@AranyLab

We are the Arany lab at University of Pennsylvania. We love metabolism !

 University of Pennsylvania
med.upenn.edu/aranylab/
Joined December 2019
  • Tweets237
  • Following186
  • Followers1.4K
33Media
New! Online now: Quantification of nutrient fluxes during acute exercise in mice dlvr.it/TFMr8Y
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The Arany lab retweeted
Cell@CellCellPress1 Aug 2024
From our newest anniversary focus issue on #Metabolism! "Human cardiac metabolism" @AranyLab @PennMedicine & colleagues Read the review: cell.com/cell-metabolism/abs… #50YearsofCell
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PennCVI@PennCVI25 Jul 2024
CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/3904…
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Boa Kim
@BoaKim56 May 2024
I am pleased to share a preprint ‘HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal cell carcinoma’. biorxiv.org/content/10.1101/…

HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal...

Clear cell renal cell carcinomas (ccRCC) are largely driven by HIF2α and are avid consumers of glutamine. However, inhibitors of glutaminase1 (GLS1), the first step in glutaminolysis, have not shown...

biorxiv.org
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New manuscript from our group studying DCM-TTNtvs and transcriptional modulators that reverse haploinsufficiency. ahajournals.org/doi/10.1161/…

CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation...

BACKGROUND: TTN truncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease with high morbidity and mortality rates. TTNtvs reduce...

ahajournals.org
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Ben Prosser@Prosser_Lab17 Jan 2024
Interested in TTN/DCM? Check out current edition of @jclinicalinvest. 2 new reports: 1 by us w/ @Arany Lab and 1 from Miklos Kellermayer, plus commentary by @TravisHinson and Stuart Campbell. We know a lot more about TTN pathomechanisms! ...and we know what we don't know. 🧵1/4
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NEJM
@NEJM13 Jan 2024
Review Article by Zoltan Arany, M.D., Ph.D. (@AranyLab): Peripartum Cardiomyopathy nej.md/48pUCx3 #Cardiology

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High fat consumption & blood pressure elevation ft. @BoaKim5, @WencaoZhao, Soon Tang, @MGLevin, @_AyonIbrahim, Yifan Yang, Ling Lai, Jian Li, @FitzGerald__Lab, @AranyLab (@PennCVI/ @PennIDOM) Emilia Roberts & Richard Assoian (@PennSysPharmATT) tinyurl.com/35b3tfm5
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PennCVI@PennCVI5 Dec 2023
CVI is accepting applications for AHA Summer Undergraduate Fellowships! Students who are underrepresented in medicine encouraged to apply. Application deadline is Feb 14, 2024. med.upenn.edu/cvi/american-h… #undergraduatefellowships #cardiologyresearch
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Ben Prosser@Prosser_Lab14 Nov 2023
Here w/ @AranyLab we reveal another piece of the puzzle of how #titin mutations cause DCM! Quentin shows (in patient 💔) that truncated titin is made, incorporates into the sarcomere and bears load upon stretch… but not as well as full length titin! tinyurl.com/3uu6cfhe
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Below is data we were able to share at @CPPCongress this year representing early findings from the PPCM-R! We are so excited to continue seeing survivors register and grow our understanding of PPCM 👏
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New paper alert! Led by @AlexiaVite93 : Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes sciencedirect.com/science/ar… @JACCJournals @AranyLab @DanKellyPennCVI @PennCVI @kbedi88
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PPCM_Registry@PpcmRegistry3 Oct 2023
We are excited to add a feature on the PPCM-R! Now when you complete surveys you will be able to see graphs showing other survivor data on the sections you completed! Check it out 🫀 #PPCM #MedTwitter #CardioEd #CardioTwitter #Cardiology #CardioOB
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Our PhD Admissions system is open!!!! No application fee this year. We hope to see your application soon and please reach out if you have any questions.
Penn BGS@pennbgs2 Oct 2023
We are pleased to announce that we are now accepting BGS applications for Fall 2024 until December 1st! Please see our Admissions page for more info and how to apply: med.upenn.edu/bgs/phd-applic…
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Carl June and Michel Sadelain created CAR T immunotherapy, modifying the body's T cells to fight cancer. For this advance they are awarded 2024 Breakthrough Prize in Life Sciences. breakthroughprize.org/News/8… @MSKCancerCenter @Penn @PennMedicine
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Join @Cell_Metabolism editor Dr. Allyson Evans for the @KeystoneSymp, Circulating Metabolic Intermediates as Fuels and Signals. Register today: hubs.li/Q02076l_0 #KSMetabolites24
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PennMuscle@PennMuscle24 Aug 2023
We are looking forward to seeing everyone in October as we celebrate 50 years of the Pennsylvania Muscle Institute! 2023 PMI Annual Symposium: "Celebrating 50 Years of Muscle, Motors, and the Cytoskeleton" on Mon. 10/16/23. Register now: med.upenn.edu/pmi/events/pmi…
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Marc Bornstein from the Arany lab @AranyLab defends on Monday!
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Tons of promising work using CAR T cells beyond cancer. Already showing signs of efficacy in early clinical reports. Check out our review in @Nature of this rapidly evolving field! W/ @AranyLab @BaurLab @jonepstein1 @carlhjune nature.com/articles/s41586-0…
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The Arany lab retweeted
Eric Topol
@EricTopol29 Jul 2023
The ability to engineer our cells to potentially prevent or cure diseases has gone to new heights science.org/doi/full/10.1126… @ScienceMagazine by @ferrari_sam93 @NaldiniLab nature.com/articles/s41586-0… @Nature by @daniel_baker_j @carlhjune @AranyLab @BaurLab @jonepstein1 @PennMedicine
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