Cryo-electron microscopy, structural biology of molecular machines, ribosome-associated processes
Heidelberg, Germany
Joined October 2020
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We are excited to share our latest work elucidating the structural basis for how augmin binds to microtubules. Out just now @NatureComms:
nature.com/articles/s41467-0…
Nearly two decades after augmin's discovery in Drosophila, we have reconstituted the microtubule-binding region of the Drosophila augmin complex on microtubules and demonstrate the conserved mechanism by which the augmin subunit HAUS6 orients augmin for microtubule branching.
Congratulations to the shared first authors @martin_wuertz and Giulia Tonon! Fantastic collaboration with the Schiebel Lab @ZmbhH, @FabioLolicato at the BZH Heidelberg, @EustermannLab @embl, and the Erhardt Lab at KIT Karlsruhe. Thanks to all who contributed!
Out just now at @NatureComms: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells:
nature.com/articles/s41467-0…
Great collaboration with the Melnikov Lab @SergeyVMelniko1 @UniofNewcastle and the Hill Lab @chillzaa @YBRI_UoY. Congratulations to all authors, in particular the shared first authors Karla Helena-Bueno and Sophie Kopetschke @S_Kopetschke.
Stefan Pfeffer retweeted
1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation: nature.com/articles/s41467-0…
Online today at @NatureComms: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: nature.com/articles/s41467-0…
A great collaboration with the Schiebel Lab @Zmbhh
@UniHeidelberg and the Gruss Lab @UniBonn. Congratulations to all authors, in particular the shared first authors Qi Gao, Florian Hofer, Bram Vermeulen @BramV98 and Sebastian Filbeck!
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s41467-0…
Great collaboration with the Schiebel and Mayer Labs @Zmbhh @UniHeidelberg. Congratulations to all authors, in particular the shared first authors Anjun Zheng, Bram Vermeulen @BramV98
and Martin Würtz @martin_wuertz.
Stefan Pfeffer retweeted
Congratulations to Martin Würtz, who yesterday received the Nikon Young Scientist Award 2024 for excellent research in cell biology awarded by the German Society for Cell Biology.
We have an open PhD position to explore structures of gamma-tubulin ring complexes using cryo-EM approaches here in our group @ZmbhH
@UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD : hbigs.uni-heidelberg.de
We still have open PhD positions here in our cryo-EM group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School or directly send us your application documents.
hbigs.uni-heidelberg.de/
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
Out just now @embojournal: our cryo-EM structure of the native RanGTP-induced γ-TuRC-capped microtubule, revealing a surprisingly asymmetric minus end architecture with direct implications for microtubule regulation and modulation during spindle assembly.
embopress.org/doi/full/10.10…
Great collaboration with the Schiebel Lab @Zmbhh @UniHeidelberg and the Gruss Lab @UniBonn. Congratulations to all authors, in particular the shared first authors Bram Vermeulen @BramV98, Anna Böhler and Qi Gao @QIGAO31314616.
We still have ERC-funded PhD positions open in the lab! If you are interested, please apply!
We have three open PhD positions funded under our #ERCStG 'RiboStress' to explore how cells remodel the activity and molecular organization of the translation machinery in response to stress.
If you are interested apply via the HBIGS graduate program: my-hbigs.uni-heidelberg.de/s…
We have three open PhD positions funded under our #ERCStG 'RiboStress' to explore how cells remodel the activity and molecular organization of the translation machinery in response to stress.
If you are interested apply via the HBIGS graduate program: my-hbigs.uni-heidelberg.de/s…
Stefan Pfeffer retweeted
If you want to read a short summary of the projects of the three new @ERC_Research Grantees #ERCStG Daniela Duarte Campos, Kerstin Göpfrich @KGoepfrich, and Stefan Pfeffer @PfefferCryoLab based @ZmbhH visit:
uni-heidelberg.de/en/newsroo…
Stefan Pfeffer retweeted
Fünf ERC Starting Grants gehen an die Universität Heidelberg – Europäischer Forschungsrat fördert Vorhaben in der Molekularen Biologie, der Malaria-Forschung und der Astronomie mit insgesamt rund 7,5 Millionen Euro uni-heidelberg.de/de/newsroo…