The Di Stefano Lab. Post-transcriptional control of cell fate and oncogenesis. Associate Professor & Vivian L. Smith Chair @BCMHouston. Views my own.
Boston, MA
Joined June 2018
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1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s41587-0…
Bruno Di Stefano retweeted
Excited to share our new preprint! ChromE-seq reads 3D chromatin and gene expression in one cell. Across ~400,000 human primary cells, B lineage has the fewest chromatin loops and is most perturbed in trisomy 21, driving the B-cell block in Down syndrome.
biorxiv.org/content/10.64898…
Bruno Di Stefano retweeted
Happy to share our latest preprint in collaboration with @BashorLab. Great work by first author Alena Streletskaia. biorxiv.org/content/10.64898…
ALT Circular stem cell colonies with BMP activated on one side. Brachury and N-CAD positive cells are seen migrating from the light-induced source.
Bruno Di Stefano retweeted
🚨 NEW ISSUE ALERT!!! 🚨
New Research articles online now at Genes & Development!
Also in this issue, an Outlook on ATR in translesion synthesis, and a Review about the mechanisms controlling stem cell state exit.
Click here to learn more:
➡️ genesdev.cshlp.org/content/4…
Bruno Di Stefano retweeted
🆕 ADVANCE ONLINE 🆕
REVIEW: Mechanisms coordinating exit from the stem cell state in mammals
By Park, Levin-Ferreyra and Bruno Di Stefano
➡️ ow.ly/Ynlm50Za9Wc
@DiStefano_Lab @bcmhouston
#stemcell #embryogenesis #celldifferentiation
Bruno Di Stefano retweeted
Check out our new preprint: (biorxiv.org/content/10.64898…) that highlights estrogen signaling in trophoblast development. Our data suggest that increased dosage of NRIP1 impairs this pathway, contributing to placental defects in Down syndrome. Great work by @deirdre_logsdon & team!
Bruno Di Stefano retweeted
I don’t tweet much so I’ll keep this simple
We are looking to recruit 1-2 new postdoctoral fellows, to study human hematopoietic development, from both basic and translational perspectives, using iPSCs.
Please reach out via email for more details if interested!
My lab @bcmhouston is hiring a postdoctoral fellow to study hematopoiesis and leukemia using innovative degron mouse models, RNA recording technologies, and functional genomics approaches.
If you are interested, please see the position details below:
Bruno Di Stefano retweeted
Interesting symposium on ribosome heterogeneity sponsored by Science. Registration is free: us02web.zoom.us/webinar/regi…
Bruno Di Stefano retweeted
Very excited to share our Molecular Cell @MolecularCell on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! cell.com/molecular-cell/full…
Bruno Di Stefano retweeted
Dr. Bruno Di Stefano (@DiStefano_Lab), Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!
Bruno Di Stefano retweeted
Sure you can profile RNA but does that actually tell you what a cell will do? Or what it was doing?
Here's a fun reflection led by @kaseyslove on the recent work from the lab @DiStefano_Lab. Their excellent study shows that microRNAs sequester mRNA from the preceding cell fate in P-bodies. Food for thought on how much we can (and cannot) see in profiles of RNA and how we might harness natural sequestration pathways to improve cell fate programming
Bruno Di Stefano retweeted
Modulating RNA condensates to control cell fate #NBTNV go.nature.com/4iyZmGv
Bruno Di Stefano retweeted
Elevate your career in stem cell science! Become an ISSCR member to enjoy exclusive benefits: complimentary webinars, preferred rates for events including ISSCR 2026, publishing benefits, & access to an international network. Join today 👉 bit.ly/4eOL2H1 @DiStefano_Lab
Bruno Di Stefano retweeted
Excited to share our new study uncovering and overcoming the molecular drivers of interspecies PSC competition to improve human chimerism in animals. Big congratulations to first authors Yingying, Hai-xian, and Saku, and to our collaborators! cell.com/cell/fulltext/S0092…
Bruno Di Stefano retweeted
Meet Early Career Editor Bruno Di Stefano (@DiStefano_Lab) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
Bruno Di Stefano retweeted
This is one of the most interesting papers that I have ever read!
1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s41587-0…
7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.
8/ Huge thanks to our editor and reviewers for invaluable feedback, and to our funders NIGMS, @theNCI, @NIAIDNews, @ASH_Hematology, @WorldwideCancer, @BePositiveFdn, @WebbWaringAwrds, NICHD, and @CPRITTexas for supporting this work!