Viral Immunology researcher in the Division of Infection and Immunity at Cardiff University. Views my own.
Cardiff, UK
Joined June 2014
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Dr. Ceri Fielding retweeted
Dr. Leo James and team propose in @MolecularCell that TRIM21 evolved through competition with pathogens to induce #autophagy of diverse and complex substrates, potentially explaining its versatility for targeted protein degradation.
bit.ly/4xxVcps
Dr. Ceri Fielding retweeted
Rapid Affinity Characterization of Cell-Free Expressed Nanobodies Directly in Lysate with Biolayer Interferometry via Antigen-Immobilized Biosensors
pubs.acs.org/doi/10.1021/acs…
Dr. Ceri Fielding retweeted
Infection of rhesus macaques with a chimeric virus uncovers a recipe for broadly neutralizing anti-HIV antibodies @ScienceMagazine
science.org/doi/10.1126/scie…
science.org/doi/10.1126/scie…
Dr. Ceri Fielding retweeted
Cancer-associated fibroblast subtypes differentially modulate NK cells in cancer @CellReports
cell.com/cell-reports/fullte…
Dr. Ceri Fielding retweeted
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
Maybe one of the most important IBD papers - 3-5% of CD disease caused by IL10 autoantibodies... B-cell therapies???
Dr. Ceri Fielding retweeted
A whole genome sequencing assay named HPV-DeepSeek sniffs out signs of residual disease after surgery in patients with #HPV+ head and neck cancer, and detects recurrence earlier than digital PCR and standard clinical criteria. @FadenLab @BIDharvardOHNS scim.ag/3S52VLF
Dr. Ceri Fielding retweeted
A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB
Dr. Ceri Fielding retweeted
In the last year, we’ve:
✅Developed a next-generation in vivo CAR-T platform of high specificity & efficacy
✅Entered the second half of recruitment in our first in-human clinical trial, CARxALL
✅Built and strengthened collaborations with research institutions & global partners
Dr. Ceri Fielding retweeted
Wow just heard about new clinical trials of a new drug for hep B infection at the European HIV hepatitis meeting - antisense oligo nucleotides showing promising results in those already taking nucleotide/side inhibitors. And for hep D a new entry inhibitor.@hkjcghi @MedCambridge
Dr. Ceri Fielding retweeted
1/ Congratulations to our UK colleagues on this landmark @NEJM study: “Interleukin 10 Autoantibodies and HLA DRB1*01:03 in IBD”nejm.org/doi/full/10.1056/NE…
A powerful example of how discoveries from rare monogenic #VEOIBD can illuminate mechanisms relevant to common #IBD.
Dr. Ceri Fielding retweeted
I am super proud to post a BEAUTIFUL review in Nature Reviews Microbiology that started as Dinh's PhD thesis introduction, and matured over a two year period, into a view on how he studies RNA virus evolution and how those concepts can be used in applied virology. Dinh Tran joined my group as a PhD student coming from a background of solid evolutionary sciences and population genetics, and trying to transform his wisdom to us and how we develop antiviral approaches. He is now a postdoctoral fellow, applying all these concepts to his own research program.
This is a very useful review, I hope you enjoy it. It is written for a broad audience, for students and scientists in the field and in related fields.
rdcu.be/fiHde
Share it with everyone!
Dr. Ceri Fielding retweeted
Today my laboratory is thrilled to announce a major breakthrough in the fight against the common cold and other diseases like hand,foot, and mouth disease acute flaccid myelitis caused by picornaviruses. We present the first structure of picornaviral 2C, bound to ssRNA (1/n)
Dr. Ceri Fielding retweeted
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. doi.org/10.64898/2026.06.03.…
Dr. Ceri Fielding retweeted
Lipid droplets are key immunometabolic platforms in early antiviral defence @NatureComms @ebony_monson @TimetogoZ @Latrobe @JayLaws15
@HelbigLab
nature.com/articles/s41467-0…
Dr. Ceri Fielding retweeted
📝 A new @MolecularCell study led by Dr. Leo James demonstrate that TRIM21 rapidly intercepts antibody-pathogen complexes, leading to ubiquitin ligase activation. bit.ly/4odCa3J
They propose that TRIM21 evolved through competition with pathogens to induce autophagy of diverse and complex substrates. 🦠
#OpenAccess
Dr. Ceri Fielding retweeted
Can AI predict which flu strains will jump to humans? New preprint uses protein language models to forecast influenza host tropism & zoonotic risk, across 9 animal families.
No subtype assumptions.
Full proteome.
90%+ accuracy.
A step toward proactive pandemic prevention.
Dr. Ceri Fielding retweeted
1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
biorxiv.org/content/10.64898…
Dr. Ceri Fielding retweeted
Comprehensive review on COVID-19: etiology, pathogenicity, and treatment. September 2025
frontiersin.org/journals/med…
Dr. Ceri Fielding retweeted
The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes
nature.com/articles/s41467-0… @NatureComms @a_pichlmair 🇩🇪
