Brian V. Geisbrecht Laboratory at K-State. We use physical biochemistry methods to study the innate immune system. Papers not preprints.

Manhattan, KS USA
Joined September 2019
Brian V Geisbrecht Lab retweeted
In a #TopRead from @bvglab at @KStateResearch, data show that Efb-C binding to C3b exerts additional inhibitory effects on the central complement components beyond blocking formation of the C3 proconvertase alone. Learn more: ow.ly/yzsN50Z19xU.
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Brian V Geisbrecht Lab retweeted
Excited for the 18th Int'l Conference on Complement Therapeutics in Sissi, Crete, Greece 🇬🇷 A big thank you to our sponsors for their support. Your contribution helps bring together the complement community to share the latest advances in therapeutics and research. There are still registration spots available at the early fee. Late-breaking abstract submissions are open, and trainees and young investigators are encouraged to apply for travel awards by April 15. See our sponsors: aegeanconferences.org/confer… #Complement #Therapeutics #Immunology #Conference #Crete #Greece #TravelAwards #CallForAbstracts
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Brian V Geisbrecht Lab retweeted
Registration now available online: 18th Int'l Conference on #ComplementTherapeutics aegeanconferences.org/src/Ap…
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Brian V Geisbrecht Lab retweeted
Congratulations to all the trainee awardees! Great Work! Great Science! 17th Int’l Conference on #Complement Therapeutics.
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Brian V Geisbrecht Lab retweeted
Program Available: 17th Int'l Conference on #ComplementTherapeutics from May 10-15, #Sissi #Crete #Greece aegeanconferences.org/src/Ap…
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Brian V Geisbrecht Lab retweeted
It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on NIH-funded research—that’s all 210 drugs. But what the public sees is just the tip of the iceberg. Pharma takes credit for the final product, but beneath each drug developed, there are ~20 years of basic research, and 90% of the cost is from basic research funded by the NIH, which discovers drug targets, understands disease mechanisms, and creates life-saving treatments. Figuring out how cancer evades the immune system, how addiction rewires the brain, and how heart disease develops is the role of the NIH, creating the foundation for the breakthrough drugs that come 20 years later, and the NIH does all that with only 0.8% of the US budget. Without NIH, there would be no cancer immunotherapy, no anti-overdose medication, no anti-heart attack or stroke medication, no cutting-edge treatments. If NIH funding is cut, the iceberg will melt. That means fewer cures, more suffering, and more lives lost. The science beneath the surface keeps us afloat. Invest in NIH. Invest in life
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Brian V Geisbrecht Lab retweeted
Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a public database funded by US taxpayers. Every structural biologist in the world that deposited their structure to the PDB indirectly helped train alpha fold.
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Brian V Geisbrecht Lab retweeted
Former #JI_Editor @BvgLab @KStateBMB: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide as a new class of small-molecule #complement C1s inhibitor #ReadTheJI #immunology 👉 ow.ly/4GWV50QzEil
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Brian V Geisbrecht Lab retweeted
The first Legacy award for Complement Research was awarded today to Piet Gros by the @ComplementSoc International Complement Society at an online symposium in his honor. We celebrated his amazing contribution to the Structural Biology of Complement. Congratulations 🎊 Piet!
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Brian V Geisbrecht Lab retweeted
Finally, a note on peer review that is currently so criticized. This work shows why peer review works! The experiments suggested by the reviewers led to a profound revision of our initial model! Without the pressure of an honest and firm peer review we would have gotten it wrong.
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Brian V Geisbrecht Lab retweeted
1/3 Excited to share our latest research by the talented Dr Xaria Li on cell-intrinsic C5a in pathogen sensing and fungal killing. Out now in PNAS @PNASNews pnas.org/doi/10.1073/pnas.23…
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Brian V Geisbrecht Lab retweeted
This is going to be game-changing. We have launched a multidisciplinary hiring initiative at @KState to recruit 12 new faculty in biomanufacturing, supporting biosciences, and enabling technologies. Join us! k-state.edu/biomanufacturing… #NextGen #KState #biomanufacturing
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Brian V Geisbrecht Lab retweeted
Thrilled to present our manuscript out today in @CellCellPress. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. doi.org/10.1016/j.cell.2023.…
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Brian V Geisbrecht Lab retweeted
How can we condense the expanding universe of #complementbiology into the confines of a few pages? Here's our humble attempt. Grateful to @LambrisJD & George Hajishengallis and to all colleagues whose transformative research has thrust this field forward! nature.com/articles/s41577-0…
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Brian V Geisbrecht Lab retweeted
SAVE THE DATE: June 11-16, 2024. 16th Int'l Conference on #Complement #Therapeutics. Loutraki, Ancient Corinth, Greece aegeanconferences.org/src/Ap…
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Brian V Geisbrecht Lab retweeted
A new study using the @SomaLogic affinity #proteomics platform: Activation of the Complement and Coagulation Systems in the Small Airways in Asthma karger.com/res/article/doi/1…
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Brian V Geisbrecht Lab retweeted
Seek Sunday: Erika Geisbrecht, professor of biochemistry & molecular biophysics, is studying fruit flies to understand diseases like Alzheimer's & Parkinson's or muscular disorders like myofibrillar myopathy. k-state.edu/seek/spring-2023… @KStateBMB | @KStateArtSci | @KStateResearch
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Brian V Geisbrecht Lab retweeted
As far as I'm concerned, this will never ever stop being funny. 😂
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Brian V Geisbrecht Lab retweeted
Thrilled to finally see this in @BloodJournal!!! ✅Our work on the potential role of calcium in structure & function of complement factor I Very grateful to @pozzilab for collaboration 🙏 Quick thread to share with you all what we found 👇 sciencedirect.com/science/ar…
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