Associate Professor of Hematology @UnivPoliMarche. Husband of @GeorgiaColle, father of 👶🏼.
Ancona, Marche
Joined May 2012
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Seeing this come out is incredibly rewarding. A true paradigm shift for the NPM1 field — thank you for the opportunity to keep collaborating!!! Congrats to @Gandhar_Datar and @sciencyelmira for the immense work done.
Lorenzo Brunetti retweeted
Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!
(1/10) How do diverse leukemia mutations converge on the same molecular program?
In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧
Lorenzo Brunetti retweeted
@Gandhar_Datar joined the lab when the world was shutting down, having just gotten started with guidance from @therealDrGundry and @BrunettiLab, who then moved on in their careers. Tough work in isolation until @RibackLab joined @bcmhouston, when informal chats got us thinking about the project in a whole new way. We considered how the aberrant function of NPM1c was related (or not) to its nucleolar WT function. A great collaboration grew, with Gandhar deeply learning both hematology and biophysics! Many ppl world-wide contributed and @sciencyelmira was the closer, getting the in vivo models working. Thanks to all, including the reviewers and editors for feedback.
(10/10) Thank you to everyone in the @RibackLab and @Goodell_Lab, especially to @sciencyelmira, for this amazing work, and to @theNCI, @CPRITTexas, @LeukemiaRF, Searle Scholars, Ted Nash Long Life Foundation, and @BCM_MSTP for essential funding support.
Lorenzo Brunetti retweeted
Lorenzo Brunetti retweeted
Excited for our session on critical trial appraisal here at #EHA2025 in Amber 7&8 - @Capt__Kirkwood on randomisation
- @ComeBommier on surrogate endpoints
- me on postprogression care & overall survival
- Fabio Efficace on patient reported outcomes
#lymsm
Lorenzo Brunetti retweeted
A/Prof @Capt__Kirkwood give us some great examples from within haematology of the importance of randomization & types of bias that can crop up in its absence (and occasionally in its presence!)
#EHA2025 @young_eha
Lorenzo Brunetti retweeted
Before you go on Xmas holidays remember
👇👇👇
Deadline for abstract submission to join us at #EHAReCon2025 in Malaga on March 17-20 is January 8th !!
I will be chairing the session on Transcripitional control with this fab lineup of speakers 🤩
@young_eha
Lorenzo Brunetti retweeted
1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! nature.com/articles/s41556-0…. 🧵 below:
Lorenzo Brunetti retweeted
Our team @SCICambridge is expanding and we have now a very exciting opening for a Laboratory Research Technician/Assistant!!!
More positions to be announced very soon.
Help us spread the word 👇👇🔬🔬
jobs.cam.ac.uk/job/47567/
Lorenzo Brunetti retweeted
Today, at TLH, we summarise a decade of hard work. We wish to thank all colleagues, patients and relatives, who helped us during this amazing journey.
thelancet.com/journals/lanha…
Lorenzo Brunetti retweeted
"We are convinced that #academic CAR T-cell therapy will play an increasingly important role in cancer therapeutics... It would be unfair to leave our patients to their own devices when there is so much we can do for them"
In Focus #CARtx @hospitalclinic thelancet.com/journals/lanha…
Lorenzo Brunetti retweeted
Lots of #MRD studies presented at #EHA2024
Many investigators consider MRD as a surrogate endpoint, although not validated in many indications.
Please read/share this review. Might help understand concept and current evidence.
Agree @VPrasadMDMPH ?
ashpublications.org/blood/ar…
Lorenzo Brunetti retweeted
An entire session dedicated to #palliativecare at #EHA2024. Proud of what we have achieved with the @young_eha committee! 🌱@EHA_Hematology
Lorenzo Brunetti retweeted
Just got a coffee at #EHA2024 (thanks @sanofi ) and I was told I was the first person to ask for a coffee in a reusable cup.
So come on everyone, bring your own cups next year to reduce waste and create a more sustainable congress ! @young_eha @EHA_Hematology
An entire session dedicated to #palliativecare at #EHA2024. Proud of what we have achieved with the @young_eha committee! 🌱@EHA_Hematology
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