Rooky Tuesday! 🔬 Warty dyskeratoma 😎🫡💪 🥣 Cup-shaped, keratin-filled follicular invagination ✂️ Suprabasal acantholysis with villi 🎯 Dyskeratosis: corps ronds & grains 🔍 Differentials • Acantholytic dyskeratotic acanthoma: lacks follicular cup • Darier/Grover disease: clinical distribution • Acantholytic SCC: atypia & invasion #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

24-year-old man with a wrist lesion, being evaluated for Mohs 🙂 Blue nevus–type melanocytoma is currently divorcing itself from PEM on molecular grounds: 🧩 Biphasic: dendritic blue nevus + cellular ovoid/spindle component 🧬 GNAQ/GNA11 pathway #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

🔬 Interested in dermpath? This is the path forward! 🎓 ASDP Mentorship Award: Two weeks with any ASDP full-member mentor (not just the list provided 👇🙃; funding up to $3,000. 📅 Apply Oct 15 to Dec 15 👉asdp.org/ASDP/ASDPWeb/Physic… #dermpath #ASDP26 #PathTwitter #DermTwitter #pathresidents #FutureDermpath #Mentorship @ASDPTweets @TheUSCAP @Pathologists @ColumbiaDerm

🔬TRBC1 clonal pattern — outscope your mentor! 1.Read the article 👇 Free download for 50 days. 2.Spot the clone first 👀 3.Realize your preceptor is mortal! 4.Graduate& 🎓 Move on 😄If I could do it, so can you! sciencedirect.com/science/ar… #CTCL #pathologists #pathTwitter #dermpath #dermatology #dermtwitter #pathology @ModernPathology @TheUSCAP @MassGenBrigham

Part II: 🔥📷 Hello, Dermpath world! Would you buy these as flame figures? 📷#pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

🔥🔬 Hello, Dermpath world! Would you buy these as flame figures? 👀 #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

🔬 Granular cell tumor — high-yield pearls 📍 Clinical • Solitary, slow-growing, firm nodule • Head/neck common, especially tongue 👅 • Usually benign; malignant tumors are rare 🧫 Histology • Poorly circumscribed, infiltrative dermal/subcutaneous neoplasm • Large polygonal cells with abundant coarse eosinophilic granular cytoplasm • 🔥 Granules = numerous intracytoplasmic lysosomes/autophagolysosomes • PASD+, diastase-resistant granules (do you know anybody who does it?) • Cells dissect between collagen bundles and may involve nerves or skeletal muscle • Overlying pseudoepitheliomatous hyperplasia may mimic SCC ⚠️ 🧬 IHC • Conventional granular cell tumor = Schwannian, S100+/SOX10+ • Non-neural granular cell tumor = non-Schwannian, S100−/SOX10− #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

I think the full-article pre-proof is available for all the CTCL adorers! This is the first article in Dr. Gru’s series on real-world experiences. Stay tuned!🔬👇sciencedirect.com/science/ar… #CTCL #Lymphoma #Dermatology #Dermatopathology #TRBC1 @alegru18 @MPulitzerMD @TorresCabalaMD

🟡 Verruciform xanthoma 👀 Often looks like a wart clinically: solitary, slow-growing, verrucous/papillomatous plaque or nodule, classically oral or anogenital. 🔬 Histo: verrucous/psoriasiform hyperplasia + hyperparakeratosis ± neutrophils. 🫧 Don’t miss the clue: foamy macrophages packed superficially in the papillary dermis between rete ridges. 💡 Wart-like lesion + superficial foam cells → think verruciform xanthoma. #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter

Going into derm? This one’s for you! 👇 Skip it if you’re just derm-curious or a total beginner 🙂 🔬 Histo: Psoriasiform dermatitis (see below). 👀 Clinical: they really want eczema! 🧠 Beyond morphology: Can we really see everything on H&E? How many stains/ancillary are enough? There is always some sponge around the corner! 🧬 Cytokine ISH : NOS2 and IL17 were positive, supporting psoriasis and consistent with the histopathology. IL13 and IFNG were negative (attached table for expression patterns). 🔬 Histo is king—but not the whole kingdom anymore! #pathology #pathologists #pathTwitter #dermpath #dermatology #dermtwitter