@5_Baldi

Postdoc in the Becker lab, working on chromatin structure and remodeling in flies, cells and the test tube

 München, Bayern
Joined March 2018
  • Tweets570
  • Following134
  • Followers186
9Media
LIDAR sees the light! Please have a look at the latest (and my first as a postdoc) preprint from the Bonasio lab. Do you think there are RNAs out there that we haven’t cloned yet? You are not alone. biorxiv.org/content/10.1101/…

A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3’ termini

Despite the numerous sequencing methods available, the vast diversity in size and chemical modifications of RNA molecules makes the capture of the full spectrum of cellular RNAs a difficult task. By...

biorxiv.org
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Huge congratulations to Peter. Well deserved!
EMBL@embl8 Dec 2022
Prof Peter Becker has been elected chair of the EMBL Council and will assume his duties in January 2023. “I am honoured to have been selected as Chair of EMBL Council. The next few years promise significant scientific progress.” embl.org/news/lab-matters/pe… 📸 @LMU_Muenchen
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We find no evidence that the formation of "transcriptional condensates" amplifies gene expression or increases transcription activation tinyurl.com/y56tof9c
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Exciting Cell paper from Hansen and Hendzel Labs!
Cell@CellCellPress15 Dec 2020
Online now! #Chromatin exists in a solid-like state to create an elastic #gel and provide a #scaffold that supports liquid-liquid #phase separation of chromatin binding #proteins bit.ly/3nlF4mI
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"At its best, science is a self-correcting march toward greater knowledge for the betterment of humanity. At its worst, it is a self-interested pursuit of greater prestige at the cost of truth and rigor." hear, hear!
Ed Yong is not here
@edyong20914 Dec 2020
🚨I wrote the Atlantic’s next cover story on the COVIDization of science. No other disease has been scrutinized so intensely, by so much combined intellect, in so brief a time. This piece is about both the victories achieved & the weaknesses exposed. 1/ theatlantic.com/magazine/arc…

How Science Beat the Virus

And what it lost in the process

theatlantic.com
Nice reflection on the protein folding breakthrough. Even if you don't care too much about the technicalities, there are some intriguing thoughts about how science progresses inside and outside of academia in the last two paragraphs
Mohammed AlQuraishi
@MoAlQuraishi8 Dec 2020
My thoughts on AlphaFold2: moalquraishi.wordpress.com/2…

AlphaFold2 @ CASP14: “It feels like one’s child has left home.”

The past week was a momentous occasion for protein structure prediction, structural biology at large, and in due time, may prove to be so for the whole of life sciences. CASP14, the conference for …

moalquraishi.wordpress.com
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We're hiring! Looking for a Lab Tech to join our new group at @embl Rome: embl.de/jobs/searchjobs/inde… Please share/RT! Thanks!

Heidelberg

EMBL's administrative headquarters in the Southern German city of Heidelberg hosts five research units and many of the laboratory's core facilities.

embl.org
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Sandro Baldi retweeted
Maxim Greenberg@maxvcg4 Dec 2020
We have had encouraging discussions in our @IJMonod forum about prioritizing not-for-profit publishing, and not being enraptured by NPG and Elsevier for our labs and for our recruitment. If this is in line with your philosophy I encourage you to apply to join us!
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Replying to @OdedRechavi
This paper was later updated to include the Gabor citation 🙈
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If you download the raw ChIP-seq data from a high profile paper there's usually about a 50% chance that it just looks like sonicated DNA. Mapped data from a Science paper today and there was just no enrichment anywhere. A giveaway is when there are no tracks shown in the paper.
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Out today - less than a week after the defence of my PhD thesis! We took a somewhat evolutionary perspective to talk about "unusual" flavors of H2A.Z remodelers. Check it out! authors.elsevier.com/c/1c5Lx…
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Please RT. We are recruiting a PostDoc to study epigenetic mechanisms. Cutting-edge methods to predict, observe, and manipulate epigenetic processes - Develop and execute the next breakthrough ideas. #epigenetics helmholtz-muenchen.de/filead….
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Happy to start this week by sharing our new story showing that the transcriptional activity of the genome can be regulated by modulating the levels of pervasive histone modifications, such as H2AK119ub1, without the need for elaborate gene-specific targeting mechanisms 1/3
bioRxiv@biorxivpreprint14 Nov 2020
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome biorxiv.org/cgi/content/shor… #bioRxiv
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Beautiful work from the Barral lab out now!
Ewerslab@ewers_helge12 Nov 2020
Data from this will go straight into my lecture, textbook data from the Barrall lab at @ETH_en Mapping bilayer thickness in the ER membrane advances.sciencemag.org/cont…
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SEQUENCING RUN NOT FINISHED YET! BUT EPIGENETIC HULK SAY ALL PEAKS IN PROMOTER!
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Thank you very much for inviting me - it was very inspiring
Patrick Cramer@mpgpresident22 Oct 2020
This year’s lab retreat took place at home and featured great talks by @5_Baldi, @dhnisz, @bulutkarslioglu, Markus Wahl and Jan-Philipp Juncker. Great variety from structure to condensates to cell transitions.
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Sandro Baldi retweeted
TheBraunLab@TheBraunLab22 Oct 2020
What happens if you put a plant histone variant into fission yeast? See our latest paper together with Fred Berger: A Synthetic Approach to Reconstruct the Evolutionary and Functional Innovations of the Plant Histone Variant H2A.W cell.com/current-biology/ful…

A Synthetic Approach to Reconstruct the Evolutionary and Functional Innovations of the Plant...

Plants evolved histone H2A.W variants with a KSPK motif, which are segregated to heterochromatin. Lei et al. show that, in yeast, synthetic H2A with a KSPK motif is distributed evenly but impacts...

cell.com
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About our #epionthespot2020 speakers: Lucia is a PhD student @TheBraunLab. She has been working on further elucidating the role of the inner nuclear membrane protein Lem2. In her talk, she will give insights into how Lem2 can regulate RNA surveillance. ➡️ bit.ly/2FPRH96
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Prospective PhD students - come join our lab @MRC_LMS! perchardelab.com. We work on questions relating to transposon regulation, early development, chromatin, nuclear organisation and more... Please RT 🧬🧪🔬findaphd.com/phds/project/ch…
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We are looking for a postdoc! Join our team in @IGBMC #Strasbourg to discover how the #nuclearpore regulates gene expression and cell proliferation in #buddingyeast. Position for up to 3 years supported by @FRM_officiel. Please RT!
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