@Alushin_Lab

Interested in cryoEM, cytoskeleton, and mechanosensation at the molecular level.

 New York, USA
Joined October 2017
  • Tweets676
  • Following665
  • Followers1.5K
98Media
Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery? Join our amazing faculty at the @weillinstitute at @Cornell University in Ithaca, New York. academicjobsonline.org/ajo/j… Apply by Nov. 15! Please share!
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We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Please share! apply.interfolio.com/191981
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UC Berkeley MCB@berkeleyMCB
Aug 14
MCB is hiring Assistant Professors across 3 divisions!: 🧪 BBS: aprecruit.berkeley.edu/JPF05… 🧬GGED: aprecruit.berkeley.edu/JPF05… 🦠IMM: aprecruit.berkeley.edu/JPF05… 🗓️ Application Deadline: October 19, 2026 🔗 Click the links or scan the QR codes to learn more and apply
MCB is hiring 3 Assistant Professor positions across 3 divisions: Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM) BBS application link: https://aprecruit.berkeley.edu/JPF05483 GGED application link: https://aprecruit.berkeley.edu/JPF05481 IMM application link: https://aprecruit.berkeley.edu/JPF05486

ALT MCB is hiring 3 Assistant Professor positions across 3 divisions: Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM) BBS application link: https://aprecruit.berkeley.edu/JPF05483 GGED application link: https://aprecruit.berkeley.edu/JPF05481 IMM application link: https://aprecruit.berkeley.edu/JPF05486

Assistant Professor of Immunology and Molecular Medicine. IMM application link: https://aprecruit.berkeley.edu/JPF05486

ALT Assistant Professor of Immunology and Molecular Medicine. IMM application link: https://aprecruit.berkeley.edu/JPF05486

Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483

ALT Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483

Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481

ALT Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481

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Alushin_Lab retweeted
Sue Biggins@SueBiggins
Aug 17
Faculty opening in Basic Sciences @fredhutch! Egalitarian and supportive environment:
Fred Hutch Cancer Center@fredhutch
Aug 16
🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @HutchBasicSci. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640
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Polly Fordyce@fordycelab
Jun 3
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
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Martin Pacesa@MartinPacesa
May 30
Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!! biorxiv.org/content/10.64898…
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How do cells convert mechanical information into a molecular process? The @Alushin_Lab has captured the first snapshot of a mechanical signaling complex in action, findings in @Nature that have implications for disorders related to myosin dysfunction. 🔗: bit.ly/41Kshjw
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Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature nature.com/articles/s41586-0…

Myosin forces remodel F-actin for mechanosensitive protein recognition

Nature - Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and...

nature.com
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After additional work, we believe that it is exclusively axial compression which produces supercoils. Compression can occur on a subset of filament segments even under conditions which globally produce tension, due to the stochastic mechanochemical cycles of uncoupled motors.
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We thank the reviewers for their insightful comments which clarified many additional aspects of the paper beyond this key point. Congrats to co-first authors Ayala Carl, Matt Reynolds @mattabolic_rate , and Xiaoyu Sun @XiaoyuSun_LIM !
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Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab. biorxiv.org/content/10.64898…
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Cytoskeleton enthusiasts: join us for the Cytoskeletal Motors GRC, July 12-17, 2026, in Portland Maine. Abstracts submitted by April 5 will be considered for short talks. Please apply! bit.ly/4cWxvzj
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Scientists in the @Alushin_Lab figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview 🔗: bit.ly/3PKErmA
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DNA nanodevice for analysis of force-activated protein extension and interactions. A tension-modulated #DNAorigami #nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins. nature.com/articles/s41565-0…
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🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici rdcu.be/eUPPl
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How do cells move, divide, and sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer and birth defects follow. @Alushin_Lab at @RockefellerUniv has developed new tools to probe this tiny, dynamic cell scaffolding. rockefeller.edu/news/38446-h…
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nature.com/articles/s41567-0… The latest research article from the Ti Lab is finally out today in Nature Physics.

Tubulin isotypes of C. elegans harness the mechanosensitivity of the lattice for microtubule...

Nature Physics - Proteins interact with both the exterior and interior of microtubules. Here the relationship between microtubule building blocks and the accessibility of the microtubule interior...

nature.com
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Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty. Learn more below: rockefeller.edu/facultysearc…

Faculty recruitment - Our Scientists

rockefeller.edu
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Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab wsj.com/politics/policy/trum… Trump Administration Puts New Chokehold on Billions in Health-Research

Trump Administration Scraps Effort to Pause Health-Research Funding

The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

wsj.com
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