@AlexWTarr

Virologist at the University of Nottingham. Researching virus entry pathways and antiviral immunity

Joined February 2012
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Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex biorxiv.org/content/10.1101/…

Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific...

Entry of Zaire e bolavirus (EBOV) into a host cell is a complex process requiring interactions between the viral glycoproteins (GP) and cellular factors. These entry factors are cell-specific and can...

biorxiv.org
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Congratulations to Dr Richard Brown at PEI for a great paper on SARS-CoV-2 published today in PNAS news.rub.de/english/press-re…

The Route Into the Cell Influences the Outcome of Sars-Cov-2 Infection | Newsportal - Ruhr-Univer...

A surface protein helps viruses to enter cells. This has far-reaching consequences for the infection.

news.rub.de
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Our study on the development of a simple low-cost pathway to accurately subtype #HepatitisC in sub-Saharan Africa has just been published in the Journal of Medical Virology. 👇🏽 @PostdocPat @JonathanKBall @AlexWTarr @UoNLifeSci @OneVirology onlinelibrary.wiley.com/doi/…

Hepatitis C subtyping assay failure in UK patients born in sub‐Saharan Africa: Implications for...

Background and Aims The newly developed direct-acting antivirals have revolutionized the treatment of chronic hepatitis C virus (HCV), with cure rates as high as 98% in some cohorts. Although...

onlinelibrary.wiley.com
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Another preprint from our group! How to easily sub-type the incredibly diverse #HepatitisC #virus with genomes from Sub-Saharan Africa that most commercial assays fail upon. @PostdocPat @JonathanKBall @UoNLifeSci #HCV 👇🏽 medrxiv.org/content/10.1101/…

Hepatitis C subtyping assay failure in UK patients born in Sub-Saharan Africa: implications for...

The newly developed direct-acting antivirals (DAAs) have revolutionised the treatment of chronic hepatitis C virus (HCV), where cohort studies have shown that cure rates as high as 98% can be...

medrxiv.org
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Replying to @nottmhospitals
@nottmhospitals and @UoNLifeSci researchers report rare bifacial weakness with paraesthesias variant of Guillain-Barré syndrome in four cases following ChAdOx1 SARS-CoV-2 vaccine. doi.org/10.1002/ana.26144 Vaccination remains extremely safe and the benefits far outweigh the risks.

Guillain–Barré Syndrome Variant Occurring after SARS‐CoV‐2 Vaccination

Although SARS-CoV-2 vaccines are very safe, we report 4 cases of the bifacial weakness with paresthesias variant of Guillain–Barré syndrome (GBS) occurring within 3 weeks of vaccination with the...

onlinelibrary.wiley.com
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Our Retrospective SARS-2 screening work is now published! Several missed cases, incl one of the first known community transmissions in the UK. Great collaborative effort with @JonathanKBall, @PostdocPat, @Theo_Tsoleridis, @mattloose, #NHS and many more! doi.org/10.1099/jgv.0.001595
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Chuffed to have what might sadly be our final chapter on the #HCV p7 channel accepted at @eLife Huge team effort, many not on twitter, but thanks to those on here @OncoVirus_Leeds @ToshanaFoster @AbiBloy @HarrisLabLeeds @AlexWTarr @Stonehouse_Lab doi.org/10.7554/eLife.52555

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for...

Exploiting virus-encoded ion channels as drug targets drove a multi-faceted approach to deriving potent small molecules targeting HCV p7, simultaneously providing new insights into its fundamental...

elifesciences.org
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Yes, unexpectedly found myself working on a serology study on SARS-CoV-2! Pseudotypes with @rich_urbanowicz, we're rushing to get this completed and submitted...
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Congrats to all involved, this is a really interesting study and a great resource for the HCV research community
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High throughput #Covid19 #serology with @paddy_tighe5 and his #robot_army.
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Great to be involved in the recruitment for the @UniofOxford #Chadox #Covid19 #Vaccine trial.
One Virology@OneVirology
19 Jun 2020
Congratulations to the @UoNLifeSci team for today completing antibody testing for recruitment to the #covid19 #vaccine trial @AlexWTarr @paddy_tighe5 #Neiloldfield #davidturner @NottmBRC @UoNresearch @UoNPressOffice
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New paper published in Journal of Clinical Virology 'Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing' bit.ly/2YAGgaC @stuartastbury @AlexWTarr
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A project we started back in 2016, before extraction-free amplification was all the rage! 'Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing' sciencedirect.com/science/ar…
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Latest research just published by the @UoNLifeSci @UoNresearch virology group on human bocavirus infections.
Patrick McClure@PostdocPat
29 May 2020
Pleased to get this study on human #bocavirus published recently with @ViroGem and @AlexWTarr; plenty of it about and severe in a few instances unfortunately: sciencedirect.com/science/ar…
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A small milestone reached in #Covid_19 @UoNresearch today - 600th #Nottingham sample prepared for antibody testing by @AlexWTarr and #PaddyTighe at @UoNLifeSci virology labs.
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Health officials say a third UK case of #coronavirus has been confirmed in a patient who caught it in an Asian country other than China. The person's being treated in a specialist unit. Jonathan Ball is Professor of emerging viruses at The University of #Nottingham:
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Barney King from @OneVirology @UniNottinghamIC telling us about 'hard to pseudotype' viruses with #HepatitisC as as a model. Even clones within same patient behave differently!
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This about as current as it gets: Pseudotypes used to assess cell entry of 2019-nCoV via ACE2 biorxiv.org/content/10.1101/…
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Just bumped into our new cleaner working hard in the lab!
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Will irving gets basl award for being totally fabulous #BASL
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