@ChemBioNAC

Chemical Biology and Nucleic Acid Chemistry Group at #IBMM @umontpellier @chimiebalard Group leader @Smietana_M

 Montpellier, France
chembionac.com
Joined December 2018
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  • Following287
  • Followers548
36Media
Excited to share our new paper in Nature Communications in collaboration with @OBasle ! We report the first artificial metallo-photoDNAzyme enabling highly enantioselective visible-light photochemistry via a DNA-embedded iridium photocatalyst. nature.com/articles/s41467-0…
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ChemBioNAC retweeted
ChemistryEur@ChemistryEurFeb 23
Proximity-Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge-Transfer Interactions by Francois Morvan, Michael Smietana, and co-workers (@Smietana_M) #OpenAccess chemistry-europe.onlinelibra…

Proximity‐Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge‐Transfer...

Charge-transfer assisted ligation (CTAL) enables ultrafast CuAAC and SPAAC conjugation of a tetra-DiAlkoxyNaphthalene (DAN4)-azide and a noncomplementary tetraNaphthaleneDiImide (NDI4)-alkyne...

chemistry-europe.onlinelibrary.wiley.com
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When the Position of Pendant Groups Makes the Difference in G-Quadruplex Behavior: The Case of Bis-Conjugated Thrombin-Binding Aptamers #Aptamers pubs.acs.org/doi/10.1021/acs… @Smietana_M @ChemBioNAC @orozco_lab @DanielaMontesa9 @umontpellier @IRBBarcelona #JCIM Vol66 Issue1 #compchem

When the Position of Pendant Groups Makes the Difference in G‑Quadruplex Behavior: The Case of...

Abstract. In the search for effective and low-toxicity anticoagulant agents, the G-quadruplex-forming thrombin-binding aptamer (TBA) with sequence 5′-GGTTG

pubs.acs.org
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📢DNA templates are no longer required for efficient nucleic acid ligation. 💡We introduce Charge-Transfer Assisted Ligation (CTAL): a new templated reactivity based on π-stacking donor–acceptor interactions (DAN/NDI), not base pairing. 📄 Open access: chemistry-europe.onlinelibra…
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Replying to @ChemBioNAC @CNRSchimie
Merci à @CNRSchimie, @umontpellier de m’avoir offert un super environnement pour exercer 40 ans de recherche dont 36 exercées au @CNRS qui ont abouti à une carrière dont je suis fière. Un grand merci à mes étudiants, ingénieurs qui ont largement contribué à ma réussite.
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Replying to @ChemBioNAC @CNRSchimie
Mes sincères remerciements vont à l’équipe @ChembioNAC pour avoir organisé mon pot de départ entre collègues et amis. Une nouvelle page se tourne pour moi vers des activités différentes mais le flambeau des ARN modifiés et coiffés est entre de bonnes mains pour durer et réussir🤞
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We were delighted to celebrate the retirement of @DebartFrancoise, closing a remarkable chapter and opening a new one. It was a warm and heartfelt moment, reflecting her dedication and the positive impact she has had on all of us over the years. Thank you Françoise! @CNRSchimie
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Had a great day visiting @DebartFrancoise and Michael Smietana at IBMM in Montpellier. 😊 Thank you for the invitation, the hospitality and the scientific discussions. 🧬🤩
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Our lastest article has just been released (Org. Biomol. Chem): Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages pubs.rsc.org/en/content/arti… @CNRSchimie @umontpellier @enscmchimiemtp @ChemBioNAC @IBMM_Balard

Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing...

We report the synthesis of (2-(N-acetylsulfamoyl)ethyl)carbamate (NAC)-linked thymidine dinucleotide via the sulfo-click reaction and its incorporation int

pubs.rsc.org
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ChemBioNAC retweeted
EuroBoron10@eu10boron5 Jun 2025
🎇Please meet our next 10th Euroboron invited speaker - Michael Smietana🎇 Michael is Professor at the University of Montpellier, France. His current research focuses on molecular recognition and nucleic acid bioconjugates, in particular boron-modified nucleic acids.
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Very pleased to share our latest publication on the Synthesis and Base-Pairing Properties of Oligonucleotides Containing 5′-(R)- and 5′-(S)-C-Aryl-thymidine now in JOC pubs.acs.org/doi/10.1021/acs… @DebartFrancoise @VasseurJeanJacq @HausdorffMarcel @CNRSchimie @umontpellier @ChemBioNAC
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We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)! Published in @ChemicalScience Led by @disha_kashyap_, with @milnetom68 pubs.rsc.org/en/content/arti…

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking†

Antisense oligonucleotides (ASOs) can modulate gene expression at the mRNA level, providing the ability to tackle conventionally undruggable targets and us

pubs.rsc.org
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Kudos to @PastorelZachary and Juliette Zanzi Great Team work with @OBasle @CanacYves @arseniyadis @elisejdumont and Alessio Bartocci @CNRS @umontpellier @IBMM_Balard @ChemBioNAC @LCC_CNRS @NiceChemistry
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🚨 Looking for a stimulating environment where your expertise in chemical biology can shine ? The Institute IBMM invites applications for 2 CNRS tenure-track positions. -> Glycochemistry -> RNA Chemistry contact : [email protected] To apply : carrieres.cnrs.fr/recrutemen…
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Very happy to share out new pre-print on the enzymatic GalNAc-labelling of oligonucleotides. Big congrats to undergraduate student Elisa and graduate student @pierrenicolas_b ! chemrxiv.org/engage/chemrxiv… @institutpasteur @CNRSchimie

Towards the enzymatic labelling of oligonucleotides with triantennary N-acetyl galactosamine |...

The inclusion of chemical modifications into oligonucleotides stabilizes their backbones against nuclease mediated degradation and improves their biological activity. Even though cellular, tissue,...

chemrxiv.org
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🚨 Looking for a stimulating environment where your expertise in chemical biology can shine ? The Institute IBMM Balard invites applications for two CNRS tenure-track positions. -> Glycochemistry -> RNA Chemistry Contact : [email protected]
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Very special scientific day on the occasion of @VasseurJeanJacq retirement. Thanks to the speakers for their great lectures and thanks to all the participants. Happy retirement Jean-Jacques !🌴☀️🚴 @umontpellier @ChemBioNAC @IBMM_Balard @Philippe_Auge @PascalDumy
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Fantastic lectures on photo-biocatalysis, transition-metal catalysis and organocatalysis at @UNamur chemistry department. Great dissussions with @GrimaudLaurence (ENS Paris), @Smietana_M (Univ Montpellier @ChemBioNAC), E McGarrigle (@McGarrigleGroup, UCDublin) and @OlivierRiant.
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Mini-symposium this Friday at the chemistry department of @UNamur. Three invited speakers: Prof. Smietana (@Smietana_M), Grimaud (@GrimaudLaurence) and McGarrigle (@McGarrigleGroup). Looking forward to welcome you and talk about chemistry!
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#EurJOC Recent Development of DNA-based Biohybrid Systems Driven by Light (Michael Smietana and co-workers) @Smietana_M @OBasle @Chembionac • onlinelibrary.wiley.com/doi/…

Recent Development of DNA‐based Biohybrid Systems Driven by Light

Merging the fields of photochemistry and DNA-based materials paved the way for unprecedented reactivities and applications. This review focuses on recent developments around the design of biohybrid...

chemistry-europe.onlinelibrary.wiley.com
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