Chemical biology, CRISPR and beta-cell biology @ Broad Institute | Harvard Medical School | Brigham and Women's Hospital
Cambridge, MA
Joined November 2018
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The Amit Choudhary Lab retweeted
Sign to endorse: forms.gle/kDijWXMKdSpkvcFG6
The Amit Choudhary Lab retweeted
Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get @Nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? @GoogleDeepMind
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
The Amit Choudhary Lab retweeted
Thankful for this recognition. All credits go to my group's past and present members; I have been truly fortunate to work with them!
Congratulations to the winner of the 2024 Bioconjugate Chemistry Young Investigator Award, Professor Abhishek Chatterjeee, Boston College. #chemistry #award @BostonCollege @AChemSynBio @ACSPublications
tinyurl.com/my3a3jxk
The Amit Choudhary Lab retweeted
We got a story, and it’s electric! 🔌⚡️ rdcu.be/dth70
Can electrocatalysis be used to precisely modify a protein? Yes! Happy to finally share this work led by @conor_loynd and @SinghaSoumya. A 🧵 #ProteinElectrochemistry #NSFfunded
The Amit Choudhary Lab retweeted
Congratulations to @CraigMCrews on receiving the Kimberly Prize from @NUFeinbergMed for pioneering studies of #PROTACs in the lab and their translation to clinical trials! Read more here: news.feinberg.northwestern.e…
The Amit Choudhary Lab retweeted
The first in vivo base editing clinical trial outcomes are now reported, following last year’s positive ex vivo base editing clinical outcomes!
Congratulations to @kiranmusunuru , @skathire, @ambellinger, @NicoleGaudelli, & other scientists at @VerveTx and @BeamTx on these positive data.
The culmination of 10+ years of work to use #CRISPR gene editing to fight heart disease!
@ambellinger @VerveTx $VERV presenting the interim data from the ongoing heart-1 Phase 1b clinical trial of VERVE-101 base editing for HeFH patients, at #AHA23 now.
Let’s start!
🧵
The Amit Choudhary Lab retweeted
New @biorxivpreprint from our lab by @Qian37774492 on a covalent 14-3-3 molecular glue with the transcription factors YAP and TAZ and using this glue as a 14-3-3 recruiter to sequester nuclear neo-substrates into the cytosol! Thanks to #AppleTreePartners & @themarkfdn
biorxiv.org/content/10.1101/…
The Amit Choudhary Lab retweeted
Happy to share our most recent contribution coupling covalency with carbohydrate binding for immune proximity induction.
pubs.acs.org/doi/full/10.102…
The Amit Choudhary Lab retweeted
I worry that this organization will put more pressure on reviewers to focus on the details and put even less focus on creativity and impact. That already seems to be an issue that was not addressed with these changes.
Anyone who writes or reviews NIH grants will want to read this:
nexus.od.nih.gov/all/2023/10…
In @ACSCentSci, we report two chimeric molecule platforms to induce tyrosine phosphorylation, a critical PTM. Chimeras (formed by fusing target and kinase binders) force kinase to phosphorylate non-substrate via induced proximity
tinyurl.com/3kt8svjb
Group transfer/proximity-induced labeling chemistries are well known (see Westheimer et al, Hamachi et al). Wyeth (2001) and AstraZeneca (2013) reported thiol-based group transfer for EGFR inhibitors, Thai et al (2020) have called it TMAcs and London et al (2021) CoLDR. Soon...
The Amit Choudhary Lab retweeted
What if small molecules could allow you to alter protein localization at will?
What if they could allow you to turn on specific transcription factors?
Our new manuscript reveals bifunctional molecules to do just that. 🧵
The Amit Choudhary Lab retweeted
Excited to see our @ACSCentSci paper published on rational design of molecular glue degraders via a transplantable covalent handle! Congrats to @EthanToriki, @JPapatzimas, @NovartisScience, and team! Thanks also to @TheMarkFdn! @UCB_Chemistry pubs.acs.org/doi/10.1021/acs…
The Amit Choudhary Lab retweeted
Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X sciencedirect.com/science/ar…
The Amit Choudhary Lab retweeted
Very disappointed to see this new paper in @NatureCancer on a clinical trial with “HDAC6 inhibitor” ricolinostat. The paper fails to mention three recent reports demonstrating that this drug exhibits pervasive off-target toxicity.
The Amit Choudhary Lab retweeted
The great @LynJonesChemBio and I partnered with an exceptional group of experts to bring you a book that talks about how thinking about protein homeostasis more holistically could help us find future medicines!
A gratitude 🧵
