@CuezvaLab

The role of mitochondria in human pathology. At @CBMSO_CSIC_UAM @CIBERER.

Joined June 2020
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In this study, we have investigated the alterations caused by ablation of IF1 in the colon. We demonstrated that ablation of IF1 promotes mitochondrial and Ca2+ dysfunction, activates futile ATP hydrolysis and promotes an adenosine-mediated inflammation. nature.com/articles/s41419-0…

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and...

Cell Death & Disease - IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

nature.com
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Thanks to all the colleagues that participated in the project.
Cristina Nuevo-Tapioles@CNuevoTapioles9 May 2022
I’m very happy to share the last project I had the chance to participate in @CuezvaLab at @CBMSO_CSIC_UAM! "Analysis of the metabolic proteome of lung adenocarcinomas by RPPA emphasizes mitochondria as targets for therapy" nature.com/articles/s41389-0… (1/5)
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We were very excited to see that this therapeutic approach provided better welfare to mice than cisplatin treatments, which, might result in an effective and less toxic therapeutic option for LUAD patients. Thank you @CuezvaLab and all the collaborators! @esparza_pau (5/5)
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Indeed, treatment with a fatty acid assimilation or oxidation inhibitors in combination with the recently described OXPHOS inhibitor nebivolol (see nature.com/articles/s41467-0…) significantly extended the lifespan of mice bearing lung adenocarcinomas (4/5)

Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth

Nature Communications - Targeting mitochondrial metabolism in cancer cells has shown promising therapeutic potential. Here, the authors screen FDA-approved compound library and show that the...

nature.com
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steady-state levels of mitochondrial proteins of fatty acid oxidation, oxidative phosphorylation and of the antioxidant response are independent predictors of survival and/or of disease recurrence in LUAD patients. (3/5)
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We used Reverse Phase Protein Arrays to quantify the changes in key metabolic enzymes in 128 tumors and paired non-tumor adjacent tissue of lung adenocarcinomas to profile the proteome of metabolism showing that (2/5)
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I’m very happy to share the last project I had the chance to participate in @CuezvaLab at @CBMSO_CSIC_UAM! "Analysis of the metabolic proteome of lung adenocarcinomas by RPPA emphasizes mitochondria as targets for therapy" nature.com/articles/s41389-0… (1/5)
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We are very proud to present the work: Na+ controls hypoxic signalling by the mitochondrial respiratory chain. And congratulations to Pablo Hernansanz-Agustín and all the colleges who collaborate with us. rdcu.be/b5Yo4 #mitochondria #hypoxia #redox #SodiumMatters
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Investigadores del Instituto i+12 han demostrado que el bloqueo coordinado de la actividad mitocondrial y de la angiogénesis por el nebivolol frena el crecimiento de los tumores de mama y colon. NatureCommunications imas12.es/blog/nature-commun… @Itemas
Grupo Metabolismo Energético Traslacional -JM Cuezva

ALT Grupo Metabolismo Energético Traslacional -JM Cuezva

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Great idea @CNuevoTapioles
Cristina Nuevo-Tapioles@CNuevoTapioles17 Jul 2020
So happy to share a great part of my PhD work published in @NatureComms today. We propose to target mitochondrial metabolism and angiogenesis by inhibiting beta1-adrenergic cascade to arrest tumor growth. @CuezvaLab 1/6 nature.com/articles/s41467-0…
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CuezvaLab retweeted
UCCUAM@UCCUAM17 Jul 2020
📣 Un fármaco frena el crecimiento de los tumores de mama y colon 📌 Un estudio publicado en @NatureComms prueba que un fármaco anti-hipertensivo evita el crecimiento de este tipo de tumores, abriendo las puertas a una nueva terapia contra el #cáncer ▶️ bit.ly/2OuHa3I
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A brand new @CellPressNews #paper from our former #PhDstudent Giulia Di Marco. In collaboration with @Novartis she identified new compounds that decrease #mitochondrial #calcium influx through #MICU1. Read the full paper here⬇️ pubmed.ncbi.nlm.nih.gov/3207…

A High-Throughput Screening Identifies MICU1 Targeting Compounds - PubMed

Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000...

pubmed.ncbi.nlm.nih.gov
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Hoy @CuezvaLab estaremos en la sesión de resultados 4 en #RACIBERER2020 @CIBERER hablando sobre la estrategia del reposicionamiento de fármacos en la búsqueda de terapias para pacientes de Charcot-Marie-Tooth. #CMT #mitochondria
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