Postdoc @RockefellerUniv l O’Donnell Lab l DNA replication, repair, & single-molecule biophysics

Manhattan, NY
Joined February 2020
Gabriella Chua retweeted
TPCB’s Gabriella Chua, PhD and colleagues in the Liu, O’Donnell, & Zhao labs at Rockefeller and MSK found that RFC, the clamp-loader protein that installs PCNA onto DNA, doesn’t detach and move on as believed—it rides along with PCNA during DNA replication bit.ly/TPCBnews
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Gabriella Chua retweeted
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature nature.com/articles/s41586-0…
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One of my favorite studies to come out of the Liu and Alushin labs. Check it out 🚖🚙
Have you ever wondered what a car crash would look like at the nanoscale? Check out our latest preprint led by soon-to-be Dr. John Watters! @JWatts421 @Alushin_Lab @RockefellerUniv 🧬🚗
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Huge congratulations to the recipients of the 2026 Weintraub Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. fredhutch.org/en/news/releas…
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Gabriella Chua retweeted
Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab. biorxiv.org/content/10.64898…
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Gabriella Chua retweeted
Nucleosome spacing regulates linker methylation by DNMT3A2/3B3 dlvr.it/TRL46G
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A study in @CellCellPress from Shixin Liu (@InLiuOfBulkExps) and Michael O’Donnell finds that a protein once thought to simply help load a factor necessary for the copying of DNA actually plays a key role in ensuring fast and reliable replication: bit.ly/4qOodK1
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Check out our paper @CellCellPress where we visualized the interplay between two key DNA replication factors PCNA & RFC and found an unexpected non-catalytic role of RFC in stabilizing PCNA’s interaction with DNA polymerase and enabling efficient synthesis cell.com/cell/fulltext/S0092…
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Our work on single-molecule visualization of mammalian transcription elongation is online @NatureSMB today! Check out the open-access paper rdcu.be/eR257 to see how Pol II acts as a multi-speed machine🚗We are thankful for our collaborators @RockefellerUniv @FudanUniv🙏
New online! Kinetic control of mammalian transcription elongation bit.ly/4ipj2wp
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Vostal et al @KapoorLab_RU @RockefellerUniv report two structures of complexes formed by VCP, an unfoldase, & VCPIP1, a deubiquitinase, & suggest that VCPIP1 is poised to cleave #ubiquitin from protein substrates that translocate through VCP’s central pore hubs.la/Q03bV3G00
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Scientists in the @Alushin_Lab have figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for metastasis. #RockefellerScience bit.ly/3PKErmA
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Very happy to share our new review in @MolecularCell covering nucleic acid recognition and effector mechanisms for various prokaryotic immune systems! Was a great experience creating this with @MarraffiniLab! cell.com/molecular-cell/full…
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Using the @LUMICKS C-Trap, the lab of @InLiuOfBulkExps provided unprecedented, real-time insights into the binding behavior of MeCP2, a protein linked to Rett syndrome, across methylated and unmethylated DNA and nucleosomes. lumicks.com/revealing-mecp2-…
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Really honored to receive this award🤍😊 I was initially drawn to @TPCB_NYC for my graduate studies because the students were not just scientists; they were also leaders, advocates, & teachers fiercely focused on both science and society. Grateful!
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Gabriella Chua retweeted
Congratulations to Christian Baca @ChristianF_Baca in the Marraffini lab on being recognized by the Max Birnstiel Foundation and Research Institute of Molecular Pathology @IMPvienna with an Honourable Mention for the 2024 International Birnstiel Awards! linkedin.com/posts/tpcb_chri…
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Want to introduce kids to the biophysics of DNA? Make candy models!! 🍬🍭🧬 Not only do they learn about its chemical sequence but also its physical features- bendability, stretch & twist- that are highly relevant to biology. Congrats to @rockedu_ on another 🔥 Science Saturday!
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