@msanderlab
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Max Delbrück Center for Molecular Medicine, Berlin and Sanford Consortium for Regenerative Medicine, San Diego
Berlin and San Diego
Joined March 2017
- Tweets566
- Following118
- Followers1.7K
- Likes886
Maike Sander & Lab retweeted
A promising drug target for regenerating functional β-cell mass in diabetes!
@WorthamLab, @msanderlab & team @UCSanDiego discover the deacetylase SIRT2 restrains proliferation of pancreatic β-cells in a glucose-dependent manner: jci.org/articles/view/187020
The image shows labeling of SIRT2 (red), insulin (green), and nuclei staining (blue) in mouse pancreatic islet sections.
We are recruiting a postdoctoral researcher @MDC_Berlin
iPSC islet cell models
High throughput screens in iPSC models
Organ-on-a-chip
Genomics and computation
Please RT! DM if you want to learn more.
mdc-berlin.de/career/jobs/po…
I look forward to an exchange of science with colleagues at Heidelberg University. It’s been a while - I graduated from Heidelberg University in 1994.
Join us for a talk by Maike Sander on "Understanding and Treating Diabetes with Islet Stem Cell Models" April 29, 2024 16:00, BioQuant, SR41
@UniHeidelberg @uniklinik_hd @msanderlab @MDC_Berlin
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Very honored to join the @ChariteBerlin faculty. I look forward to the work ahead with wonderful colleagues.
On March 1, our Scientific Director Maike Sander (@msanderlab) will take up her appointment as professor for "Pancreatic Organoid Research and Disease Modeling" at @ChariteBerlin. Dean Joachim Spranger presented her with the certificate. Congratulations!
mdc-berlin.de/sander
ALT Maike Sander and Joachim Spranger with the certificate
ALT Maike Sander and Joachim Spranger with the certificate
Congratulations to @WorthamLab and the many other contributors. The study identifies Sirtuin-2 as a glucose-dependent regulator of beta cell proliferation.
I’m excited to share our discovery of a novel regulator of adaptive beta cell proliferation–the protein deacetylase SIRT2–from work in @msanderlab together with many key contributors including Bastian Ramms, Chun Zeng, Jackie Benthuysen, and @someshtweet biorxiv.org/content/10.1101/…
Maike Sander & Lab retweeted
Thrilled to announce that registration and abstract submission for European Islet Study Group meeting in Helsinki, Finland, 18-20 June 2024 is NOW OPEN! helsinki.fi/en/conferences/e…
🚨Early-bird registration is March 15th, limited seats available🚨
Please RT ;)
Very much look forward to my upcoming visit to @CRGenomica - to learn about the outstanding science and to visit our @EULIFE_news partner institution. Of course, also to experience beautiful Barcelona.
📣 PRBB-CRG conference
📋 Insights into diabetes from stem cell islet organoids and single-cell genomics
🗣️ Maike Sander @msanderlab
📆 Jan 12
⏰ 12:00 CET
🤝Hosted by Jorge Ferrer, CRG
📍Marie Curie room #PRBB
Out today @NatureGenet our work on mechanisms of beta cell dysfunctions in type 2 diabetes (T2D) combining single-cell genomics and Patch-seq. Congratulations to @GaoweiW @JoshChiou, Chun Zeng. Big thanks to @kjgaulton @seb11pr @bcellorg, F Kandeel, S Kim.
rdcu.be/dcZQs
The @MDC_Berlin is seeking a Head of Innovation & Commercialization. An opportunity to shape a modern innovation office.
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DM me with any questions.
#NowHiring: join the #mdcBerlin as "Head of Innovation & Commercialization" and advise our scientists in creating industry alliances or spin-off companies.
📢 permanent, full-time position with great compensation and benefits‼️
𝗔𝗣𝗣𝗟𝗬: mdc-berlin.de/career/jobs/he… #JobOpening
ALT Graphic for a job opening at the Max Delbrück Center: Head of Innovation and Commercialization (Technology Transfer) (f/m/d). Apply by May 31, 2023. Located on the Campus Berlin-Buch.
Maike Sander & Lab retweeted
Retweeting our call for senior scientist or postdoc at the Max Delbrueck Center in Berlin with correct link to application website.
1. iPSC-islet organoids
2. Metabolomics
3. Single-cell biology and screens
mdc-berlin.de/career/jobs/se…
Maike Sander & Lab retweeted
It was a pleasant surprise to see the commentary on our recent JCI paper by @powersac_TN and Kristie Aamodt who provide an apt metaphor for the regulatory layers of beta cell function jci.org/articles/view/169718. Thanks for highlighting! Original article here: jci.org/articles/view/165208
We are thrilled to share our single-cell genomics analysis of stem cell islet differentiation in Dev Cell:
authors.elsevier.com/a/1gua-…
Congratulations to Han and Gaowei, who led this study, and thank you to collaborators @LabSpagnoli @kjgaulton @powersac_TN 1/2
Retweeting our call for senior scientist or postdoc at the Max Delbrueck Center in Berlin with correct link to application website.
1. iPSC-islet organoids
2. Metabolomics
3. Single-cell biology and screens
mdc-berlin.de/career/jobs/se…
Maike Sander & Lab retweeted
Join @msanderlab as a #postdoc! It aims to understand & reverse pancreatic beta cell dysfunction in #diabetes. It employs #hPSC-based models and interrogates these models combining functional & #singlecell based genomic assays. #postdocjobs
👉mdc-berlin.de/career/jobs/se…
ALT Senior research scientist / postdoc (F/M/D) Apply by April 30, 2023 Sander Lab
Join our team @MDC_Berlin as senior scientist or postdoc!
1. iPSC-islet organoids
2. Metabolomics
3. Single-cell biology and screens
recruitingapp-5471.de.umanti…
Maike Sander & Lab retweeted
Helmholtz delegation visit to Sydney. Wonderful discussions with a perfect view of Sydney harbor. @KatrinJM @msanderlab
We’re thrilled that our work on epigenomic regulation of adaptive insulin secretion is out @jclinicalinvest! A massive effort led by @WorthamLab, who will continue this research as faculty at UCSD. Thanks to @kjgaulton, @HuisingLab, Christian Metallo. 1/3
jci.org/articles/view/165208
We found that feeding increases H3K27 acetylation in pancreatic islets, and that the chromatin modifying enzyme Lsd1 mediates deacetylation of these sites between meals. Experimental manipulations that prevent resetting of feeding-induced changes cause insulin hypersecretion. 2/3
Sites of LSD1 recruitment in human islets are enriched for T2D-associated variants, revealing a potential mechanism whereby genetic background influences adaptive insulin secretion. Stay tuned to @WorthamLab who will continue this exciting research. Much more to come! 3/3