@AlexWalkerPath

Postdoc with @PeterJCullen @BristolBiochem, formerly postdoc @YamauchiLab @CMMBristol and DPhil Student @fodorlab @Dunn_School. Biology 🦠🧬 and food! 🍕🥐

Joined August 2019
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Really glad to contribute to this work led by the crazy-talented (although not on social media!) Rebeka Butkovic 🎉 An exciting first step into the fascinating world of cell biology! 🧪🧫
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Using virion vRNPs, together with purified proteins, we have, for the first time, recreated the switch from influenza virus transcription to replication, AND a full cycle of genome replication inside a test tube🧪@AmandaZihanZhu @haitian_fan @PLOSBiology ➡️journals.plos.org/plosbiolog…

Defining the minimal components of the influenza A virus replication machinery via an in vitro...

The influenza A virus genome is composed of eight single-stranded RNA segments. This study reconstitutes the replication of RNA genome segments in a test tube, using purified viral and host proteins,...

journals.plos.org
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Delighted to share that our structure of the endosomal Commander complex is now published in @CellCellPress! cell.com/cell/fulltext/S0092…

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Complete structural model and functional validation of the sixteen-subunit human Commander complex reveals mechanisms of assembly and how mutations causing Ritscher-Schinzel syndrome perturb stabil...

cell.com
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The tale of influenza viruses Part II: Molecular Replication, sister to its transcription-focused Part I, is now aired online in Trends in Microbiology! Click here ⬇️ to check out the most recent structural updates on influenza virus genome replication! sciencedirect.com/science/ar…
Influenza virus ribonucleoprotein complex during genome replication.

ALT Influenza virus ribonucleoprotein complex during genome replication.

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Ready for #NSV2022 after a cancelled flight led to an unexpected journey to Heathrow airport! ✈️ Excited to catch up with old friends and make some new ones!
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Our study on a novel role of host factor ANP32 in influenza virus genome replication has been published on @NAR_Open academic.oup.com/nar/advance…, congrats everyone involved @FangzhengWang @Dr_Shepp @StallerEcco @wendybarclay11 @jonathan_grimes @fodorlab @Dunn_School @OxfordStrubi!
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Glad to see this out, congrats everyone!
Lia Yosaatmadja@shotliverfreak17 Jan 2022
Our NSP14 baby academic.oup.com/nar/advance… is finally out today @NAR_Open. Can't thank @JeremyKeown1 @haitian_fan from @fodorlab and @jonathan_grimes lab, @SchofieldOxford , @ogileadi and McHugh lab enough for their support and hard work to get this to the finish line ❤️.

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in...

Abstract. The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-CoV-2 belongs to an order, Nidovirales, with very large RNA g

academic.oup.com
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In a world where viruses, scientists and llamas co-exist…. happy to share our work in collaboration with Grimes' lab, on mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies produced in llamas. Check it out! nature.com/articles/s41467-0…
Our lab Llama named 'Brevig Mission' with a 3D printed 1918 RNA polymerase on his head <3

ALT Our lab Llama named 'Brevig Mission' with a 3D printed 1918 RNA polymerase on his head <3

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Really happy to see this piece of work out. With @amandaz83411502 we structurally and functionally characterised 24 nanobodies against the 1918 influenza virus polymerase. @fodorlab @jonathan_grimes @OxfordStrubi @Dunn_School rdcu.be/cELs3
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Just out today, our contribution to understanding #SARSCoV2! We show that the viral polymerase is involved in capping the viral RNA. With thanks to @fodorlab @haitian_fan @JeremyKeown1 @M_L_Knight @jonathan_grimes academic.oup.com/nar/advance…

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

Abstract. SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant m

academic.oup.com
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It's Flu awareness week and @DiamondLightSou arranged for an animation of some of our recent work on the influenza polymerase. @CarriqueLoic @AlexWalkerPath @jonathan_grimes @fodorlab @StallerEcco @OxfordStrubi @Dunn_School
Diamond Light Source@DiamondLightSou22 Oct 2021
Replying to @DiamondLightSou @WHO_Europe
This animation with @UniofOxford explores how the flu virus interacts with our bodies. Knowing the structure and function of this stabilising protein will enable scientists to work on new treatments to fight the disease. @STFC_Matters @BBSRC @wellcometrust
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Congratulations to Alex @AlexWalkerPath on passing his DPhil viva @Dunn_School ! Enjoy your postdoc in Bristol with @YamauchiLab !
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Nice work @M_L_Knight @haitian_fan @fodorlab @OxfordStrubi.
Structural Biology Communications@ActaCrystF30 Jun 2021
M​ichael L. Knight et al.: Structure of an H3N2 influenza virus nucleoprotein #Influenza #RNABindingProtein #Nucleoprotein @UniofOxford ... #IUCr scripts.iucr.org/cgi-bin/pap…
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Alex @AlexWalkerPath from @Dunn_School presents his work on SARS-CoV-2 RNA capping at @MicrobioSoc #Microbio21. See biorxiv.org/content/10.1101/… for details.
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New preprint alert 🚨 Our latest SARS-CoV-2 work, showing that one of the domains in the viral RNA polymerase is an enzyme involved in viral RNA capping (and this reaction is inhibited by remdesivir TP)!
Fodor Laboratory@fodorlab18 Mar 2021
Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase disq.us/t/3vmk30i
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Another stunning talk from @AlexWalkerPath on how 'mutation of a Flu polymerase 3' RNA promoter binding site inhibit transcription elongation' was delievered! Great work! #IUM2020 #Influenza
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Socially distanced cake celebration for our @nature paper nature.com/articles/s41586-0… 🎉 Congratulations again to all first authors @CarriqueLoic @haitian_fan @JeremyKeown1 @AlexWalkerPath @jonathan_grimes and Ervin! #influenza #cake
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We present the first structures of influenza virus polymerase bound to an essential host factor, and these give us some amazing insights into how the #flu virus replicates/adapts for new hosts! Congratulations everyone @CarriqueLoic @haitian_fan @JeremyKeown1 @jonathan_grimes
Jeremy Keown@JeremyKeown118 Nov 2020
nature.com/articles/s41586-0… @CarriqueLoic @haitian_fan @AlexWalkerPath @jonathan_grimes #notontwitterErvin. We solved a series of structures using #cryoEM of the ANP32-Influenza polymerase complex, and investigated it using functional assays. @OxfordStrubi @Dunn_School @NDMOxford
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Many congratulations to all the winners at today's Graduate Student Symposium! 🏅🏅🏅 1st year poster prize: Shengpan Zhang (Sattentau group) 2nd year poster prize: @RuthKetley (Gullerova group) and @lu_fangfang (@freeman_lab) 3rd year talk prize: @AlexWalkerPath (Fodor Group)
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Our virtual progress seminars continue! Last week Nandita Bodra @LeaLabTweets talked about structural work on the complement system. Yesterday, Florian Zobel @IvanAhelLab discussed PARP1 and tomorrow @AlexWalkerPath (Fodor lab) tell us more about his #COVID19 research
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