@Bio2Byte

We investigate how the dynamics, conformational states and available experimental data of proteins relates to their amino acid sequence. https://xitter.cf/t.co/P91Z79De6S

 Belgium
Joined April 2020
  • Tweets32
  • Following49
  • Followers47
2Media
Bio2byte is excited to welcome our new master's students! Golnar Chapnevis, Arathy Uday, Ayda Azadegan, Melika Seirani, Tutku Ekin Bayrı, and Nigel Wens. Wishing you all the best as you embark on your exciting thesis projects. Good luck 👏🏽
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Our recent work on predicting the #cancer driver #mutations combining the evolutionary information and protein language model (#plm) is out in Biorxiv. biorxiv.org/content/10.1101/…

Combining evolution and protein language models for an interpretable cancer driver mutation...

The mutations driving cancer are being increasingly exposed through tumor-specific genomic data. However, differentiating between cancer-causing driver mutations and random passenger mutations...

biorxiv.org
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Spatial proteomics in the context of #protein #modifications, #structure #function and #dynamics. Visit @Pathmanaban_'s poster this evening at the #BSPREUPA2023 Congress.
Pathmanaban Ramasamy@Pathmanaban_18 Jul 2023
Working in #spatial #proteomics? Like to know how the post-translational modifications (#ptms) of #proteins varies between and within #tissue types? Wondering how does that compare with the protein #behavior? Find the answers at my poster (# 152) in #BSPREUPA2023 conference.
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At #ASMS2023 and interested in Post-translational modifications of proteins? Feel free to join me this afternoon where I will be talking about my recent work on #tissue specific #PTM maps in #human #proteome. Especially on tissue specific protein #phosphorylation.
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Registrations are open! Check the link below. #Challenges and #opportunities in #AI based research in #hospitals.
icity.brussels@icity_brussels21 Sep 2022
🔥Join us on October 6th🆓Register now!👉insightz.io/content/275/icit… 🖥 Wim Vranken will present the TumorScope project, which strives to overcome the amount, complexity, & protection of health-related data & to stimulate innovation in the #AI-driven interpretation of #patientdata.
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At Today's poster session @ECCBinfo David will present his work on large scale conformational dataset, that links the #peptide #sequence and #phosphorylations to changes in backbone conformations and #dynamics. Poster number: P189-T Track: Proteins #ECCB2022
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Hello #ECCB2022. Don't forget to check Sophie's poster this evening. Sophie will present her poster on "Using #AlphaFold2-generated #structural information to improve detection of #evolutionary adaptations in #proteins". Poster number: P150-T Track: Genomes @ECCBinfo
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At #ECCB2022? Check @GavaldaGarcia's poster P181-M. Jose from our group will present ConforMine, a predictor of protein #Conformational Variability from amino acid #sequence. His poster features an explanation of both the #biophysical basis and the estimator for this metric.
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Hope everyone is having an amazing day at @ECCBinfo #ECCB2022. Here is our @Bio2Byte delegation with interesting topics. Don't forget to pass by our poster stands. Looking forward to meeting you.
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Hello #ECCB2022, In today's Session#1 under #ELIXIR @ELIXIREurope track, Wim Vranken will be talking about the resources and synergies between three ELIXIR communities; #proteomics, Intrinsically disordered proteins(#IDPs) and 3D-#Bioinfo at Auditorium Anna Tramontano at 10 AM.
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#Scop3P an @ELIXIRnodeBE service developed by @Pathmanaban_ in collaboration with @compomics, links human phosphorylation sites with protein structures and biophysical characteristics. Check the link below and give it a try! Feedbacks are welcome.
ELIXIR Belgium@ELIXIRnodeBE12 Sep 2022
📢Scop3P provides a unique and powerful resource for researchers to explore and understand the impact of phospho-sites on human protein structure and function. ✅Why not try it out? bit.ly/3Ca31HE 🔗 #bioinformatics #openscience #opensource #DataScience @ResearchSoft
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Another interesting perspective on highly dynamic and/or structurally ambiguous behavior of protein regions and the challenges involved in describing these ambiguous regions from the biophysical aspects.
Tamas Lazar@LazTamas9 Aug 2022
We're glad to share our latest publication on the challenges in describing the conformation and dynamics of proteins with ambiguous behavior, authored among others by @JoelRockM @LazTamas @GavaldaGarcia @KTzavella @Pathmanaban_ @Grau_Isel and @Wim_Vranken: frontiersin.org/articles/10.…

Frontiers | Challenges in describing the conformation and dynamics of proteins with ambiguous...

Traditionally, our understanding of how proteins operate and how evolution shapes them is based on two main data sources: the overall protein fold and the pr...

frontiersin.org
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RNAct conference tailoring RNA binding proteins and RNA targeting. September 14 and 15 in Valencia, Spain. Register here: rnact.eu/FinalConference/#re…
Wim Vranken@wim_vranken9 Aug 2022
Protein-RNA interactions are essential - the RNAct MSCA-ITN conference (14-15/09/22, Valencia, Spain), focusses on how proteins bind RNA, and how we can tailor RNA binding proteins for synthetic biology and biosensor development - register at rnact.eu/FinalConference/! @eu_rnact
Using the wealth of available phospho-proteomics #MassSpec data, the @compomics & @Bio2Byte labs demonstrate the advantage of data reprocessing for a more reliable & comprehensive view of proteome-wide P-sites. pubs.acs.org/doi/10.1021/acs…
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Our recent work shows an interesting view on the reliability of #protein #phosphorylation sites from other gold standard resources when compared to re-processed data from #Scop3p. Also shows their possible impact on #structures, functional #domains and #biophysical properties.
Pathmanaban Ramasamy@Pathmanaban_9 Jul 2022
Are you working on #protein #phosphorylations (#PTMs)? Ever wondered where these modifications are occurring on protein #structures and how that would affect their biophysical properties, structural transitions and #mutations? Then this is for you! pubs.acs.org/doi/10.1021/acs…

Panoramic Perspective on Human Phosphosites

Abstract. Protein phosphorylation is the most common reversible post-translational modification of proteins and is key in the regulation of many cellular p

pubs.acs.org
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Workshop on AI based solutions for health care. Together with @imec_smit. More details in the thread.
imec-smit, VUB@imec_smit18 May 2022
What are challenges around the #development and #implementation of clinical #AI solutions? 🏥 SMIT researcher Lawrence Van den Bogaert will present on #AI for #healthcare on the 15th of June. Registration link : bit.ly/TumorScope
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Excellent work from one of our PhD student @Pathmanaban_ showing how re-processing of public #proteomics data can help identify reliable P-sites and the possible dynamics involved in protein phosphorylation.
Pathmanaban Ramasamy@Pathmanaban_10 Mar 2022
We present a large scale integrated approach to understand the #human phosphosites and phosphoproteins by placing them in a variety of possible contexts such as #sequence, #structure, #disorderedness and #biophysical properties. biorxiv.org/content/10.1101/…

A panoramic perspective on human phosphosites

Protein phosphorylation is the most common post-translational reversible modification of proteins and is key in the regulation of many cellular processes. Due to this importance, phosphorylation is...

biorxiv.org
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This will change the history of structural biology research. Great effort from @DeepMind @uniprot @PDBeurope.
UniProt@uniprot22 Jul 2021
A historic moment in the world of molecular structural research. #AlphaFold structure predictions for 22 species made freely available by @deepmind, access through @uniprot and @PDBeurope. Learn more at insideuniprot.blogspot.com/
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!!! We are hiring !!! Two open positions (PhD and a software developer) available immediately to work on the relation between post translational modifications (PTMs), protein dynamics and cellular localization of proteins. Check the link for more: bio2byte.be/opportunities
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The 2nd issue of the #RNAct Newsletter is online! Read it online at rnact.eu/newsletter/ and make sure to subscribe to receive future updates. We hope you enjoy the reading!
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