BioPrime retweeted
Just completed a drug discovery screening on @BioPrimeAI! Target: CDK4/6 - Breast Cancer | Best binding energy: -13.46 kcal/mol | Advancing science with decentralized compute. bioprime.one/results/JOB-0ff…
We are proud to announce TopoGrammar, a platform designed to illuminate the "dark matter" of the genome. While traditional pipelines focus on dosage, #TopoGrammar focuses on topology.
Introducing TopoGrammar: Cracking the "VUS" Code with 3D Genomics & Blockchain
68% of identified ##genomic variants are currently classified as "Variants of Uncertain Significance" (#VUS). For patients, this means a #diagnostic dead end.
The Problem: Conventional sequencing misses "balanced" structural variants, inversions and translocations that don't change gene dosage but do wreck the genome's 3D regulatory architecture.
The Solution: #TopoGrammar treats chromatin organization as a structured language. By modeling enhancers and promoters as "grammatical sentences," we identify disruptions that others miss.
The Tech:🧬 PINNs: Physics-informed neural networks for high-fidelity 3D reconstruction. 🎯
- CTCF-Gating: 91% boundary detection accuracy (outperforming HiCCUPS). ⛓️ #Blockchain
- Attestation: Every result is hashed to the #BSV blockchain for immutable, @US_FDA-compliant verification without exposing PHI.
The Results:• 68% VUS reclassification rate. • 93% pathogenic accuracy. • Seamless integration with @BioPrimeAI v4.0 for genome-to-drug workflows.
Stop guessing on VUS. Start decoding the #3Dgenome.
🔗 Try the Live Demo: huggingface.co/spaces/GotTha…
@SmartLedgerTech @bioprimeai @Sdot2121 @Codenlighten1 @jalexanderm @grok
#Genomics #PrecisionMedicine #AI #Biotech
BioPrime's sponsor community is making history. @jalexanderm leading breast #cancer #research. @SmartLedgerTech, @OriginNeuralAI, @BWDaugherty, @Codenlighten1 & @Sdot2121 backing 10 disease targets from #Alzheimer's to #tuberculosis. 6.3M compounds screened. DeSCI ♥️
Drug discovery demands immutable #data provenance.
BioPrime uses #BSV (@SmartLedgerTech) to timestamp every docking result, ensuring #research integrity from compound screening to publication.
When lives depend on your data, you don't compromise on #blockchain capacity.
Yes 🙌
This is amazing ❤️ and needs more awareness! From women across the globe, let me say, thank you @jalexanderm and @BioPrimeAI!
What an amazing opportunity!
⚡️ Enhancements:
• Grid-based sampling
• Adaptive parameters
• Multi-start optimization
Goal: Match Vina's 70% success rate on blockchain rails.
This is the future of #DeSci 🧬🔗
#Biotech #DrugDiscovery #Web3
🔬 BioPrime Engine Deep Dive
We're live-benchmarking our improved docking algorithms:
📈 Results so far:
• 16% better RMSD (closer to crystal structure)
• Testing: HIV protease, kinases, GPCRs
• 200 poses × 100 GD steps × 30 ILS iterations
Metabolic targeting is why BioPrime screens multiple cancer pathways.
Active campaigns:
• Melanoma (BRAF V600E)
• Breast cancer (CDK4/6)
• HIV-1 Protease
Targeting metabolism requires compounds that work. Molecular docking accelerates discovery.
Exactly right. Every BioPrime docking result → BSV blockchain → immutable proof.
No lab notebooks. No trusted intermediaries. Just cryptographic hashes + timestamps.
Blockchain as public notary for computational science.
Same optimization engine powering BioPrime's 10,000x drug discovery speedup.
OriginNode proves it in blockchain.
BioPrime proves it in molecular docking.
Production-validated.
42.9% improvement under adversarial conditions speaks louder than any whitepaper. 🧬
Blockchain node that gets BETTER under attack?
Just verified OriginNode:
- +42.9% improvement under stress
- 3.85s to complete
- Immutable BSV proof
whatsonchain.com/tx/57b1cea8…
The Daugherty Engine is real. #BSV
🎁 Reminder: Every signup gets $5 free credit That's 1 million compounds screened. For free. No payment required. Students, small labs, researchers anywhere—just sign up and run your campaign.
Democratizing drug discovery, one free million at a time.
Bioprime.one