@CrisprPlatform

Genetic engineering is offering many new and exciting possibilities. Keep up-to-date with the latest developments and innovations.

 Amsterdam, The Netherlands
linkedin.com/in/danielwarmerdam
Joined January 2020
  • Tweets269
  • Following191
  • Followers147
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Exciting breakthrough in genome editing! Animals, plants, fungi and viruses have programmable RNA-guided DNA nucleases (called Fazors) capable of efficient gene editing in human cells. #GenomeEditing #CRISPR #Fanzors science.org/doi/full/10.1126…

Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses

Fanzor is an RNA-guided DNA endonuclease widespread in eukaryotes and their viruses.

science.org
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Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases HELIX: a newly engineered #CRISPR-associated transposases (CASTs) with high integration product purity and genome-wide specificity. nature.com/articles/s41587-0…

Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases

Nature Biotechnology - Engineered CRISPR-associated transposases improve the purity and specificity of DNA insertions.

nature.com
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🚨Preprint alert from #CRISPRBerlin🚨: Combining different CRISPR-nucleases for simultaneous non-viral knock-in and base editing prevents translocations in multiplex-edited CAR T cells. tinyurl.com/5by84ybh Not just one but many CRISPRs are amazing. A short thread 👇🧵 1/8
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Great overview of gene editing and gene therapy approaches marching toward the clinic. Also some great insights about viral vs. non-viral delivery: nature.com/articles/s41587-0…

For hemophilia and thalassemia, a new era of ‘one-and-done’ gene therapies has arrived

Nature Biotechnology - Industry celebrates two newly approved genetic medicines, but patients with these blood disorders may face a long wait, and many will never access them because of their high...

nature.com
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Non-viral precision T-cell receptor replacement for personalized cell therapy First attempt to combine #CRISPR/Cas9-based gene editing and engineered T-cells in patients to target solid tumors (#milestone, #personalizedmedicine). nature.com/articles/s41586-0… nature.com/articles/d41586-0…

Non-viral precision T cell receptor replacement for personalized cell therapy

Nature - A first-in-human phase I clinical trial demonstrates the feasibility and safety of non-viral precision genome-engineering of a personalized adoptive cell transfer anticancer...

nature.com
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CRISPR Platform retweeted
Eric Topol
@EricTopol10 Nov 2022
Just published @Nature 1st #CRISPR genome editing of immune T-cells to treat cancer, individualized for 16 patients with solid tumors, with some success nature.com/articles/s41586-0… nature.com/articles/d41586-0… by @heidiledford
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RADARS is a new RNA-sensing system developed by @omarabudayyeh, @jgooten + Fei Chen @broadinstitute that allows scientists to detect and target specific cell types and states, opening up potential applications in diagnostics and therapeutics. 🧬 mcgovern.mit.edu/2022/10/27/…

RNA-sensing system controls protein expression in cells based on specific cell states - MIT...

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have developed a system that can detect a particular RNA sequence in live cells and produce...

mcgovern.mit.edu
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Phase 1 clinical trial of #CRISPR -engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia Creating a universal cell therapy using CRISPR-mediated disruption of T cell receptor α chain and remove CD52 in CAR19 T cells science.org/doi/10.1126/scit…

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with...

CRISPR engineering allows for the creation of a universal CAR-T cell therapy for pediatric B-ALL.

science.org
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A new frontier in #CRISPR technology #Craspase cleaves protein (whereas Cas9 cuts DNA and Cas13 RNA) and it can be switched off. Adding a new option to the CRISPR toolkit and providing a new potential therapeutic platform. go.nature.com/3f97Tnl
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CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery #CRISPR nature.com/articles/s41564-0…

CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery

Nature Microbiology - A CRISPR-based oligo recombineering (CORe) approach functionally prioritizes electrophile-sensitive cysteines in Toxoplasma gondii and promotes anti-parasitic drug discovery.

nature.com
The end of PCR machines? Engineered helicase replaces thermocycler in DNA amplification while retaining desired PCR characteristics doi.org/10.1038/s41467-022-3…
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Fine-tuning epigenome editors Therapeutic applications for epigenome editing are restoring gene expression in congenital diseases of genome imprinting and autosomal dominant diseases of haploinsufficiency. #CRISPR go.nature.com/3yXYjKF
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Enhanced Genome Editing Toolkit Focuses on Delivery and Precision #CRISPR genengnews.com/topics/genome…

Enhanced Genome Editing Toolkit Focuses on Delivery and Precision

Jason Potter, director of cell biology at Thermo Fisher Scientific, shares his perspective on biopharma’s ability to harness CRISPR’s evolving toolkit for precision editing applications. Potter sees...

genengnews.com
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World CRISPR Day 2022 #CRISPR worldcrisprday.com/
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A bold effort to cure #HIV - using #CRISPR @ExcisionBio is turning CRISPR against the virus by targeting two regions in the HIV genome important for viral replication. Cutting out chunks of the HIV genome disables the virus from reproducing. wired.com/story/a-bold-effor…

A Bold Effort to Cure HIV—Using Crispr

An experiment tests whether the gene-editing technology can stop the virus from replicating, which would ultimately wipe out the infection.

wired.com
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CRISPR Platform retweeted
Josh Tycko@JoshTycko10 Oct 2022
Our paper is out! New recombinases for large DNA integration in human cells nature.com/articles/s41587-0… We discovered thousands of recombinases and their DNA targets by searching in mobile genetic elements🧬🦠 Our experiments showed some are promising tools for genome engineering🖋️
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Precise DNA cleavage using CRISPR-SpRYgests SpRYgests can improve various DNA engineering applications that benefit from precise DNA breaks. #CRISPR #geneediting nature.com/articles/s41587-0…
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Programmable RNA sensing for cell monitoring and manipulation CellREADR is a programmable RNA-sensing technology that leverages #RNAediting mediated by ADAR to couple the detection of cell-defining RNAs with the translation of effector proteins. nature.com/articles/s41586-0…
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CRISPR Platform retweeted
Luca Pinello@lucapinello4 Oct 2022
Do you want to learn where the gene editing field is heading? Please join us for this online event! Outstanding speakers lineup, *FREE* registration and several AWARDS for abstract submission: deadline *October 8th* Please retweet! #CRISPR hsph.harvard.edu/pqg-confere…
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A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection science.org/doi/10.1126/scit…
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