Professor of Internal Medicine and Biomedical Engineering @WUSTL; @WUSTLmed; @SitemanCenter; Studying #cancer #genomics #lncRNAs #bioinformatics
St Louis, MO
Joined July 2015
- Tweets153
- Following119
- Followers346
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Christopher Maher retweeted
Truly honored and grateful to be awarded the PCF Challenge Award with this incredible group of friends and collaborators + my super-⭐️ mentee @pradeep198212!
Quite the team! @AOSartor @ChrisMaher_Lab @RPachynski @JakeOrmeMDPhD @flscientist Elisa Ledet
Christopher Maher retweeted
Interested to read the ins and outs of our Fast & Fair peer review experiment? Read the preprint at bit.ly/424d9x3 #fastandfairpeerreview
If you are interested in a Fast (7 days) and Fair peer review process consider this new initiative @BiologyOpen.
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick at: bit.ly/4kYD1mL
ALT Fast & Fair peer review A new initiative offering high-quality peer review within 7 working days of submission Biology Open
Christopher Maher retweeted
In memory of Dr. Felix Feng. Thank you @EUplatinum for honoring our beloved colleague and friend, gone too soon. We miss you Felix @MaryFengMD @nlinmd @PCF_Science
sciencedirect.com/science/ar…
Christopher Maher retweeted
Cover 🤗…congrats to the whole team! 🎉 @aadel_chaudhuri @ChrisMaher_Lab @sartor_oliver @ChadTangMD @WashUOncology @SitemanCenter @WashUDeptMed @MayoClinic @MDAndersonNews @PCF_Science @Pachynski_Lab
Christopher Maher retweeted
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
Christopher Maher retweeted
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
Christopher Maher retweeted
Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer Out on @CCR_AACR
Study investigates metastatic castration-resistant #ProstateCancer (mCRPC) resistant to androgen receptor signaling inhibitors (ARSIs), a highly lethal form of @cancer . Using targeted and genome-wide cell-free DNA sequencing from 126 and 43 mCRPC patients, respectively, researchers found that AR/enhancer alterations in cell-free DNA🧬 prior to ARSI treatment correlated with significantly worse PFS and OS
Further analysis of the plasma methylome revealed increased promoter-level hypomethylation in patients with these alterations. Additionally, transcription factor analysis suggested that cancer lethality is driven by increased stemness. This stem-like signature was validated in a separate cohort, establishing AR/enhancer alterations as a prognostic biomarker for lethal mCRPC.
aacrjournals.org/clincancerr…
@pradeep198212
@RBabbra
@SydneyCaputo
@flscientist
@ChadTangMD
@RPachynski
@OJSartor
@ChrisMaher_Lab
@aadel_chaudhuri
@MayoRadOnc
@MayoCancerCare
@MayoClinic
@TulaneMedicine
@MDAndersonNews
@WashUOnc
Great collaborative effort!!! Awesome job @pradeep198212
Proud of @pradeep198212 (lead scientist) + PhD student Irfan +undergrad Savar for our latest ctDNA paper @CCR_AACR on met prostate cancer!
aacrjournals.org/clincancerr…
@MayoRadOnc @MayoCancerCare @MayoClinic @CaltechSFP @WashUOnc @TulaneMedicine @OJSartor @RPachynski @ChrisMaher_Lab
Christopher Maher retweeted
Portrait unveiling at the conclusion of the John F DiPersio Immunotherapy Symposium
@WashUOnc @SitemanCenter @WUDeptMedicine @WUSTLmed @BarnesJewish @WUSTLdbbs @WashUDPS
#bmtsm #celltherapy #cartcells #leusm #lymsm #mmsm #mdssm
Congrats Dr. Zhao!!!
I made it! Yesterday I defended my thesis in Computational & Systems Biology at Wash U! Thank you @ChrisMaher_Lab for a fun and challenging 6-year adventure!
Excited to share our collaborative work with @felixfengmd @David_A_Quigley using #scRNA-Seq to study the #lncRNA landscape in metastatic castration resistant #prostate #cancer
Read at npj Genomic Medicine
rdcu.be/dApls
@WashUOnc @SitemanCenter @PCF_Science @WUSTLmed
Christopher Maher retweeted
New in NAR Cancer. A resource to guide functional studies: a compendium of long noncoding RNAs associated with tumor, immune, or stromal cells in pancreatic cancer. From @ChrisMaher and coworkers. @WUSTL @SitemanCenter #lncrnas #bioinformatics. academic.oup.com/narcancer/a…
Great to see this collaborative work with @aadel_chaudhuri and @RPachynski online now!
On @medrxivpreprint!
“Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in AR-altered lethal prostate cancer”
medrxiv.org/content/10.1101/…
Kudos to @pradeep198212 & Irfan Alahi in my lab for leading the work!
Excited to share our collaborative work with Ryan Fields and Li Ding
Single-cell transcriptomics reveals long #noncoding #RNAs associated with tumor biology and the microenvironment in #pancreatic #cancer
academic.oup.com/narcancer/a…
@WashUOnc @SitemanCenter @WUSTLmed
Excited to be a "Featured Fighter"
youtube.com/watch?v=8Ii9MGW9…
@pedalthecause funding has been instrumental in accelerating our research!
@SitemanCenter @WashUOnc
Great work Scott!
Check out our latest work showing ecDNA as a way that prostate cancer cells can amplify and structurally diversify the AR gene in advanced prostate cancers! Great collaboration with @uwurology @felixfengmd @UCSFCancer @benjraphael @UMNCancer
academic.oup.com/narcancer/a…
A fun morning of #tennis with the lab at the Rally for Cancer Care. $25,000 raised for the Patient Care Fund to assist patients with financial distress due to a recent #cancer #diagnosis
@WashUOnc @SitemanCenter
After multiple positive experiences as an author, I'm excited to contribute as an Associate Editor of NAR Cancer! Would love to see more submissions related to #noncoding #RNAs, #compbio, and #bioinformatics
@NAR_Cancer_EIC @WashUOnc
academic.oup.com/narcancer
