@AlexWalkerPath

Postdoc with @PeterJCullen @BristolBiochem, formerly postdoc @YamauchiLab @CMMBristol and DPhil Student @fodorlab @Dunn_School. Biology 🦠🧬 and food! 🍕🥐

Joined August 2019
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Using virion vRNPs, together with purified proteins, we have, for the first time, recreated the switch from influenza virus transcription to replication, AND a full cycle of genome replication inside a test tube🧪@AmandaZihanZhu @haitian_fan @PLOSBiology ➡️journals.plos.org/plosbiolog…

Defining the minimal components of the influenza A virus replication machinery via an in vitro...

The influenza A virus genome is composed of eight single-stranded RNA segments. This study reconstitutes the replication of RNA genome segments in a test tube, using purified viral and host proteins,...

journals.plos.org
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Delighted to share that our structure of the endosomal Commander complex is now published in @CellCellPress! cell.com/cell/fulltext/S0092…

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Complete structural model and functional validation of the sixteen-subunit human Commander complex reveals mechanisms of assembly and how mutations causing Ritscher-Schinzel syndrome perturb stabil...

cell.com
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The tale of influenza viruses Part II: Molecular Replication, sister to its transcription-focused Part I, is now aired online in Trends in Microbiology! Click here ⬇️ to check out the most recent structural updates on influenza virus genome replication! sciencedirect.com/science/ar…
Influenza virus ribonucleoprotein complex during genome replication.

ALT Influenza virus ribonucleoprotein complex during genome replication.

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Our study on a novel role of host factor ANP32 in influenza virus genome replication has been published on @NAR_Open academic.oup.com/nar/advance…, congrats everyone involved @FangzhengWang @Dr_Shepp @StallerEcco @wendybarclay11 @jonathan_grimes @fodorlab @Dunn_School @OxfordStrubi!
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In a world where viruses, scientists and llamas co-exist…. happy to share our work in collaboration with Grimes' lab, on mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies produced in llamas. Check it out! nature.com/articles/s41467-0…
Our lab Llama named 'Brevig Mission' with a 3D printed 1918 RNA polymerase on his head <3

ALT Our lab Llama named 'Brevig Mission' with a 3D printed 1918 RNA polymerase on his head <3

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Really happy to see this piece of work out. With @amandaz83411502 we structurally and functionally characterised 24 nanobodies against the 1918 influenza virus polymerase. @fodorlab @jonathan_grimes @OxfordStrubi @Dunn_School rdcu.be/cELs3
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It's Flu awareness week and @DiamondLightSou arranged for an animation of some of our recent work on the influenza polymerase. @CarriqueLoic @AlexWalkerPath @jonathan_grimes @fodorlab @StallerEcco @OxfordStrubi @Dunn_School
Diamond Light Source@DiamondLightSou22 Oct 2021
Replying to @DiamondLightSou @WHO_Europe
This animation with @UniofOxford explores how the flu virus interacts with our bodies. Knowing the structure and function of this stabilising protein will enable scientists to work on new treatments to fight the disease. @STFC_Matters @BBSRC @wellcometrust
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Congratulations to Alex @AlexWalkerPath on passing his DPhil viva @Dunn_School ! Enjoy your postdoc in Bristol with @YamauchiLab !
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Nice work @M_L_Knight @haitian_fan @fodorlab @OxfordStrubi.
Structural Biology Communications@ActaCrystF30 Jun 2021
M​ichael L. Knight et al.: Structure of an H3N2 influenza virus nucleoprotein #Influenza #RNABindingProtein #Nucleoprotein @UniofOxford ... #IUCr scripts.iucr.org/cgi-bin/pap…
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Alex @AlexWalkerPath from @Dunn_School presents his work on SARS-CoV-2 RNA capping at @MicrobioSoc #Microbio21. See biorxiv.org/content/10.1101/… for details.
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Another stunning talk from @AlexWalkerPath on how 'mutation of a Flu polymerase 3' RNA promoter binding site inhibit transcription elongation' was delievered! Great work! #IUM2020 #Influenza
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Socially distanced cake celebration for our @nature paper nature.com/articles/s41586-0… 🎉 Congratulations again to all first authors @CarriqueLoic @haitian_fan @JeremyKeown1 @AlexWalkerPath @jonathan_grimes and Ervin! #influenza #cake
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Many congratulations to all the winners at today's Graduate Student Symposium! 🏅🏅🏅 1st year poster prize: Shengpan Zhang (Sattentau group) 2nd year poster prize: @RuthKetley (Gullerova group) and @lu_fangfang (@freeman_lab) 3rd year talk prize: @AlexWalkerPath (Fodor Group)
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Our virtual progress seminars continue! Last week Nandita Bodra @LeaLabTweets talked about structural work on the complement system. Yesterday, Florian Zobel @IvanAhelLab discussed PARP1 and tomorrow @AlexWalkerPath (Fodor lab) tell us more about his #COVID19 research
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Congrats to #NotOnTwitterErvin for being awarded the Biochemical Society's 2019 @ASTRAZENECAUK Award! @Dunn_School
Biochemical Society@BiochemSoc22 Nov 2019
This morning, Ervin Fodor joined us at #BiochemEvent Transcription in health and disease to present his prize lecture. Congratulations, Ervin, on winning the 2019 @ASTRAZENECAUK Award and thank you for the brilliant talk on influenza virus RNA polymerase #BiochemAwards
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Anyone interested in virus labeling and detection in just 1 minute?! Check out our paper describing how to use calcium, fluorescent DNA and single-particle tracking to do this! nature.com/articles/s41598-0…
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Alex Walker retweeted
Haitian Fan@haitian_fan3 Oct 2019
Very interesting story on dimerization of influenza virus polymerase from #Naffakhlab: #PLOSPathogens: Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the ... dx.plos.org/10.1371/journal.…

Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the...

Author summary Influenza viruses, because of their yearly recurrence and the occasional emergence of pandemics, represent a worldwide major public health threat. Enhancing the fundamental knowledge...

journals.plos.org
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Away day! Off to Uni Bristol to @YamauchiLab's Frontiers Bristol conference! #selfiestick
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No, not some amazing new data... the #FodorLab trying to understand Twitter analytics 🤣🤣🤣 (thanks for the tutoral, @AlexWalkerPath!)
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Check out our new pre-print on dynamics of influenza RNA during replication initiation and a big thank you to everyone who contributed! @aj_velthuis @AchillesKap
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