@ChulanKwonLab

Developmental and stem cell cardiology lab at Johns Hopkins studying cardiac maturation and heart organoids.

 Baltimore, MD
ck-laboratory.org/
Joined April 2019
  • Tweets81
  • Following160
  • Followers350
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We are moving to Bluesky due to Elon Musk's DOGE cutting science and research funding, his support of Trump, and much more. Follow us here! bsky.app/profile/chulankwonl…
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Our protocol paper on how to use entropy to quantify maturation status pmc.ncbi.nlm.nih.gov/article…

Protocol for quantifying stem-cell-derived cardiomyocyte maturity using transcriptomic entropy score

The inability to quantify cardiomyocyte (CM) maturation remains a significant barrier to evaluating the effects of ongoing efforts to produce adult-like CMs from pluripotent stem cells (PSCs). Here,...

pmc.ncbi.nlm.nih.gov
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Misato presented her work at AHA. Great job! #AHA2023
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Chulan Kwon Lab retweeted
Slava Bobrov
@slava__bobrov31 May 2023
Your heart structure from the inside: #biology by SciePro
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We are thrilled that @sean_murphy50 has been awarded a postdoctoral fellowship and that @punited has been granted a commercialization award from @MD_Stem_Cell. Congrats!!!
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Why don't iPSC-myocytes fully mature in dish? Our high-depth/resolution analysis reveals a transcriptomic halt during the perinatal stage, with dysregulated gene networks to blame. Need to repair the mired transcriptome! Led by @TheSurajKannan cell.com/cell-reports/fullte…

Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent...

By directly comparing single-cell RNA sequencing trajectories of in vivo and in vitro cardiomyocyte maturation, Kannan et al. find that pluripotent stem cell-derived cardiomyocytes fail to undergo a...

cell.com
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BTW, this is @TheSurajKannanj's thesis work, which took 5 yrs to complete. Excellent work and happy birthday!!!
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We are super proud of @mkmiyamoto for receiving the Sarnoff Fellowship and @TheSurajKannan for winning the Nupur Dinesh Tehkdi Award for outstanding research!!! You guys rock!!!
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We went night skiing and had no injuries!
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We had a great time at an escape room and Korean BBQ
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Chulan Kwon Lab retweeted
Benoit Bruneau@benoitbruneau2 Feb 2023
well good morning all! Martin Dominguez's and colleagues' paper is out today! cell.com/cell/fulltext/S0092…
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15+ years have passed since the discovery of Wnt signaling as a key regulator of SHF progenitors, but without knowing its source. Our study shows cardiac progenitors themselves secrete Wnts to govern this process. pnas.org/doi/10.1073/pnas.22…

Cardiac progenitors instruct second heart field fate through Wnts | PNAS

The heart develops in a synchronized sequence of proliferation and differentiation of cardiac progenitor cells (CPCs) from two anatomically distinc...

pnas.org
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Fantastic job, @mkmiyamoto, Hideki, and the team!!!
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Our lab's white elephant exchange from a few weeks ago. The most stolen gift was a dog puzzle!
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Lab members @Miller_CN_221 and @KwakuKQuansah recently finished the Baltimore Half Marathon and the Bay Bridge Run!
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Excited to preview a landmark study from the Keller lab defining the precursors and lineage markers of FHF, aSHF, pSHF from hPSCs! It’s a huge step towards understanding the origins of the human heart! Great job @mkmiyamoto! nam02.safelinks.protection.o…
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Here is the paper from the Keller Lab! cell.com/cell-stem-cell/full…

Modeling human multi-lineage heart field development with pluripotent stem cells

We describe hPSC-derived models of FHF, aSHF, and pSHF development spanning the mesoderm, progenitor, and cardiomyocyte stages. Comparison between the hPSC-derived and the corresponding mouse...

cell.com
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Our latest work looking at maturation across organs is out now in J. Comp Bio! Great job Sandeep, Hideki, and @sean_murphy50. doi.org/10.1089/cmb.2021.034…

Cross-Organ Transcriptomic Comparison Reveals Universal Factors During Maturation - Sandeep...

Various cell types can be derived from stem cells. However, these cells are immature and do not match their adult counterparts in functional capabilities, limit...

journals.sagepub.com
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Conférences et discussions fantastiques au Palais du Pharo ! Excellent travail, Biyi, @sean_murphy50, @ETampakak !
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The Department of EHE in the Johns Hopkins Bloomberg School of Public Health is continuing to accept applications at all ranks for a tenure-track position in reproductive or developmental toxicology. Cardiac developmental biologists are welcome to apply! apply.interfolio.com/102405
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