@benoitbruneau
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Cardiovascular disease researcher, developmental biologist, and Oakland resident. Je cherche a comprendre.
San Francisco Bay area
Joined April 2010
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Two flights in 8 hours cancelled by Air Canada for mechanical reasons. No more confidence in @AirCanada and yet I don’t have a fucking choice if I want to go to Montreal or Toronto bc @united is too lazy to go there. Missing time with my mother that I can’t get back
Benoit Bruneau retweeted
Don't miss out on this year's Weinstein Conference on Cardiovascular Development & Regeneration, in New York, May 6-8!
weinstein-conference.com/
Apply for a travel award ($500-1,000) by April 10th by filling out the following form:
forms.gle/kpvL3oR3sQFc5NMR9
Benoit Bruneau retweeted
Excited to share MaxToki, a temporal AI model that predicts the impact of perturbations on cell states over time along dynamic trajectories. We applied MaxToki to predict how cells age across the human lifespan & discovered new cardiac pro-aging drivers that we validated in vivo.
Hi @united UA1844 1/31/2026 does not have screen power and the rear restrooms (it’s a 757) are non-functional (only one now for the entire economy set). We’ve paid a lot including those of us in business. I’m returning from a family tragedy and was hoping for better.
“This is a court of law, not a court of morals,” he said”
Oh what a terribly missed opportunity here!
Breaking News: An Australian jury found a woman guilty of murdering three people by serving them toxic mushrooms, ending a trial that had captivated the nation. nyti.ms/44xVq27
Benoit Bruneau retweeted
How does heart failure rewire gene regulation? 🔍 Excited to share our single-cell, multimodal epigenomic resource on human heart failure🫀: doi.org/10.1101/2025.05.08.2….
Benoit Bruneau retweeted
Grateful & humbled to make the 2025 #TIME100HEALTH list with such inspiring global health leaders.
This honor reflects my team, who are unrelenting in their efforts to advance new treatments for pancreatic cancer!
TIME's new cover: Meet this year's #TIME100Health, a community of leaders—scientists, doctors, advocates, educators, and policy-makers, among others—who are changing the health of the world. ti.me/43802LZ
for #heart month, a nice piece on what we at @GladstoneInst are doing to understand heart disease better. Featuring @m_alexanian @TheodorisLab and Katie Pollard. for heart month, a nice little piece on what we do at Gladstone for the heart gladstone.org/news/matters-h…
The latest from @GladstoneInst of Cardiovascular Research and @ucsf: Isha Jain's lab, with an outstanding discovery of a small molecule that mimics hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, RA in Isha's lab, is first author! cell.com/cell/fulltext/S0092…
reupping this request to support my daughter's fundraising efforts for the @americanheart It's a worthy cause, and she is learning a lot from it. Thank you for considering. www2.heart.org/site/TR?px=28…
Hey there! Please consider supporting my daughter Nika as she raises funds for the American Heart Association as a 2025 Teen of Impact nominee. More than ever we need support for cardiovascular research, and this is a noble way to help. Thank you! www2.heart.org/site/TR?px=28…
Benoit Bruneau retweeted
Ten years.
Together we built a warm, tight-knit, international community, shared new computational and experimental technologies around the the world, posted >400 preprints, and catalyzed understanding of the mechanisms and functions of chromatin in development and disease.
Benoit Bruneau retweeted
Check out this wonderful Perspective piece in @ScienceMagazine by Christina Theodoris @UCSF @GladstoneInst: science.org/doi/10.1126/scie…
Benoit Bruneau retweeted
Happy to share our new work describing DESynR genes!
The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable high-throughput generation and screening of base-pair level sequence evolution (mutagenesis, directed evolution, CRISPR, etc), we lack similar scalable technologies for domain-level evolution.
We developed a high-throughput combinatorial molecular assembly method to generate thousands of barcoded novel genes from the domain building blocks of natural genes, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.
A little noise making @wbderry @TheLovelyLab @chrmosimann
Benoit Bruneau retweeted
The 3rd edition of this comprehensive review on the genetics and biology of #PancreaticCancer is now published in @GenesDev
genesdev.cshlp.org/content/e…
Updated information with several useful illustrations and citations. Thanks @RonDePinho @HaoqiangY @rkalluriMDPhD Alec Kimmelman, Nabeel Bardeesy.
Enjoy!
