@LynJonesChemBio

Dana-Farber Cancer Institute

 Massachusetts, USA
scholar.google.com/citations?hl=en&user=44KLF4sAAAAJ&view_op=list_works&authuser=1&sortby=pu
Joined November 2018
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New bioRxiv preprint: covalent remodeling of CRBN locks His353 in a conformation that avoids the IMiD clash and polarizes the C2–H to form a new edge‑to‑face interaction with NTAQ1 Phe126. #TargetedProteinDegradation #MolecularGlue biorxiv.org/content/10.64898…

Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1

Molecular glue degrader EM12-FS covalently modifies cereblon (CRBN) His353, enabling selective recruitment of the neosubstrate NTAQ1 to the CRL4CRBN ubiquitin ligase. We determined the cryo-EM...

biorxiv.org
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A week late, but I was able to complete my Jimmy Fund Walk today - thank you to everyone who supported me! #JimmyFundWalk
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I’m taking steps to defy cancer at the Jimmy Fund Walk. Every donation to my walk will make an impact on the lives of patients and families at Dana-Farber. #JimmyFundWalk danafarber.jimmyfund.org/sit…

Jimmy Fund Walk for Dana-Farber

Make an impact on Dana-Farber's mission to defy cancer

danafarber.jimmyfund.org
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Chemistry rewires biology: subtle changes to glutarimide analogs reshape degron selectivity, reprogramming CRBN toward new ZF targets.
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Want to be at the forefront of next-generation covalent chemical biology? Open postdoctoral fellow positions in my lab: careers.dana-farber.org/job/… careers.dana-farber.org/job/…
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Advances are being made to rationally design and develop cereblon-based molecular glue degraders - here's a perspective on their property-based optimization pubs.acs.org/doi/full/10.102…

Property-Based Optimization of Cereblon-Based Molecular Glue Degraders

Abstract. Molecular glue degraders that bind the E3 ligase adaptor cereblon are clinically precedented drugs used to treat cancer. Highly potent next-gener

pubs.acs.org
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🎉 2025 DFCI TPD event registration is open! 📆 Sep 11, 11:30 AM–8 PM ET, Boston 🔑 Keynote: Nathanael Gray 📝 Registration link: forms.gle/NLUSa51Btrtf6FsQA #TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
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We are delighted to announce that our 2024 Emerging Investigators collection is now online👀 This themed collection aims to highlight the achievements of some early career researchers in the medicinal chemistry community. Access it here👉 pubs.rsc.org/en/journals/art…
RSC Medicinal Chemistry promotional graphic for the 2024 Emerging Investigators collection.

ALT RSC Medicinal Chemistry promotional graphic for the 2024 Emerging Investigators collection.

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📢We are delighted to announce that @MichaelBollong (@scrippsresearch) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship🎉 Join us in congratulating Michael and read our blog to find out more about him and his work: blogs.rsc.org/md/2025/01/30/…
RSC Medicinal Chemistry promotional graphic for the 2025 Emerging Investigator Lectureship winner - Michael Bollong.

ALT RSC Medicinal Chemistry promotional graphic for the 2025 Emerging Investigator Lectureship winner - Michael Bollong.

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'Linkerless' PROTACs? Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α - now published in @rsc_medchem pubs.rsc.org/en/content/arti… #PROTAC #TPD

Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α†

IRE1α is an ER protein involved in the unfolded protein response (UPR) and dysregulation of the ER stress pathway has been implicated in several diseases.

pubs.rsc.org
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🔓Take a look at recent #OpenAccess research by Xiaoyu Zhang (@xzhang85) and colleagues on exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development🔥 pubs.rsc.org/en/content/arti… 📍@NorthwesternU

Exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development†

Traditional small molecule drugs often target protein activity directly, but challenges arise when proteins lack suitable functional sites. An alternative

pubs.rsc.org
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Also in this month's issue is an update on Target 2035 from @CherylArrowsmi1, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035💡 Read the #OpenAccess article here⬇ pubs.rsc.org/en/content/arti…
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Curious about #RSCPoster? Our latest video explains everything you need to know about this exciting competition! Discover how you can showcase your research, gain recognition, & connect with fellow scientists. Watch the video and get inspired - Register rsc.li/3BtGKH7
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Exploration of degrons and their ability to mediate targeted protein degradation - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/arti…

Exploration of degrons and their ability to mediate targeted protein degradation

Degrons are short amino acid sequences that can facilitate the degradation of protein substrates. They can be classified as either ubiquitin-dependent or -

pubs.rsc.org
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We’re excited to share the story of the discovery and early clinical development of JNT-517, our oral small molecule drug candidate being evaluated in PKU, in the peer-reviewed journal @JCI_insight. Access it here: bit.ly/4g5Qpm7
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Great event - registration open now!
Royal Society of Chemistry
@RoySocChem2 Dec 2024
🔔 Mark your calendars! The 10th anniversary of the #RSCPoster competition on LinkedIn is approaching between 12 midday 4 March to 12 midday (UK time) 5 March 2025. Get ready to showcase your research! #SaveTheDate #RSCPoster2025
Promotional image for the Royal Society of Chemistry's 24-hour online conference on LinkedIn, celebrating their 10th anniversary. Includes event details: Join on 4 March 2025 at 12:00 UK time, with a reminder to save the date. The background features a network of connecting lines and dots.

ALT Promotional image for the Royal Society of Chemistry's 24-hour online conference on LinkedIn, celebrating their 10th anniversary. Includes event details: Join on 4 March 2025 at 12:00 UK time, with a reminder to save the date. The background features a network of connecting lines and dots.

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As a heads up I'm being impersonated on X - please ignore any posts and direct messages from them.
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Characterization of a Novel Macrocyclic Molecular Glue That ... : Journal of the American Society of Nephrology journals.lww.com/jasn/abstra…
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We're excited to share our most recent publication in the journal ACS Chemical Biology on a novel corrector for variants of SLC6A8 as a potential treatment approach for creatine transporter deficiency (#CTD). bit.ly/3YXaPrv @ACSPublications #raredisease #genetics
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🌟Inspired by yesterday's @NobelPrize news? Want to read more about the use of AI in chemistry❓ Check out our latest themed collection on AI in medicinal chemistry guest edited by Jian Zhang , Ola Engkvist and Gerhard Hessler👇 pubs.rsc.org/en/journals/art…
RSC Medicinal Chemistry promotional graphic for AI in Medicinal Chemistry themed collection.

ALT RSC Medicinal Chemistry promotional graphic for AI in Medicinal Chemistry themed collection.

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