@AervaI

Research Scientist with @tuuliel_lab @scilifelab

Joined August 2015
  • Tweets63
  • Following42
  • Followers38
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Very happy to share our latest work from my postdoc with @tuuliel_lab on recalibrating gene expression changes relative to natural dosage variance: biorxiv.org/content/10.1101/…

Recalibrating differential gene expression by genetic dosage variance prioritizes functionally...

Differential expression (DE) analysis is a widely used method for identifying genes that are functionally relevant for an observed phenotype or biological response. However, typical DE analysis...

biorxiv.org
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Ranking genes by "recalibrated" fold changes enriches results for biological processes related to metabolic and regulatory activity, while simultaneously serving as correction against highly variable genes.
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Many thanks to all collaborators and especially my coauthors Aaron, @Pejminister and our great PI @tuuliel! Tuuli recently got funded as a Wallenberg Scholar, so it is safe to say that we are looking for more colleagues in our Swedish-American lab. 4/4
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Philipp Rentzsch retweeted
John Morris@johnomix2 Apr 2024
The Morris Lab at the @DonnellyCentre for Cellular and Biomolecular Research and the University of Toronto is officially open for business, and the lab website is live! Check it out for info on our research and how you can join: morris-lab.org

The Morris Lab

morris-lab.org
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Philipp Rentzsch retweeted
Lappalainen Lab@tuuliel_lab10 May 2023
Folks at #BoG23 and others - I'm recruiting postdocs to my Stockholm and New York teams. Reach out if interested - experimental or computational opportunities in gene expression dosage (talk #39), GWAS+CRISPR+molQTLs, developmental GTEx, etc. science.org/doi/10.1126/scie…

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens

High-throughput single-cell CRISPR screens help in the understanding of noncoding human genetic variants for blood cell traits.

science.org
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Philipp Rentzsch retweeted
Kaitlin Samocha@ksamocha24 Apr 2023
Philipp Rentzsch #GRD23: Many diseases are caused by changes in gene dosage. Genes have varying levels of gene expression in the population. V^G is a metric of dosage variation (introduced here: pubmed.ncbi.nlm.nih.gov/3160…) Now found that haploinsufficient genes have smaller V^G.

Genetic regulatory variation in populations informs transcriptome analysis in rare disease - PubMed

Transcriptome data can facilitate the interpretation of the effects of rare genetic variants. Here, we introduce ANEVA (analysis of expression variation) to quantify genetic variation in gene dosage...

pubmed.ncbi.nlm.nih.gov
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Philipp Rentzsch retweeted
Martin Kircher@KircherLab23 Sep 2022
kircherlab.github.io is recruiting 2 PostDocs (tinyurl.com/HLpostDoc. tinyurl.com/igvfHLpostDoc). Apply by Oct 10, 22. We are part of #IGVF, analyze reg. variant effects (MPRAs/CRISPR screens) and develop new comp. models & tools w/ @JShendure, @NadavAhituv, @malte_spielmann.
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Daniel MacArthur
@dgmacarthur29 Aug 2022
Science media: still tweeting about a terribly designed, underpowered study a week later because it has cool photos and gets clicks. Also science media: what drives scientists to publish studies that don’t replicate???
The New York Times
@nytimes29 Aug 2022
Your doppelgänger is out there, and you may share a lot more than a face with them. nyti.ms/3dRbcP1

Your Doppelgänger Is Out There and You Probably Share DNA With Them (Published 2022)

That person who looks just like you is not your twin, but if scientists compared your genomes, they might find a lot in common.

nytimes.com
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Philipp Rentzsch retweeted
BioDecoded@BioDecoded18 Apr 2022
A framework to score the effects of structural variants in health and disease | Genome Research genome.cshlp.org/content/32/… #Bioinformatics
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Philipp Rentzsch retweeted
Lappalainen Lab@tuuliel_lab22 Feb 2022
We're looking for a postdoc in Stockholm! Co-mentored position at the intersection of biology/genomics and ML. Fantastic environment at @KTHuniversity & @scilifelab's Data Driven Life Science community, with strong international networks. Please RT! kth.se/en/om/work-at-kth/led…
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My PI is looking for a new PostDoc (biostars.org/p/9486861/) and a PhD student (biostars.org/p/9486464/) in Bioinformatics/Computational Biology on the topic of non-coding variant effects. Deadline Sep 15. I can fully recommend the lab, feel free to contact me if interested
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Now official: the offered positions are part of @genome_gov 's #IGVF consortium in close collaboration with @JShendure and @NadavAhituv. Great science to come, apply now!
Philipp Rentzsch retweeted
bioRxiv@biorxivpreprint12 Jul 2021
CADD-SV - a framework to score the effects of structural variants in health and disease biorxiv.org/cgi/content/shor… #bioRxiv
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New tracks are available for human assemblies, hg19 and hg38. The new tracks show Combined Annotation Dependent Depletion (CADD) scores for each base in the genome and correspond to the v1.6 developmental release. Read more about the release at: genome.ucsc.edu/goldenPath/n… #CADD
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Hello #ESHG2020, visit me at my poster P17.121.B virtualcongress.ctimeetingte… to talk about the newest CADD version CADD-Splice. I am opening a zoom video chat, come and join me!
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Chats at #ESHG2020 posters are disabled/deleted right after presentation. There is not technical necessity for this, its interrupting peoples exchange.
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I am told the chats will be restored/ made available again. Thank you #ESHG2020
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#ESHG2020 talks need to be played at x1.1 speed (some even x1.5) so that speakers do not go over time. Sessions going over time occupy rooms that can not be used by the next session. #virtualconferenceproblems
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#ESHG2020 tip: if a poster (with speaker symbol) doesn't play audio, press ctrl+shift+C in browser, inspect speaker symbol and find aws link to *.ogg file to play audio for that Slide
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