@BenHobs3

Psychiatry resident @CUAnschutz 🏔️ | 🧠 🧬 🔬 | MD, PhD @columbia 🌃

 New York, NY
Joined February 2019
  • Tweets352
  • Following270
  • Followers215
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Beyond thrilled to have matched into the Research Track Psychiatry residency @CUAnschutz!! Huge thanks to @psimslab @david_sulzer and so many others for an amazing 8 years in NYC... I can't wait to be back home in CO and get to work @CU_Psychiatry! 🏔️🌄 #Match2023 #psychmatch
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I’m on the faculty market this fall! NIH K99/R00 awardee using birdsong to study how brains learn complex skills across molecules, synapses, circuits, behavior & computation. Know a faculty search where I might fit? Send it my way + share! drewschreiner.github.io/ #neuroscience

Drew Schreiner, Ph.D. | Neuroscience of Learning

I use birdsong to understand how the brain learns complex skills across molecules, synapses, circuits, behavior, and computation. On the 2026–27 faculty job market.

drewschreiner.github.io
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Ben Hobson retweeted
AJHG@AJHGNews26 Feb 2025
📣 New today! 📄Genome-wide prediction of dominant and recessive neurodevelopmental disorder-associated genes 🧑‍🤝‍🧑@RyanDhindsa @awzoghbi & colleagues cell.com/ajhg/abstract/S0002…
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200 retweets and I’ll do the 200/400 double at worlds…. I’ll beat Noah and Vernon 😂🤝🏾… Grant also gotta see me in the 110 too.. I’ll take the stripes off his lil vest
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Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: huttenhainlab.com By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospe… #TeamMassSpec

Huttenhain Lab | Home

The Huttenhain Lab at Stanford University studies cellular signaling networks to uncover how cells decode extracellular cues into dynamic physiologic responses.

huttenhainlab.com
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Electrical synapse molecular diversity revealed by proximity-based proteomic discovery biorxiv.org/cgi/content/shor… #biorxiv_neursci
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And we are LIVE! @sthom003 and I finally have our lab website. Check out the Laboratory of Translational Psychiatry and all the great work by our team. 🧠Research, Training and Community. Thanks to @stellatecomms for their ingenuity on this. balethompsonltp.org

The Laboratory of Translational Psychiatry at CU Anschutz

The University of Colorado’s Laboratory of Translational Psychiatry, including the Bale and Thompson Labs, studies the causes of neuropsychiatric disease.

balethompsonltp.org
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Thrilled to see our paper "A Proximity Proteomics Pipeline with Improved Reproducibility and Throughput" published! It describes the automated enrichment of biotinylated proteins in a 96-well plate format for spatial proteomics and protein interactions. embopress.org/doi/full/10.10…
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Beautiful work… This study is so exciting! Among many exciting findings, the authors found ultrastructural evidence for localization of TRiC/CCT in DA axons and the lack of axonal ribosomes in DA neurons, corroborating in vivo results from my graduate studies
Simon Erlendsson@SimonErlendsson16 Apr 2024
Extremely happy to share our preprint on the Ultrastructural Dynamics of Dopaminergic Presynaptic Release Sites revealed by CryoCLEM. A pleasure working with good friends and colleagues on this! @LycasEats @DustinMorado @UlrikGether @BriggsGroup biorxiv.org/content/10.1101/…

Ultrastructural Dynamics of Dopaminergic Presynaptic Release Sites revealed by Cryo-correlative...

Dopaminergic neurons are fundamental in governing motivation, movement, and many aspects of cognition. The targeted modulation of dopaminergic signaling serves as a cornerstone in developing therap...

biorxiv.org
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So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort! nature.com/articles/s41589-0… #TeamMassSpec #Proteomics #GPCR

Profiling the proximal proteome of the activated μ-opioid receptor

Nature Chemical Biology - A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking...

nature.com
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Massive 10+ year effort in lab spearheaded by @leonardoaparrar and Kayal (secret account 🤔). Unreal cover by @EmmaVIDALL that says it all.
Neuron@NeuroCellPress20 Dec 2023
2023's final issue is out! cell.com/neuron/current Cover story is from @Roy_Lab_Thinks's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here cell.com/neuron/fulltext/S08…
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Nat Biotech recently published a provocative study claiming single synapse RNA-seq. Unfortunately, there is no evidence demonstrating droplet-based sequencing of single synaptosomes. They are likely studying random pieces of cellular debris. Our reply: nature.com/articles/s41587-0…
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We’re THRILLED to have this paper out - exploring how BAMs promote neuroinflammation in a model of PD. Congrats to @amschonhoff and huge thanks to @ASAP_Research @MichaelJFoxOrg @uabmedicine @uab_neurology and the rest of the Harms lab!! nature.com/articles/s41467-0…

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of...

Nature Communications - Neuroinflammatory mechanisms are implicated in Parkinson disease. Here we identify border-associated macrophages (BAMs), as essential for the α-synuclein-mediated...

nature.com
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Proximity labeling is a powerful proteomics approach to map cellular organization of proteins and their interactions, but the multistep sample preparation has restricted scalability. Our new preprint offers a solution: biorxiv.org/content/10.1101/…

An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping

Proximity labeling (PL) coupled with mass spectrometry has emerged as a powerful technique to map proximal protein interactions in living cells. Large-scale sample processing for proximity proteomics...

biorxiv.org
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If you wish to know how a scientist gets trapped between arts and science you might want to give this piece a chance!😂🐘🐘🐘🧠🧠🧠🎶🎹🪕🎻 David Sulzer’s Wild World of Music | The New Yorker newyorker.com/magazine/2023/…

The Wild World of Music

What can elephants, birds, and flamenco players teach a neuroscientist-composer about music?

newyorker.com
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Ben Hobson retweeted
Peter Sims@psimslab24 Feb 2023
How can we kill chemo-resistant glioma cells? Turns out they are uniquely vulnerable to #ferroptosis. Awesome collaboration with @CUBrainTumorLab @MateiBanu combining a new mouse glioma model with human glioma slice culture/scRNA-seq: biorxiv.org/content/10.1101/…

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

Glioma cells hijack developmental transcriptional programs to control cell state. During neural development, lineage trajectories rely on specialized metabolic pathways. However, the link between...

biorxiv.org
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If you thought ATAC was cool, wait til you see DEFND-seq!🛡️🧬🔥 Single-nucleus combined RNA/DNA-seq using the 10x Multiome kit! Amazing work from @olsen_timr
Peter Sims@psimslab10 Feb 2023
Happy to share an approach to high-throughput, joint single-nucleus RNA/DNA-seq. Basically: prep nuclei for snATAC-seq badly on purpose and feed to the 10x Multiome kit for RNA/ATAC. Gives high-complexity RNA/DNA libraries instead. Hat-tip @olsen_timr: biorxiv.org/content/10.1101/…

Scalable co-sequencing of RNA and DNA from individual nuclei

The ideal technology for directly investigating the relationship between genotype and phenotype would analyze both RNA and DNA genome-wide and with single-cell resolution. However, existing tools...

biorxiv.org
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This is a great collection of reviews on the immune system in PD, including from @arlehamn @SetteLab and many others! @david_sulzer and I wrote about neuronal antigen presentation: content.iospress.com/article…

Neuronal Presentation of Antigen and Its Possible Role in Parkinson’s Disease - Benjamin D. Hobson,...

Patients with Parkinson’s disease (PD) and other synucleinopathies often exhibit autoimmune features, including CD4+ and some CD8+ T lymphocytes that recognize ...

journals.sagepub.com
Journal of Parkinson's Disease@journal_PD1 Dec 2022
Growing evidence for the role of the immune system in PD: Experts review the latest evidence for the link between immune activation and neuroinflammation and PD in this new supplement issue: tinyurl.com/PDimmunesystem. #parkinsons #immunesystem @basbloem @kalialabs
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Ben Hobson retweeted
Ali Mohebi@mohebial7 Nov 2022
Folks- I have a preprint update on our #dopamine quest: "Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens". I will try to summarize it here: biorxiv.org/content/10.1101/… 1/9

Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: 1)...

biorxiv.org
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