Researching skeletal development, repair, and neoplasia @JohnsHopkins. BST Pathologist @JHUPath.
Joined June 2017
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James Laboratory retweeted
Saturday spotlight💫: Dietary omega-6 lipids drive aberrant tissue repair in #obesity: doi.org/10.1172/JCI205829
🧵 1/2| Obesity is linked to impaired healing, including #HeterotopicOssification (HO), or bone formation, at the injury site. Benjamin Levi & team @UTSW_Surgery implicate dietary #Omega6 lipids in this elevated risk for HO.
@aaronwjames_lab @BTBKGMD
James Laboratory retweeted
Dietary fats drive aberrant tissue repair in #obesity: doi.org/10.1172/JCI205829
Obesity is linked to impaired healing, including #HeterotopicOssification (HO), or bone formation, at the injury site. Benjamin Levi & team @UTSW_Surgery implicate dietary #Omega6 lipids in this elevated risk for HO.
Image: High-fat diet increased COX-2 expression (green) at the HO site in a mouse model. COX-2 dependent prostaglandin E2 production promoted osteochondral differentiation in mesenchymal progenitor cells.
@aaronwjames_lab @BTBKGMD @the_asci
James Laboratory retweeted
Not all #bone-marrow stromal cells are equally good at forming bone. Across 26 donors, higher #ITGA11 levels marked cells with greater bone-forming potential. Sorting by ITGA11 separated stronger from weaker bone-forming cells, suggesting a useful #marker for bone #regeneration.👇
nature.com/articles/s41413-0…
James Laboratory retweeted
We are hiring a Gastrointestinal/Liver Pathologist at the Assistant, Associate, or Professor level. Candidates should have fellowship training or significant experience in GI and/or liver pathology.
Apply: apply.interfolio.com/191825
#Pathology #GIPathology #LiverPathology
James Laboratory retweeted
The U.S. National Institutes of Health (NIH) wants to change a key step in the review process determining which research it funds, raising concerns about transparency and political interference.
Under the new proposal, NIH asserts in a notice posted on 14 August, applications’ numerical ratings would no longer be used for final funding decisions.
Learn more: scim.ag/4xKvqO4
ALT NIH plan to keep peer-review scores for grants secret draws concern
James Laboratory retweeted
The #brain and #nerves directly control bone repair through three levels: central #hormones, peripheral pain signals, and local marrow chemicals. Understanding this neuro-bone chat could spark new therapies for #osteoporosis and fracture healing.👇
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
Excited to share our recent paper in @ScienceTM ! We highlight tendon-associated sensory nerves are not only pain-transmitting fibers, but also protective regulators of tendinopathic changes through FGF1 signaling. Thanks @AaronWJames_Lab. Check it out : science.org/doi/full/10.1126…
Congratulations to first author Dr. Manyu Zhu and team for their work in @ScienceTM 👏👏 Showing for the 1st time that sensory nerves protect against tendon degeneration! Work done @JohnsHopkins @JHUPath
science.org/doi/10.1126/scit…
James Laboratory retweeted
#Hemophilia patients lacking Factor VIII face hidden bone loss, not just bleeding. Replacing this clotting protein restores #bone density, expanding hemophilia care from stopping bleeds to protecting #skeletal health.😀
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
Unwanted #bone growth in soft tissues after #trauma is driven by a protein switch called #PRMT6 that amplifies #inflammation. Targeting it early could prevent this disabling condition while preserving normal tissue repair, offering a precision therapy for injury patients.👇
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
The #spine contains a newly discovered network of lymphatic #vessels that drain brain fluid and control #inflammation. Rewriting long-held anatomy beliefs, this hidden pathway could unlock targeted therapies for #spinal diseases, #nerve damage, and chronic back pain.🥳
@BoneRes_Office
nature.com/articles/s41413-0…
Congrats to Zhao Li and team for their work out today. 👏 👏 Hedgehog signaling implicated in nerve-directed calvarial bone healing! See results here. Work performed at @JohnsHopkins @JHUPath ⬇️ ⬇️ ⬇️
pubmed.ncbi.nlm.nih.gov/4200…
James Laboratory retweeted
After menopause, bone-breaking cells become overactive because they get coated with sugar molecules. Stripping off this sugar could stop bone loss as effectively as estrogen but without hormone therapy's risks.👇
#menopause #bone #hormone
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
Long-term steroid use destroys hip joints by blocking blood flow and killing bone tissue. Understanding these cellular mechanisms offers targets for early intervention and prevention, potentially sparing patients from debilitating joint collapse and replacement surgery.😀
#steroid #bone #joint
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
Bone cells sense how stiff their surroundings are through their microtubule skeleton, directing cell division. This reveals how physical forces guide cartilage repair, pointing to new treatments for joint injuries and osteoarthritis.🧐
#bone #osteoarthritis
@BoneRes_Office
nature.com/articles/s41413-0…
Love this. As the year progresses we are looking for new and talented trainees! Happy to meet potential lab members interested in skeletal neuroscience @ORSsociety meeting #ORS2026
Quiet motivation, pushing you forward into the year ahead.
Happy New Year from the James laboratory @AaronWJames_Lab ✨
#Science #Research #AcademicLife #HappyNewYear2026
James Laboratory retweeted
Quiet motivation, pushing you forward into the year ahead.
Happy New Year from the James laboratory @AaronWJames_Lab ✨
#Science #Research #AcademicLife #HappyNewYear2026
Walking the halls at work, and am so grateful for all lab members (past and present) that helped with our recent achievements. Happy new year and may 2026 bring new knowledge and new journal covers! Photo taken @JHUPath @JohnsHopkins @HopkinsMedicine
James Laboratory retweeted
A bone-strengthening hormone (PTH) relieves chronic back pain by reversing spinal bone thickening and blocking painful nerve growth. This suggests repurposing an existing osteoporosis drug to treat age-related spine degeneration in humans.🧐
#PTH #bone #osteoporosis
@BoneRes_Office
nature.com/articles/s41413-0…
James Laboratory retweeted
Lymphatic vessels in bones and joints drive arthritis and fracture progression. Targeting lymphatic vessels could speed healing and reduce inflammation—offering new drug targets for common musculoskeletal disorders.🥳
#musculoskeletal #bone
@BoneRes_Office
nature.com/articles/s41413-0…
