@Boyer_TL

Post-Doctoral Fellow @Rush University Medical Center | Previously @UVABME, PhD @Northeastern Bioengineering

 Boston, MA
Joined November 2013
  • Tweets159
  • Following219
  • Followers132
5Media
Excited to share my first first-author paper! A big thank you to my wonderful co-authors. Check it out 50 days free:
Bajpayee Lab@BajpayeeLab22 Apr 2025
Calling all Disease-Modifying OA Drugs‼️ We are excited to share new work led by @Boyer_TL now published in @OACJournal on evaluating Cationic Peptide Carriers for drug delivery of DMOADs in an animal model of post-traumatic osteoarthritis. Free Access: authors.elsevier.com/c/1kyZk…
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Therapeutics given to the knee joint are rapidly cleared. In this work, Boyer et al. engineered a cationic Interleukin-1 Receptor Antagonist (catIL-1RA) to target anionic cartilage and form drug depots within the joint. Read more: oarsijournal.com/article/S10…

Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and...

Even after intra-articular injections, therapeutics to treat osteoarthritis are limited by rapid drug clearance given their poor joint retention. To address this, we engineered a cationic Interleuk...

oarsijournal.com
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Tim Boyer retweeted
Bajpayee Lab@BajpayeeLabJan 19
We are excited to share our newest work by Dr. Boyer @Boyer_TL et al on engineered cationic Interleukin-1 receptor antagonist for OA treatment!
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We are thrilled to share our latest work titled "Spatial charge-hydrophobicity configuration modulates cationic peptide transport in cartilage," published in @BiophysJ Free access: authors.elsevier.com/c/1lsw9…
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Congratulations to @FortinAiyana for her paper in @ActaBio describing extended joint residence time and chondrocyte internalization of C’Dot nanoparticles for #osteoarthritis therapy. #NSFfunded @GroupWiesner @CornellBME  @CornellMSE
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New content online: Targeting osteoarthritis where it hurts: the osteochondral junction bit.ly/42I4dhg

Targeting osteoarthritis where it hurts: the osteochondral junction

Nature Reviews Rheumatology - In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain....

nature.com
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We are thrilled to share our latest work on surface-engineered exosomes for sustained interleukin-1 receptor antagonist (IL-1RA) delivery to cartilage via electrostatic interactions, now published in Osteoarthritis and Cartilage! @OACJournal Check it out! sciencedirect.com/science/ar…
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🚀 New preprint from the Shefelbine Lab! doi.org/10.1101/2025.02.05.6… 🦴Yoda2 + tibia loading combination enhance mechanoadaptation in 22-month-old mouse bones. Preliminary in vivo calcium imaging suggests Yoda2 reaches osteocytes in old mouse bones @ORS2025 2/8, 4:15pm North 221
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I am excited to share my recent PhD research with a podium presentation on Saturday and chat with prospective Post-Doc Advisors! Come chat with me at my Future Post-Doc Poster! @ORSsociety #ORS2025. @BajpayeeLab
Orthopaedic Research Society@ORSsociety4 Feb 2025
Seeking Faculty and Postdocs? Join us for the Future Faculty Poster Session or the Postdoctoral Fellow Match Poster Session on Sunday, February 9 at #ORS2025 to connect with the future of #musculoskeletal research. 🔗 Request applicant PDFs now: bit.ly/3VpBTxt
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Thank you to co-chairs @AmbikaBajpayee @ANKoppes, planning committee, and students for Northeast @SFBiomaterials Symposium @NUBioE1. Bajpayee lab members were busy! (1/n)
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Excited to share our recently published work on synthesizing charge-reversed cationic exosomes which demonstrates superior transport, retention, and mRNA delivery to the deep layers of cartilage tissue. Open Access #SmallMethods. rb.gy/i1bbxm Cred @ChenzhenZhang et al!
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Excited to share our new method preprint, WISH-BONE, to label osteocyte mRNA and protein in 3D mouse bone, presented at #ORS2024. Collaboration between ShefelbineLab, @monaghan_lab, and @LifeCanvasTech. Stay tuned for videos! biorxiv.org/content/10.1101/… @ORSsociety, @NUBioE1
Whole mount HCR FISH in mouse tibia. A) 3D view of a mouse tibia midshaft labeled for Sost. B) Cross-sectional 2D view of the 3D mouse tibia midshaft showing Sost expression in the cortical bone. C) Zoom on the cortical bone showing expression of Sost (arrow with circle) and Dmp1 (plain arrow) through the cortical thickness. Osteocytes expressing both Dmp1 and Sost appears white (double-headed arrow). D) Zoom on the cortical bone showing colocalization of Sost signal and nuclear staining (plain arrow). E) Negative control. The sample was incubated with fluorescent DNA hairpins without prior incubation with probes. White arrows show autofluorescence of a blood vessel and some remaining part of bone marrow. Images were acquired via lightsheet microscopy. Dotted lines highlight the cortical bone.

ALT Whole mount HCR FISH in mouse tibia. A) 3D view of a mouse tibia midshaft labeled for Sost. B) Cross-sectional 2D view of the 3D mouse tibia midshaft showing Sost expression in the cortical bone. C) Zoom on the cortical bone showing expression of Sost (arrow with circle) and Dmp1 (plain arrow) through the cortical thickness. Osteocytes expressing both Dmp1 and Sost appears white (double-headed arrow). D) Zoom on the cortical bone showing colocalization of Sost signal and nuclear staining (plain arrow). E) Negative control. The sample was incubated with fluorescent DNA hairpins without prior incubation with probes. White arrows show autofluorescence of a blood vessel and some remaining part of bone marrow. Images were acquired via lightsheet microscopy. Dotted lines highlight the cortical bone.

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Great talks by Helna and Tim on #ElectrostaticDrugDelivery! Thank you @ORSsociety for hosting us! Now excited to continue the work! @NUBioE1 @AmbikaBajpayee
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We are super excited to head back to #ORS2024 this year! Come stop by our posters and talks on #ElectrostaticDrugDelivery! @ORSsociety @OrsSpineSection @NUBioE1
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Happy to share that our recent work was selected by @BioMaterSci to be featured as cover art! Here we develop mucus penetrating milk exosomes for oral gene delivery! Link: xlink.rsc.org/?DOI=D3BM01089…
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We are delighted to share our new publication on oral delivery using surface-modified milk exosomes for  siRNA delivery to the GI tract with ionic interactions. @BioMaterSci. Link: doi.org/10.1039/D3BM01089A Congrats to @Henry28338841 & @ChenzhenZhang  who spearheaded this project!
Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

ALT Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

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Tanvi’s award-winning research using a new therapeutic approach to combat osteoarthritis was selected by @SFBiomaterials for an Online Talk this Wednesday 12/6 at 12PM. Join Virtually here: bit.ly/3Fy3IuU (Free Registration)!
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Check out our new exciting work, showing we can deliver therapeutics into cartilage with simple and safe positively-charged peptides and proteins!
Osteoarthritis and Cartilage Journals@OACJournal14 Jun 2023
IL-1Ra when conjugated to positively charged drug delivery carriers can effectively suppress #osteoarthritis associated catabolism with a one-time dose @smehta93 @BME_Tim @AmbikaBajpayee bit.ly/3N63f6u
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Last week we got to congratulate Dr. Chenzhen Zhang on completing his Ph.D. @ChenzhenZhang has built the foundation for multiple new research directions in our lab and has been an invaluable asset to 7 new Ph.D. students!
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Curious about CT imaging for cartilage? Check out our new publication in @acsnano exploring cationic cartilage-targeting contrast agents used in low-doses! pubs.acs.org/doi/10.1021/acs… @ChenzhenZhang @vedadghavami @htf331
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