@Chapman_Lab

The Chapman Lab at the University of Michigan studies bacterial biofilms and the biology of functional amyloids. Account managed by trainees

 Ann Arbor, MI
sites.lsa.umich.edu/chapman-lab/
Joined May 2016
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Our most recent publication on anti-amyloid chaperone protein CsgC is out now! Special thanks to Sarabella for the JBC cover design which perfectly captures this work. Check it out here: jbc.org/article/S0021-9258(2…

The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsi...

Escherichia coli assembles a functional amyloid called curli during biofilm formation. The major curlin subunit is the CsgA protein, which adopts a beta-sheet-rich fold upon fibrillization. The...

jbc.org
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I'm so fortunate to have great mentors who are superb human beings. Thanks to @mattchapman22 for a wonderful evening. It was great to catch up with @Chapman_Lab. Thanks to @caglatukel for this opportunity!!
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Cell Surface-localized CsgF Condensate is a Gatekeeper in Bacterial Curli Subunit Secretion biorxiv.org/cgi/content/shor… #bioRxiv
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I’m happy to announce that I successfully defended my Dissertation on Monday. Thank you to everyone who joined us at the defense, we had a packed house! And of course, thank you to everyone in the @Chapman_Lab for helping me finish this life goal. On to my next challenge!
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I'm happy to announce that I've been awarded a Rackham Predoctoral Fellowship! Thank you to @umichgradschool! Also, big thanks to the members of @Chapman_Lab and @UMChemBio who have helped me get this far in my graduate studies. #UMChembio chembio.umich.edu/anthony-ba…
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The second publication this year for our graduate student @Abalist_chembio! He and Emily were able to put together a great review arguing for the importance of functional amyloids in cellular biology. Give it a read and let us know what you think! mdpi.com/918144
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Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae. @PLOSBiology
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@StallingsLab @HultgrenLab @Chapman_Lab @PeONor @KimInSingapore @BacterialTalk @BackvallJEB_grp @BergstromSven @GlobischLab @LwkMoodie @UAC_UU @Ucmr_sweden
Fredrik Almqvist@FredrikAlmqvis112 Jun 2020
I am excited to announce that there are three postdoc opportunities open for applicants to join my lab at Umeå University! Inspiring projects including collaborations with amazing scientists around the globe :) nature.com/naturecareers/job… nature.com/naturecareers/job…
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First manuscript to leave the "Ant Farm", led by graduate student Anthony (Antz) @Abalist_chembio and highschool students Soorya and Ethan (now college bound). All of our papers are awesome, but we're particularly proud of this work frontiersin.org/articles/10.…

Frontiers | Tuning Functional Amyloid Formation Through Disulfide Engineering

Many organisms produce ‘functional’ amyloid fibers, which are stable protein polymers that serve many roles in cellular biology. E. coli and other Enterobact...

frontiersin.org
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The news cycle with Covid-19 is confusing largely because it showcases how messy research is.
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What we learn from this is to not be too attached to any one answer early on that paints us into a corner. More information makes our answers better. It is on us all to think critically about new information and to ask the right questions.
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#Covid_19 #StrongerTogether #research
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Overtaken by stress granules. Still pulling for you @CellfOrganized #carboxysomes
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Representing for our neighbor lab, @CellfOrganized
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It's an honor to be part of STC Talmudic questions alongside other powerhouses of the amyloid field!
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Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies Klein and Hultgren discuss how novel insights may guide the development of antibiotic-sparing therapeutics @HultgrenLab @Roger__Klein nature.com/articles/s41579-0…
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So proud of this paper and all the hard work that went into this story. Bacterial curli fibers produced in the gut can accelerate alpha-syn aggregation in the brains of mice @Jain_Lab elifesciences.org/articles/5…

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.

elifesciences.org
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Surprisingly on time! Wow! First time for everything at the #chapmanlabsymposium
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