Our small green planet
Joined February 2018
- Tweets27
- Following46
- Followers102
- Likes31
Dmitriy M Chudakov retweeted
1/7 We are pleased to report the 2026 VDJdb release, just published in Nucleic Acids Research: 203,230 TCR:pMHC records over 2,090 epitopes and 236 MHC alleles, 37-fold the first release, 4-fold our 2022 COVID-19 compendium.
#immunology #bioinformatics
academic.oup.com/nar/advance…
T Cell Thoughts. Not a classic review: pubmed.ncbi.nlm.nih.gov/4271…
Dmitriy M Chudakov retweeted
N.B. VDJdb is up and running after a planned server upgrade, it can be now accessed at vdjdb.com, the old vdjdb.cdr3.net URL redirects there and should be considered obsolete. If you are using VDJdb web API please update accordingly.
Dmitriy M Chudakov retweeted
First manuscript from my group! 🐢🐢🐢🐢 @StJudeResearch
TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 biorxiv.org/content/10.1101/… (1/11)
Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen. Yes, it works: pubmed.ncbi.nlm.nih.gov/3898…
And one more manuscript from our team, also focussed on Treg. Purely repertoire-based as we like)) Beautiful (!) data from Prof. Rudensky. Long work, short read. pubmed.ncbi.nlm.nih.gov/3859…
Happy to report our development for scRNA-Seq analysis. Employs splicing information at the level of clustering and dimensionality reduction. Readily revealed beautiful aspects of Treg and Th1/CD4+ cytotoxic biology. Try! biorxiv.org/content/10.1101/…
Dmitriy M Chudakov retweeted
Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis nature.com/articles/s41591-0…
We started this work ~15 years ago. Now it is on the 2nd phase clinical trial. With all the circumstances, things evolve towards new generation immunotherapies, to make life happier on our small fragile planet.
Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis nature.com/articles/s41591-0…
Dmitriy M Chudakov retweeted
Spectacular finding from Dmitryi Chudakov group (time to get a Twitter handle!) @CEITEC_Brno. Blind moles are special, they #live #long and prosper, now we know, at least in part, why. It goes down to the organisation of their adaptive #immune #system. 👏
Izraelson et al. @CEITEC_Brno, @immunology_s reveal that the adaptive immune system of the long-lived blind mole rat is organized differently over its lifespan from other rodents. Read it here: nature.com/articles/s43587-0…
Great Misha's work
Our collaborative project (@pogorely, @elisarosix, @BensoudaMeriem, @an_franke, @ChudakovM and others) about longitudinal #TCR repertoire sequencing after #SARSCoV2 infection is now also on biorxiv. biorxiv.org/content/10.1101/…
nature.com/articles/s41590-0…
Admiration, envy, hope, inspiration ... altogether. And love for Andrew Sewell and his way of thinking. Ultimately - inspiration.
nature.com/articles/s41577-0…
Yet many things unclear, but was a great pleasure to dig.
SupplTable1 tries to summarize clinically relevant things, some controverisal. Great work by George Sharonov.
Intersting what people say on IgG1/IgG3 difference hypothesized on Fig. 3.
Dmitriy M Chudakov retweeted
TCGA RNA-Seq analysis reveals strong association between Tumor-infiltrating B-cell antibody isotypes and survival in lung adenocarcinoma carrying specific driver mutations.
jitc.biomedcentral.com/artic…
Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell level disq.us/t/3j7jxy4
Dmitriy M Chudakov retweeted
Our latest study on immune responses to the flu vaccine and B cell memory in human tissues is out today and featured on the cover of @ScienceTM!
@TheDohertyInst @UniMelbMDHS stm.sciencemag.org/content/1…
Dmitriy M Chudakov retweeted
CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients academic.oup.com/rheumatolog…
Dmitriy M Chudakov retweeted
New from Andrew Sewell lab: "Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations" jimmunol.org/content/early/2… @J_Immunol
