@AriasAAS

Bacteriologist 🧫 | Immunology explorer 🧬 | Forever chasing the secrets of the immune system.

 Medellín, Colombia, South Amer
Joined September 2025
  • Tweets65
  • Following199
  • Followers14
6Media
¡Gran oportunidad de actualización académica e investigación! 🔴 XXVIII Congreso Tópicos Selectos de Infectología 2026. 3 días de aprendizaje y reflexión sobre los grandes desafíos de las enfermedades infecciosas extension.medicinaudea.co/ev… @microudea @Medicina_UdeA
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🥇 Primer puesto en Trabajos de investigación, modalidad póster, con: “Clinical, immunological, and genetic characterization of otherwise healthy Latin American patients with Conidiobolomicosis.”
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extension.medicinaudea.co/ev…

Tópicos selectos de infectología | Medicina UdeA

XXVIII Congreso Tópicos Selectos de Infectología 2026 de Medicina UdeA. Actualización en enfermedades infecciosas, resistencia antimicrobiana y tuberculosis.

extension.medicinaudea.co
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Management change following NGS diagnosis of inborn errors of immunity: The Australasian experience rupress.org/jhi/article/2/6/… 👍👏👏👏
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Management change following NGS diagnosis of inborn errors of immunity: The Australasian experience rupress.org/jhi/article/2/6/…
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💙 Today is APDS Awareness Day 💙 Activated PI3K Delta Syndrome (#APDS) is a rare Primary Immunodeficiency caused by changes in the PIK3CD or PIK3R1 genes. It affects roughly 1 to 2 people per million, and because its symptoms can look like more common conditions, many families spend years searching for answers. People living with APDS may experience recurrent infections, swollen lymph nodes, an enlarged spleen, chronic inflammation, and autoimmune symptoms. The median time to an APDS diagnosis is 7 years. Seven years of appointments, of infections, of not knowing why. APDS can be confirmed through genetic testing, and because it can be inherited, testing may also be recommended for at-risk family members. Earlier diagnosis means earlier care. That's why awareness matters. 💙 #APDSAwarenessDay #APDS #PrimaryImmunodeficiency #RareDisease #EarlyDiagnosis #GeneticTesting #PIAwareness
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Current Affairs: Tissue flow creates mechanical cues to coordinate immune-cell migration during development 📹 Hoang Anh Le et al @mayor_lab UCL, London in @NatureCellBio ➡️ bpod.org.uk/archive/2026/9/3… with @AntDLewis
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Casanova Lab@casanova_labAug 20
The first study of STAT1 GOF in Africa: STAT1 gain-of-function in 12 Moroccan patients: Clinical and genetic insights rupress.org/jhi/article/2/5/…

STAT1 gain-of-function in 12 Moroccan patients: Clinical and genetic insights

STAT1 gain-of-function mutations cause chronic mucocutaneous candidiasis and broad immune dysregulation, yet African data are limited. In a Moroccan cohort

rupress.org
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APDS is a rare inborn error of immunity classified as a group of combined #immunodeficiency; however, because specific treatments for APDS are available, early diagnosis and therapeutic intervention are crucial for improving patient prognosis. (1/2) hubs.la/Q04qSZs10
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3/ The mutant IL23R proteins display lower levels of cell surface expression for some of these IL-23R variants (R381Q and G300V) and/or conformational changes affecting the efficacy of the agonist with respect to STAT3 phosphorylation (L372F, G149R, R381Q and G300V).
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2/ Of all the IL23Rvariants present in homozygosity in our own and public databases, we found that 4 were hypomorphic: 3 rare (G300V, G149R, and L372F) and one common (R381Q).
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1/ We are delighted to share our work published in @JExpMed identifying homozygous rare and common IL23Rhypomorphic variants underlying tuberculosis (doi.org/10.1084/jem.20252236).

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

We report four rare or common hypomorphic IL23R variants that, when present in the homozygous state, impair IFN-γ production by innate-like T and NK cells,

rupress.org
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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis rupress.org/jem/article/223/…

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

We report four rare or common hypomorphic IL23R variants that, when present in the homozygous state, impair IFN-γ production by innate-like T and NK cells,

rupress.org
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I’m honored to have contributed to this important study led by @casanova_lab and @BoissonDupuis , now published in the Journal of Experimental Medicine. It has been a privilege to collaborate with such an outstanding international team. Congratulations to all the authors! 🔗
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Waggoner Lab@LabWaggonerJul 9
4 rare or common hypomorphic IL23R variants that, when homozygous, impair IFN-γ production by innate-like T and NK cells, thereby conferring a predisposition to tuberculosis @JExpMed rupress.org/jem/article/223/… @casanova_lab @BoissonDupuis @BustamanteJaci1 @anne_puel
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Casanova Lab@casanova_labJun 11
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org
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Interesting things
@awkwardgoogleJul 8
This video explains all the different blood types
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Casanova Lab@casanova_labJul 7
The benefit of newborn screening: Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report rupress.org/jhi/article/2/5/…

Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report

Winestone et al. demonstrate that in 796 children with SCID transplanted with nonsibling donors between 1982 and 2020, survival was 18.8% lower among Black

rupress.org
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Massimo
@Rainmaker1973Jul 8
Problem solving skills: ants vs humans
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