Led by Michael Brehm, PhD, our lab uses novel humanized mouse models to investigate type 1 diabetes & cancer in vivo @umasschan @umassdiabetes
UMass Chan Diabetes Center
Joined May 2023
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Brehm_Lab_UMassChan retweeted
Truly phenomenal meeting. Great talks and panels. Hard questions. Exciting new ideas and directions. Thank you to the Levine-Riggs Diabetes Research Symposium for bringing us all together and helping drive progress in the field! #immunologymatters #changingwhatspossible #endt1d
Brehm_Lab_UMassChan retweeted
Delighted to speak at the Rachmiel Levine-Arthur Riggs Diabetes Research Symposium! Bracing myself for an avalanche of knowledge! #immunologymatters #endt1d
Brehm_Lab_UMassChan retweeted
I got my first R01! $3M dollars. 5 y. NIAID. Huge thank you to my co-investigators Holger Russ & Michael Brehm, my lab members & the foundations who believed in me, the Medical University of South Carolina & Hollings Cancer Center for an outstanding environment.#immunologymatters
Brehm_Lab_UMassChan retweeted
The Food and Drug Administration is a critical partner in accelerating cures and therapies for type 1 diabetes. The nominee to run FDA knows first-hand how important that is. Dr. Heidi Overton, nominee to be the next FDA Commissioner, has shared with us that she lives with type 1 diabetes.
Brehm_Lab_UMassChan retweeted
Incredibly proud of @leeanadenise1, a new K99/R00 recipient, for leading this work. JCI - Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes jci.org/articles/view/196445
Brehm_Lab_UMassChan retweeted
Happy to share a recent publication with our collaborators at Wilmer on crystalline drug delivery to the eye to treat wet age-related macular degeneration @JCRnEDITORS!
sciencedirect.com/science/ar…
& Recent press release:
bme.jhu.edu/news-events/news…
@JHUBME @TTECJHU @HopkinsMedicine
Brehm_Lab_UMassChan retweeted
Two interdisciplinary teams of UMass Chan faculty were awarded $45,000 each from the Dan and Diane Riccio Fund for Neuroscience to support their groundbreaking research in neuroscience: direc.to/o_H4
#AdvancingTogether #neuroscience @summerbthyme @UMassChanGiving @UMass
ALT Summer Thyme, PhD, and Brian Kelch, PhD
ALT Stephanie Puig, PhD, and Andrea Reboldi, PhD
Brehm_Lab_UMassChan retweeted
Can mRNA vaccination induce tolerance rather than immunity? 🧬 Autoantigen mRNA-LNPs reduced disease in mouse models of MS and type 1 diabetes. A modular platform—but durability and safety remain preclinical.
doi.org/10.1002/advs.76382
#Autoimmunity #Tregs
Brehm_Lab_UMassChan retweeted
MD/PhD student Melanie Barbini has received an @NIH award that could have implications for multiple sclerosis and Alzheimer’s patients. Read about why she credits mentors Dorothy Schafer, PhD, and Chancellor David McManus: direc.to/oBqX #StudentSpotlight @UMassMDPhD
Brehm_Lab_UMassChan retweeted
Based on a new NOA recieved this month, we are looking for a postdoctoral fellow with solid foundation of molecular skills, creativity, and translational passion to help us develop innovative CARs for targeting discrete subsets of T cells. DM or email me if interested
Brehm_Lab_UMassChan retweeted
We are recruiting a postdoc to work on an NIH funded project to determine the role of aging and oncogene-induced stromal senescence on prostate cancer initiation and therapy resistance. See job posting and recent publication below.
ummsjobs.com/job/11591/
aacrjournals.org/cancerdisco…
Brehm_Lab_UMassChan retweeted
MISSION POSSIBLE. Overjoyed to speak at the Breakthrough T1D 2026 South Carolina Gala!
#immunologymatters #maketype1typenone
m.youtube.com/watch?v=Tc7-0a…
Brehm_Lab_UMassChan retweeted
Raymond M. Welsh, Jr. (1945–2024)—a life in viral immunology, immune regulation, and scientific mentorship @JVirology @randyb_IUSM @VargaLab @BrehmLab @CloudyMediaBlog
doi.org/10.1128/jvi.00663-26
Brehm_Lab_UMassChan retweeted
New commentary Immune-competent new approach methodologies for a hybrid future (w/ animal models) just out @NatImmunol! Congrats to co-1st authors @VanceSoares & @victorquiroz68! And co-corresponding authors @MTrapecar & @deokkim1!
nature.com/articles/s41590-0…
@JHUBME @TTECJHU
Brehm_Lab_UMassChan retweeted
Congratulations to Dr. Marcus Ruscetti of @UMassChan Medical School on receiving the prestigious 2026 Pershing Square Sohn Cancer Prize — which recognizes scientists who are accelerating cures for cancer through innovative research. #CancerResearch
🔗 brnw.ch/21x2wcV
Brehm_Lab_UMassChan retweeted
New @NIH support for #diabetes-relevant #research @UMassChan: Louis Messina, MD, has received a 5-year, $3 million grant to study how aging changes immune cells and impairs wound healing. More here: umassmed.edu/news/articles/2…
UMass Chan Medical School +1 – at Worcester, MA
Brehm_Lab_UMassChan retweeted
Summer Internship Opportunity @TheBartonCenter (Jul 5–Aug 10) offering hands-on experience in glucose monitoring, insulin management, CGMs/pumps & education while mentoring kids with #T1D. Housing/meals & academic credit. Apply/share! Other openings too! [email protected] – at Worcester, MA
Brehm_Lab_UMassChan retweeted
From immigrating alone at 15 to pursuing a career in medicine - Check out the latest in our "Meet the Researcher" series. Tai Le is a post-bacc in my laboratory helping to develop a cure for diabetes
In our "Meet the Researcher" series, learn about Tai Le of the Millman Lab and what inspires his passion for stem cell engineering and medicine—and how it’s shaping his path forward: bit.ly/47IAI2e. @JeffreyRMillman
Brehm_Lab_UMassChan retweeted
Great teamwork by @UFBME and @ufdiabetes researchers, along with the teams @Immunocore and @DiabetesnPOD.
Brehm_Lab_UMassChan retweeted
Can cancer cells be roped into producing cytokines that can direct an immunotherapy? We are excited to share our study in @MCT_AACR led by @GriffinIKane with @mdgetsaphd and others @UMassBME @UMassChan @UMassCancerCtr aacrjournals.org/mct/article…
