Laboratory of Metabolic Dynamics in Cancer @UniBarcelona @BiologiaUB @PCB_UB @IBUB_UB
Barcelona, Spain
Joined March 2021
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Our last work together with @MostoslavskyLab is finally out! Really thankful to all people involved @MGHCancerCenter @harvardmed @fpoirccs and the members of @CSebastianLab @fpoirccs @UniBarcelona @IBUB_UB @PCB_UB.
nature.com/articles/s41467-0…
CSebastianLab retweeted
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja!
nature.com/articles/s41586-0…
CSebastianLab retweeted
What happens when tumor cells can't find enough nutrients? They "call" other cells. We have found a new mediator of this phenomenon: the multifunctional cytokine LIF 👇
CSebastianLab retweeted
SIRT6 decline throws Off Mood, Sleep, and Cognition.
rdcu.be/eTvJj
Tryptophan byproducts build proteins, NAD+, and neurotransmitters (serotonin and melatonin). Yet, in aging and neurological disease, this balance is lost, leading to impaired mood, learning, and sleep.
CSebastianLab retweeted
Compilation of articles about metabolism and cancer published in October 2025. A lot of interesting papers! My favorite,
"Acidosis orchestrates adaptations of energy metabolism in tumors" (of the pancreas)
science.org/doi/10.1126/scie…
metabolist.wordpress.com/
CSebastianLab retweeted
We’re happy to share our new study out today @NatureCellBio
We show that a chromatin factor, ZNF280A, is required for DNA double strand break repair, linking its absence to clinical features in 22q11.2 distal deletion syndrome.
@MostoslavskyLab
nature.com/articles/s41556-0…
CSebastianLab retweeted
Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to @ThomasLClarke for leading the project!
nature.com/articles/s41556-0…
CSebastianLab retweeted
🚨📢Fresh off the press and featuring new exciting experiments! 🧪
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling
doi.org/10.1016/j.stem.2025.…
B2B with @VillarongaAlba @teamstembryo : doi.org/10.1016/j.stem.2025.…
Can metabolic processes instruct cell fate decision making during embryonic development?
In our new preprint, we show an important role of glycolytic activity for the development of endoderm and mesoderm through the regulation of Nodal and Wnt signalling.
biorxiv.org/content/10.1101/…
CSebastianLab retweeted
No us perdeu aquesta nova reunió (la 32a) @MetNet_Bcn . Us esperem com sempre a l'IEC!
#Trobada MetNet | On es fomenta l’intercanvi d’idees sobre la regulació metabòlica i el seu impacte en malalties com l’obesitat, la diabetis, patologies cardiovasculars, neurodegeneratives i el càncer.
🔗Per a més informació i inscripcions tuit.cat/mQU2m
CSebastianLab retweeted
📢Our last research is online! 🎉
Amazing work spearheaded by @Nguyen_TBN✨
Grateful to @kwf_nl @oncodeinstitute
Exciting times at Center for Molecular Medicine @Cancer_UMCU Utrecht. #CancerResearch #CancerMetabolism #Lactate #StemCells #Organoids
cell.com/cell-metabolism/ful…
CSebastianLab retweeted
!THREE OPPORTUNITIES TO JOIN US!
We are looking for 3 (!!!) PhD students interested in
how Metabolism affects Genome Regulation.
Join us at @carrerasIJC as @MSCAactions fellow.
More info:
2 x experimental: nuclear-dn.eu
1 x computational: hubmol.eu
CSebastianLab retweeted
Join our research team at University of Barcelona! We are looking for candidates to apply for a PhD position focused on mitochondria, aging and metabolism.
💡 Requirements: Academic grade >8
📅Deadline: Feb 14th
If you are interested, contact me by DM
ub.edu/beques/3rcicle/PREDOC…
CSebastianLab retweeted
Check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 @NatRevMCB
! SharedIt link for free access: rdcu.be/d5ppE #circadian #metabolism
Circadian clocks constantly communicate to preserve tissue homeostasis, but ageing compromises the mechanisms that enable this crosstalk. Want to learn more? In our new review, @JacobSmithSci, Pura, Salva and take a dive into all things clock communication nature.com/articles/s41580-0…
CSebastianLab retweeted
Interested in how innate immune cells adapt to survive and thrive in different environments? We are looking for a #postdoc (fully ERC-funded) to strengthen our team @IRBBarcelona! Reach out to me and apply at recruitment.irbbarcelona.org…
CSebastianLab retweeted
Weekend reads?
Metabolism and cancer at the MetaboList
metabolist.wordpress.com/202…
CSebastianLab retweeted
I am happy to share that @molecular_guy paper is online! rdcu.be/dZwAN
We can imagine REST and SIRT6 as a rowing team. In healthy brains, they work together, moving forward and protecting brain function.
CSebastianLab retweeted
L’ecosistema públic d'R+D+i del #ParcCientíficdeBarcelona capta 70M€ el 2023, un 40% més que l'any anterior 💪 ▶️ bit.ly/3Uly3EU
@UniBarcelona @IBECBarcelona @IBMB_CSIC @IRBBarcelona @IBUB_UB @CSebastianLab @Eva46653369 @Creatio_UB #BioNMRGroup @QuimicaUB #PCBCommunity #RecercaUB
Last Friday took place the award ceremony of the Fundación Olga Torres research projects (call 23/24) at the Reial Acadèmia de Medicina de Catalunya. We'd like to thank the F.O.T. and its president @OncoBellmunt for funding our project and supporting our research on colon cancer
CSebastianLab retweeted
Here it is! Our paper on how protein deacetylase SIRT7 promotes B cell development is out today in @NatImmunol. Such a honor to contribute to this work with @vaquerolab and amazing PhD student Andrés Gámez. Many thanks to all collaborators!! nature.com/articles/s41590-0…
