Molecular Biologist, DNA repair, sirtuins, ageing and Neurodegeneration
Joined March 2017
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SPARK-ID: Dynamic DSB-sensor interactomes reveal modular nuclear repair networks coordinated by connector proteins biorxiv.org/content/10.64898…
Alfredo is one of the most talented people I have worked with; he created this amazing resource. It will help us understand how the cell coordinates the DSB response depending on the dynamic interactome of the sensor (HR, NHEJ), give us insight into the topological organization
Some overlapping interactomes of SIRT6, MRE11, and KU80 reveal a conserved repair core alongside sensor-specific specialisation. The shared core functions, combined with distinct individual proteins, make the system robust, reducing the DDR's dependence on any single protein
As an example we deepen our understanding on NCL as an important gatekeeper. So much work so much information as a resource, just read the preprint and play withe the network website, that is in beta mode: sparkid.bgu.ac.il
Why'd you have to go and make things so complicated? Simplicity as a Lens: A New Way to Model Brain Aging. biorxiv.org/content/10.64898… our latest preprint! #AgingResearch #Neuroscience #Alzheimers #SIRT6 #biotech
Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik,
@EremenkoEkater2
Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva
Why'd you have to go and make things so complicated?
Simplicity as a Lens: A New Way to Model Brain Aging.
biorxiv.org/content/10.64898…
See our latest preprint!
#AgingResearch #Neuroscience #Alzheimers #SIRT6 #BioTech
Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik, @EremenkoEkater2 Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva
SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling - Stein - 2026 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/…
Debbie Toiber retweeted
Genluminati follows a group of young scientists who invent a DNA-based religion as a cynical experiment—only to lose control of it when belief spreads, and a prophet emerges. Did the concept begin as #satire for you, or did you always see it turning dark?
wp.me/p3cyvH-LYH?utm_campaig…
Check out this book recommendation from Literary_Titan: bookbub.com/reviews/20329201… via @Bookbub
Debbie Toiber retweeted
🟠 For the full article>>
nature.com/articles/s41467-0…
SIRT6 decline throws Off Mood, Sleep, and Cognition.
rdcu.be/eTvJj
Tryptophan byproducts build proteins, NAD+, and neurotransmitters (serotonin and melatonin). Yet, in aging and neurological disease, this balance is lost, leading to impaired mood, learning, and sleep.
Crucially, we show that this damage isn't permanent. By inhibiting the enzyme TDO2 in our SIRT6 knockout fly model, we were able to significantly reverse both neuromotor decline and vacuolar formation, indicating a powerful therapeutic window.
