Tweets about biomedical sciences and finance. Ph.D., Not financial advice. Do your own research.
Joined March 2022
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Celling Alpha retweeted
UC Berkeley scientists identified a promising molecular compound that could lead to a new weight loss and diabetes treatment.
Unlike GLP-1s, it helps cells burn extra energy while preserving muscle, without changing food intake or exercise.
bit.ly/4xhpQTI
Celling Alpha retweeted
Today we announced a landmark partnership with @EliLillyandCo to use our AI models to design recombinases for genetic medicine—a collaboration valued at up to $2.25 billion before royalties.
The goal: use Profluent's AI models to design recombinase editors capable of inserting long stretches of DNA at precise locations in the genome.
Read the press release for more: businesswire.com/news/home/2…
Celling Alpha retweeted
A promising drug target for regenerating functional β-cell mass in diabetes!
@WorthamLab, @msanderlab & team @UCSanDiego discover the deacetylase SIRT2 restrains proliferation of pancreatic β-cells in a glucose-dependent manner: jci.org/articles/view/187020
The image shows labeling of SIRT2 (red), insulin (green), and nuclei staining (blue) in mouse pancreatic islet sections.
Celling Alpha retweeted
Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/S0092…
Celling Alpha retweeted
Unprecedented protection from malaria (90%) from a single shot vaccine: results of a small randomized trial @NatureMedicine
nature.com/articles/s41591-0…
nature.com/articles/s41591-0…
Celling Alpha retweeted
Scientists have designed a new form of insulin that can automatically switch itself on and off depending on glucose levels in the blood go.nature.com/3A14Yrk
Celling Alpha retweeted
Join us at the upcoming international Bradykinin Symposium, taking place in Berlin, Germany, Sept. 4-6. Data from the Phase 1 study in #hereditaryangioedema (#HAE) will be shared in two encore presentations. Don't forget to visit our HCP exhibit booth directly in front of the Lecture Hall. See you there! bradykinin-symposium.de/
#BradykininSymposium #CRISPR #geneediting
Celling Alpha retweeted
Rafael @ArrojoeDrigoLab and I are co-chairing the 10-year Human Islet Research Network Symposium on changing the course of #T1D in January 2025! For the first time, it’ll take place @NIH campus and be open to the public! Register now to secure your spot!
niddk.nih.gov/news/meetings-…
Celling Alpha retweeted
FDA approves third anti-amyloid antibody for Alzheimer disease bit.ly/3WaNReT
Eli Lilly’s donanemab (Kisunla) is now approved for early symptomatic Alzheimer disease.
Celling Alpha retweeted
We are pleased to share positive topline results from our HELIOS-B Phase 3 study of vutrisiran, an investigational #RNAi therapeutic in development for the treatment of #ATTR #amyloidosis w/ cardiomyopathy. Read the press release: bit.ly/3VwvRtY #RNAiTherapeutics #siRNA
Celling Alpha retweeted
Today we announced an important development regarding FDA approval of our gene therapy. Watch to hear a message from our CEO, Doug Ingram:
Celling Alpha retweeted
We believe that targeting the CD40L ligand pathway could be key to developing a new approach to #immunosuppression that represents a major advance in the standard of care for #transplant recipients. Learn more about our research: eledon.com/science/mechanism…
Celling Alpha retweeted
In the second chapter of their story, Shanna describes the symptoms of hereditary angioedema (#HAE) and the reality of living with this #raredisease. Learn more about their experience and the challenges they face. #GenomeJourney
Celling Alpha retweeted
In honor of #HAE Day, we are sharing Shanna’s story to help you learn more about this #raredisease. It took 4 years for Shanna to learn they had hereditary angioedema — years that included confusion and uncertainty. Learn more about HAE here: bit.ly/3ROZkP4 #active4HAE #GenomeJourney
Celling Alpha retweeted
Interesting podcast!
I made it out of the jungle alive ❤
This was an adventure of a lifetime, from getting lost in dense unexplored wilderness to taking very high doses of ayahuasca.
I'll post videos about some of these adventures in a week or so. First, here's a 4 hour podcast conversation with Paul Rosolie that we recorded deep in the jungle.
This time in the jungle has deepened my gratitude for getting to exist on this beautiful planet with all of you. I love you all ❤
The podcast conversation is here on X and is up on YouTube, Spotify, and everywhere else. Links in comment.
Timestamps:
0:00 - Introduction
2:07 - Amazon jungle
4:25 - Bushmaster snakes
15:51 - Black caiman
34:11 - Rhinos
37:25 - Anacondas
1:07:42 - Mammals
1:19:48 - Piranhas
1:30:38 - Aliens
1:48:23 - Elephants
1:56:21 - Origin of life
2:09:40 - Explorers
2:22:57 - Ayahuasca
2:31:22 - Deep jungle expedition
2:45:29 - Jane Goodall
2:48:00 - Theodore Roosevelt
2:58:56 - Alone show
3:08:42 - Protecting the rainforest
3:24:55 - Snake makes appearance
3:33:06 - Uncontacted tribes
3:46:30 - Mortality
3:47:58 - Steve Irwin
3:55:38 - God
Celling Alpha retweeted
The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.
We are pleased to announce that #FDA has cleared our IND application for PM359 for the treatment of chronic granulomatous disease (CGD), enabling Prime to initiate its Phase 1/2 clinical trial in the US. Details: investors.primemedicine.com/… $PRME
Celling Alpha retweeted
Imagine a US Congress waving flags to celebrate allocation of $95 Billion for defeating a severe disease? Investing in the fight for cures would save lives. Our country and the world would be far better served by such leadership. Financial commitment to sustaining conflict elsewhere and viewing much of the planet as an adversary is not a strategy that can be successful long term.
Celling Alpha retweeted
The study shows that protein kinase CK2 is critically involved in #glucagon expression. It therefore may represent a promising platform for the development of new #glucoselowering drugs. #Diabetes #Islets #Alphacells tinyurl.com/4fy32xsp 🔓
Celling Alpha retweeted
Madrigal is proud to announce the approval of the first and only therapy in NASH/MASH. Learn more about the milestone by reading our press release: bit.ly/3Pmyqwr #NASH
Celling Alpha retweeted
Today, FDA approved a medication for the treatment of adults with noncirrhotic non-alcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), to be used along with diet and exercise. fda.gov/news-events/press-an…