@BednarLab

Pancreatic cancer research, epigenetics, tumor immunology, tumor evolution, surgeons doing basic science, UM PanTErA, #NewPISlack, personal Twitter: @Fil_Bednar

 University of Michigan
Joined August 2019
  • Tweets354
  • Following351
  • Followers588
25Media
Anyone even remotely interested in tumor biology and metabolism should line up!
Katherine Aird@airdlab
Apr 11
Looking for a postdoc position and attending AACR in San Diego? I'll be there, too, and the lab is actively recruiting! Send me an email with your CV and cover letter, and I’ll follow up if there is a mutual fit. See more about our research at airdlab.com.

Aird Lab

airdlab.com
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In Memoriam: Professor Greg Hannon (1964–2026) cruk.cam.ac.uk/news/in-memor… cruk.cam.ac.uk/news/in-memor…

In Memoriam: Professor Greg Hannon (1964–2026) - Cancer Research UK Cambridge Institute

cruk.cam.ac.uk
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Really nice work highlighting the role of stroma-produced PAI-1 and tPA in the modulation of pancreatic cancer immune response by our colleague, Kyoung Lee! @UMICHpancreas science.org/doi/10.1126/scia…

A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer

Stromal PAI1 promotes immunosuppression and tumor progression in pancreatic cancer by inhibiting tPA.

science.org
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Biology is not static -- proteins are constantly being made, modified, and destroyed as cells live, respond, and adapt. Each cell interacts with other cells and its matrix to shape its proteome and dynamic responses. That’s why understanding in vivo proteome dynamics at the level of individual cells is one of the most exciting frontiers in understanding biological systems. 1/2
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Bednar lab retweeted
Anirban Maitra@Aiims1742
Jan 23
Cover article of @CR_AACR by @Pasca_Lab @UMICHpancreas Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression aacrjournals.org/cancerres/a… Very nice study with autochthonous models to track the fate of WT1+ fibroblasts and impact of depletion on natural history.
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Preprint from @UMICHpancreas (Eileen Carpenter): Longitudinal analysis of matched patient biospecimens reveals neural reprogramming of Cancer-associated fibroblasts ("NR-CAFs") following chemotherapy in #PancreaticCancer biorxiv.org/content/10.64898…
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I’m thrilled to introduce you to the NeuMap! our latest work in @Nature. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour-de-force 🗺️ @AndrsHidalgo16 nature.com/articles/s41586-0…

Architecture of the neutrophil compartment

Nature - Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state...

nature.com
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Sharing our new preprint: In mice, lipid-rich diets prior to oncogenic Kras activation accelerate tumorigenesis and remodel epithelial-stromal plasticity and dynamics. Thanks to our outstanding co-first authors @kaur_urvinder and @erifaraoni biorxiv.org/content/10.1101/…

Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice

Dietary macronutrient composition has emerged as a key modulator of pancreatic tumorigenesis, yet the impact of lipid-rich diets, particularly ketogenic diets (KD) on the earliest stages of pancrea...

biorxiv.org
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Biology is not random. And so if you measure any aspect of it a lot of times and compare your data to a random model you will eventually rederive this fact. The problem with absurdly small p-values is that, because you can essentially always get them by juicing your sample size, when you see something like p < 10^-300 what it’s really saying is THAT biology is non-random, which we already knew, and not HOW it is non-random, which is what we really care about.
Michael 英泉 Eisen
@mbeisen
28 Nov 2025
The first rule of Data Science - if your p-value is less than 1 over the number of atoms in the universe, you're using the wrong model.
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COLLECTION of papers on Spatial Transcriptomics of IPMNs (Cystic Precursor lesions of #PancreaticCancer): aacrjournals.org/clincancerr… aacrjournals.org/cancerdisco… aacrjournals.org/clincancerr… science.org/doi/10.1126/scia… nature.com/articles/s41467-0… biorxiv.org/content/10.1101/… biorxiv.org/content/10.1101/…
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1/ You think your ML model fails because it’s “not powerful enough”? No. It’s your data. Garbage in, garbage out. Here’s what most AI scientists miss when using public RNA-seq or single-cell data 👇
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We're excited to kick off the 2nd annual PancMidwest Symposium. We'll have two days of presentations, posters and networking among pancreatic cancer researchers in the region.
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Kudos to @PanCAN for creating the SPARK data platform containing vast troves of clinical, imaging, laboratory & molecular data from Precision Promise and Know Your Tumor. Fabulous resource for #PancreaticCancer researchers in both academia and industry. @sdosssdoss
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PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.
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Abstract titles for the 2025 @AACR special conference on #PancreaticCancer in Boston are now online: aacr.org/wp-content/uploads/… Full program: aacr.org/meeting/aacr-specia… #AACRPan25 Hope to see many of you there @ednacukierman @lauradelongwood @isteaus @lustgartenfdn @letswinpc
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A special @jclinicalinvest series on #PancreaticCancer led by @BenStanger01 jci.org/articles/view/191936 jci.org/articles/view/191937 jci.org/articles/view/191940 jci.org/articles/view/191943 jci.org/articles/view/191944 Articles by @lauradelongwood @Muir_Lab @MaddipatiLab
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Excited to co-chair with @lauradelongwood @isteaus #AndyAguirre & @DavidTuveson Submit your abstract!! #AACRpan25 #PancreaticCancer
AACR
@AACR
27 Jun 2025
Submit an abstract by July 15 for the AACR Conference on Advances in Pancreatic Cancer Research (Sept 28-Oct 1; Boston), chaired by Andrew J. Aguirre, @EdnaCukierman, Susan Tsai, David Tuveson, and Laura DeLong Wood. brnw.ch/21wTK6Y #AACRpan25 @isteaus @lauradelongwood
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Coming out party / preprint for @Vince_BernPag who starts his faculty position @MDAndersonNews in a week. This study identifies adaptive responses to radiation therapy in pancreatic cancer using single cell & spatial profiling, resulting in persister cell populations post XRT.
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Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period grants.nih.gov/grants/guide/…
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New editorial in @AGA_CMGH. I highlight elegant work by @Charles_C_33, @millsjc67 and colleagues showing how blocking ribosome biogenesis in vivo disrupts acinar cell homeostasis and suppresses tumorigenesis. 🔗Editorial: cmghjournal.org/article/S235… 🧬Paper: cmghjournal.org/article/S235…
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