@GuptaR_lab

Ravi Gupta is Hong Kong Jockey Club Professor of Global Health, University of Cambridge. TIME100 Most Influential 2020; Clarivate Highly Cited Researcher

 Cambridge, United Kingdom
citiid.cam.ac.uk/ravindra-gupta/
Joined February 2017
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The first evidence of in vivo SARS-CoV-2 escape from antibodies: emergent Spike deletion H69/V70 and D796H mutation in a convalescent plasma (CP) treated patient. These mutations conferred reduced susceptibility to the CP and sera from multiple donors. medrxiv.org/content/10.1101/…

Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion

SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are designed...

medrxiv.org
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Long thread on bioRxiv paper co-authored with #ListerFellow @GuptaR_lab. New mutation patterns in SARS-CoV-2 from patients with chronic infection. Evidence of CD8 T cell-escape and adaptation to tissue compartments outside the upper-respiratory tract. biorxiv.org/content/10.64898…

Coevolving Mutations in Chronic SARS-CoV-2 Infections

The SARS-CoV-2 pandemic has been marked by two outstanding features that have had major impacts on global public health: the repeated emergence and growth of highly divergent saltation variants with...

biorxiv.org
Ryan Hisner@LongDesertTrainJul 16
ORF6 is a SARS-2 protein that shuts down traffic between the nucleus & cytoplasm in host cells, inhibiting host mRNA export & immune responses. But in all variants since early 2023, ORF6's abilities are hampered by the ORF6:D61L mutation. Two newish ORF6 observations.... 1/15
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#2: Mutations overrepresented in chronic seqs (relative to circulating seqs) are almost certainly functionally meaningful—e.g. Ab evasion, T-cell evasion, or adaptation to a tissue type. See new preprint by me, Darren Martin, & @GuptaR_lab on this. biorxiv.org/content/10.64898… 7/

Coevolving Mutations in Chronic SARS-CoV-2 Infections

The SARS-CoV-2 pandemic has been marked by two outstanding features that have had major impacts on global public health: the repeated emergence and growth of highly divergent saltation variants with...

biorxiv.org
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Once again, for those not already aware, clinical academics contribute to both the health and wealth of the UK. We need to be supporting them and growing their number not hastening their extinction. #ClinicalAcademicCrisis
Charlotte Summers@charlot_summers15 Feb 2024
There is a crisis in clinical academia in the UK. We talk of the need to expand medical schools, embed research into the NHS to improve care, & the importance of a vibrant life sciences sector for the economy of the UK, & yet we seem unable to tackle the underlying issues 1/9
Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.

ALT Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.

Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.

ALT Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.

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Just back from a wonderful week in Singapore meeting old and new friends in the infectious diseases world - first stop NUS collaborators, the PSI pandemic science meet then the A star ID labs 5th birthday event. What a time to be in global health @hkjcghi
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Wonderful and exciting week here in Hong Kong for #NIDO2026 talking about Nidoviruses and pandemic/epidemic preparedness. Exciting times ahead utilising all resources available to generate critical evidence to inform practice! @hkjcghi @GuptaR_lab @MedCambridge
Gupta Lab@GuptaR_labJun 26
Meeting old and new colleagues in humid Hong Kong #nidovirus 2026. 3 talks from our lab today and one more to come from me at the GHI session. however, the team already presented most of the cool data👀. Time to zoom out for a global perspective! ⁦⁦⁦@hkjcghi⁩
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From vision to impact 🌍🚀 
At #NIDO2026, #HKJCGHI brought science, partnership & purpose into action. From Frank Konings’ global vision to Ravi Gupta’s insights on virus evolution— driving real-world impact.  💡 End-to-end preparedness = detection to vaccines to equity.
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Finally finished a long-gestating paper on mutation patterns in chronic infections (with co-authors Darren Martin & @GuptaR_lab) & it's now available in preprint form. Paper too long for 1 summary 🧵, but I'll do a cursory overview now, then 🧵s on subsections later. 1/16
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Another exciting day at #NidoVirus2026 with talks by great labs @GuptaR_lab @SystemsVirology @Lab_Rihn_th @weisssr @lucygthorne a @CEPIvaccines and more...
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Meeting old and new colleagues in humid Hong Kong #nidovirus 2026. 3 talks from our lab today and one more to come from me at the GHI session. however, the team already presented most of the cool data👀. Time to zoom out for a global perspective! ⁦⁦⁦@hkjcghi⁩
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Hearing about priority coronaviruses for preparedness from CEPI during an invigorating session largely around immune imprinting and virus shedding #nido2026 ⁦@hkjcghi⁩
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Wonderful to welcome the #HKJCGHI Cambridge team to Hong Kong for NIDO 2026—bringing everyone together for in-person research exchange, team building, and local culinary experiences.
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Our superstar Bo Meng delivering a killer talk on adaptation of SARS CoV 2 to use surface heparan sulphate for cell entry +tropism using primary human tissues and live viruses. a complex story delivered with clarity and precision during the #Nido2026 entry session⁦⁦⁦⁩
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Inspiring to see young members of the lab presenting their hard work from the past few years @ #nido2026. Four oral presentations to come from the lab in the coming days ⁦@hkjcghi⁩
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Super excited to be at the Nidovirus meeting in HK. We will be discussing CoV amongst others over the coming days ⁦@hkjcghi⁩
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Join the #HKJCGHI Sharing Session at #NIDO2026 to explore pandemic preparedness & the latest SARS‑CoV‑2 research with leading experts. More: nido2026.com
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Wow just heard about new clinical trials of a new drug for hep B infection at the European HIV hepatitis meeting - antisense oligo nucleotides showing promising results in those already taking nucleotide/side inhibitors. And for hep D a new entry inhibitor.@hkjcghi @MedCambridge
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Back to my HIV routes at the 4th European Meeting on HIV & Hepatitis in Barcelona, catching up with giants in the field of HIV drug resistance. Mpox on the menu here too and we look forward to soon sharing our data on mpox vaccine in people living with HIV. @hkjcghi
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Gupta Lab retweeted
Catherine@CatieZeeJun 10
In the Auckland region, children aged 0-4 years have had the highest cumulative rates for SARS-CoV-2 positive SARI hospitalisation this year. phfscience.nz/digital-librar…
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Japan: "COVID-19 still kills over 30,000 a year, even 3 years since the infectious disease was downgraded to the level of seasonal influenza" 🔹36,000 COVID deaths in 2024 🔹38,000 COVID deaths in 2023 COVID-19 was 8th cause of death in Japan, 2023-2024 asahi.com/ajw/articles/16560…

COVID-19 still kills over 30,000 a year in Japan; old people at risk | The Asahi Shimbun Asia &...

Annual deaths from COVID-19 continue to top 30,000 in Japan, even three years since the seriousness of the infectious disease was downgraded to the level of seasonal influenza.

asahi.com
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Very concerned about the state of final preparedness in light of New Ebola outbreak and hantavirus cruise ship incident. We are committed @hkjcghi and @MedCambridge to addressing preparedness against a range of pathogens, but funding needs to step up in a consistent way.
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