublishing.org/d…). Great work from recent PhD grad Danielle Hamm.
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DePace Lab retweeted
HMS_SysBio@HMS_SysBio4 Dec 2018
Undergraduates -- apply for a Summer Internship in Systems Biology! You get to explore Harvard and do cool research while being paid. sysbio.med.harvard.edu/summe…
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Don't forget to apply to join the fabulous group of interdisciplinary students and faculty in the Harvard PhD program in Systems Biology! Deadline Dec 1. No GRE needed, application fees can be waived, stipend, tuition and health insurance included. sysbiophd.harvard.edu/prospe…
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Replying to @FORsymp
Happy to say that we will be matching the next $1000 of donations to @FORsymp! Everyone wants the standard of mentoring in academia to improve, this is a great way to start driving change. #GivingTuesday
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more evidence for the functional role of Zelda hubs in mediating transcription factor binding to their targets. Really exciting to see this line of research blossoming! biorxiv.org/content/early/20…
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Hello #ABRCMS2018 ! Come talk to us about the Harvard PhD Program in Systems Biology! We’re in the Exhibit Hall booth 812.
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DePace Lab retweeted
Sandro Baldi@5_Baldi2 Nov 2018
1/ Our work on phased nucleosome arrays in the Drosophila genome is out: cell.com/molecular-cell/full… In it, we used spectral analysis to map phased arrays throughout the genome.

Genome-wide Rules of Nucleosome Phasing in Drosophila

Patches of evenly spaced nucleosomes mark regulatory elements in the genome. Baldi et al. comprehensively map such phased arrays throughout the Drosophila genome. By reconstituting phased arrays in a...

cell.com
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DePace Lab retweeted
Berta Verd@BertaVerd29 Oct 2018
This is happening!! @yoginho, James DiFrisco and I have been funded by @EMBO and @FEBSnews to organise the "Venice Summer School: Mechanism in Development & Evolution". Check it out, spread the news and apply!!
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The role of chromatin accessibility in cis-regulatory evolution biorxiv.org/content/early/20…
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Happy to finally share this (long in progress) work with the world. Lots of hard work by @gizemkly (especially), @JLachowiec, and Ulises Rosas. Redundant and cryptic enhancer activities of the Drosophila yellow gene biorxiv.org/content/early/20…
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DePace Lab retweeted
Berta Verd@BertaVerd11 Sep 2018
It's on bioarxiv finally! In this paper we dissect a GRN into dynamical modules and use them to study the networks evovability. Give us your feedback too! It hasn't been submitted yet. @yoginho biorxiv.org/cgi/content/shor…
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Interesting study from @DePaceLab biorxiv.org/content/early/20… Revisiting a 1989 classic from Dreiver et al nature.com/articles/340363a0 by applying quant analysis to test whether gene expression pattern controlled by Bicoid binding affinity turns out it's a little more complicated
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"Our results emphasize that the bacterial view of transcription regulation, where pairwise interactions between regulatory proteins dominate, must be reexamined in animals..."
DePace Lab@DePaceLab5 Sep 2018
Excited to share new work from @JPbiophysics & the Gunawardena lab. Mutants, knockdowns & modeling to understand how a classic Drosophila enhancer drives sharp gene expression. Spoiler : its not simple cooperative DNA binding by TFs. biorxiv.org/content/early/20…
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amazon.com/Visual-Strategies… more books like this needed. thanks @felicefrankel and @depacelab #DataScience
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New preprint @4DNucleome LADL: Light-activated dynamic looping for endogenous gene expression control. doi.org/10.1101/349340 We create synthetic architectural proteins to engineer loops on demand with blue light. Led by @MayuriRege, Ji Hun Kim. Collab with @arjunrajlab.
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Excited to share my new paper from the @HernanGGarcia lab where we uncovered how cell identity is defined in the fly embryo by visualizing transcription factor dynamics in real time using antibody fragments from Llamas. #LlamaTags cell.com/cell/fulltext/S0092…
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Underrepresented scientists are often presented as underdogs. With #BackgroundToBreakthrough we wanted to change that narrative and look at how their diverse life experiences fuel innovation. Read more about how we approached telling these stories goo.gl/atWb64
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"~10% of random 103 bp serve as promoters without evolution" and "~60% of random 103 bp need one mutation to act as promoters" xitter.cf/JamesLingford/status/9…
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Register soon for the 2018 SDB Annual Meeting! Early bird discount for registration before May 14th sdbonline.org/2018mtg_regist…
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