The lab of Alex Green in the Biomedical Engineering Department at Boston University
Boston, Massachusetts
Joined July 2019
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Our paper on SNIPR riboregulators with SNP specificity is out today in @CellCellPress! SNIPRs can identify point mutations in bacteria and paper-based diagnostics for portable genotyping and drug-resistance testing.
New Resource online now at Cell: Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators zpr.io/twj4m
AlexGreenLab retweeted
Congratulations to Julien Berro @BerroLab @Yale and Alexander Green @AlexGreenLab @BioDesignCenter for “Intercepting the Cell’s Hidden Signals via Peptide-Activated RNA Switches.”
AlexGreenLab retweeted
RCSA & @MooreFound announce awards of $1,320,000 to nine teams in the final year of #Scialog: Chemical Machinery of the Cell, an initiative launched in 2018 to advance fundamental understanding of chemical machinery and reactions in the intact cell. bit.ly/3s14uuZ
AlexGreenLab retweeted
Engineers developing mail-in, no-touch, fast-scan test for COVID-19, other outbreaks
News release: news.iastate.edu/news/2020/0…
@ISU_CoE
@IowaStateCBE
#IowaStateInnovates
AlexGreenLab retweeted
Thanks to @NSF for funding our collaborative, RAPID project to design a radically-new diagnostic that uses @AlexGreenLab toe-hold switch design, @PardeeLab cell free system, and our group's resonant sensors for widespread monitoring of #COVID 19 RNA. No reagents. No PPE. Awesome.
AlexGreenLab retweeted
New #resource in the latest issue: high-specificity #RNA toehold-based #sensors allows for discrimination of point #mutations and RNA base #modifications and enables #genotypic #diagnosis for #Ecoli #human samples and #Zika #virus strains bit.ly/38uO54k
AlexGreenLab retweeted
SNIPRs (Single-Nucleotide-Specific Programmable Riboregulators) take aim at disease-related mutations.
biodesign.asu.edu/news/snipr… #ASUResearch @ASUChemistry
SNIPR design software developed by first author Fan Hong is on Github: github.com/Albert09111/SNIPR
Plasmids will also be available on @Addgene soon.
AlexGreenLab retweeted
Looking for some amazing training in Synthetic Biology? Check out the Cold Spring Harbor Synthetic Biology Summer Course! Applications due soon. cshlsynbio.wordpress.com/
AlexGreenLab retweeted
ASU, @UofT develop first direct gene-circuit-to-electrode interface. ow.ly/Juzy50xt6Wv #research @asunews
Check out our latest paper in @NatureChemistry led by @PardeeLab and @ShanaOKelley at the University of Toronto. Creating hybrid biomolecular/electronic systems by interfacing cell-free systems with electrochemical electrodes. nature.com/articles/s41557-0…
Terrific piece covering our work on RNA-based repressors for @asunews and @ASUBiodesign by Richard Harth.
biodesign.asu.edu/news/%E2%8…
AlexGreenLab retweeted
Wyss researchers have developed “Riborepressors” that, when integrated into synthetic gene circuits, enable reporter gene expression to be halted when the right signal is present. This could be applied in diagnostics, therapeutics, and biofabrication. wyss.harvard.edu/news/gene-o…
Proud to have this paper published today in Nature Chemical Biology after a lot of work. We report two new RNA-based repressors that precisely turn off translation and can be used for RNA sensing, circuits, and diagnostics.
Our new paper from @alexgreenlab designed classes of riboregulators that show in-cell translational inhibition and offer programmable RNA-based tools for gene circuit construction. Readable link at rdcu.be/bV5Ps. go.nature.com/2JO1Lhy
Plasmids for the repressors are available for all to try through Addgene: addgene.org/browse/article/2…
Congratulations to Mahmoud Matar Abed for successfully defending his Master's thesis and Suneet Kale for passing his comprehensive exam for the PhD program! Great work!
Our perspective discussing the present and future of research at the interface of synthetic biology and DNA/RNA nanotechnology just came out. Check it out here: portlandpress.com/emergtopli…