So well -deserved. Congratulations Shila!
So very pleased to receive this recognition from the Australian Bioinformatics and Computational Biology community 😊 a BIG thank you to mentors, colleagues and members of my team for your positive energy, insights and hard work together!! @abacbs @sydneybioinfo
Alexandra Sharland retweeted
The IMMREP23 @kaggle #TCR-#epitope specificity #MachineLearning #prediction challenge is live now! Spread the word! @airr_community @iRecRepPapers
kaggle.com/competitions/tcr-…
So good to see this important project taking off!
Dr Nicole Mifsud @miffy3005 was awarded $130K by @lungitudefound for research on #immune system rejection of #organ_transplant donor tissue. She will use peptide identification #immunopeptidomics for modulating #T_cell responses to the grafted organ. See: bit.ly/440fPvl

ALT Dr Nicole Mifsud in the laboratory. Our laboratory explores how T cell mediated immune responses contribute to the onset or perpetuation of human disorders (e.g. autoimmunity, allergy) and transplant rejection. A major focus is examining how virus-specific T cells cross-react toward either self or non-self human leukocyte antigen (HLA)/peptide complexes and how this mechanism induces adverse immune responses. We're part of the Monash Biomedicine Discovery Institute, and a member of the Immunity Program and the Department of Biochemistry and Molecular Biology. https://www.monash.edu/discovery-institute/mifsud-lab/home
Shila, it has been a pleasure to work with you over the past few months - so glad that you returned to the University of Sydney!
Alexandra Sharland retweeted
RNA floating in solution is partitioned into single-cell droplets along with cells. This ambient RNA confounds downstream analysis. Tools like SoupX and DecontX attempt to remove this background. Here are lung cells positive (yellow) for one gene before and after SoupX. 🧵(1/2)
Congratulations, @shazanfar and @stephaniehicks . Really looking forward to seeing the fruits of this work.
Extremely excited to work with @stephaniehicks on this CZI-funded project!! Thank you @cziscience for supporting data intensive single cell and spatial science 💯
Alexandra Sharland retweeted
Next Monday, we are thrilled to have @martinjzhang discuss the benefits of using scDRS. It can identify subpopulations of disease-associated cells not captured by existing cell-type labels, providing insight into schizophrenia and inflammatory bowel disease. Join us on Zoom!
Alexandra Sharland retweeted
How do T-cells eliminate harmful cells in cancer and infection?
Grantees @chevaliersf, @KrisLaukens + Benson Ogunjimi are developing a tool to functionally annotate groups of T-cells related to disease in existing #SingleCell data
Alexandra Sharland retweeted
What better way to celebrate #WorldKidneyDay2023 than kidney shaped shortbread!
Alexandra Sharland retweeted
What are the challenges of single cell multi-omics data integration and evaluation? Next Monday, @XiuweiZhang will present on two methods, scDisInFact and scMultiSim, which can overcome some of these issues. Join us on Zoom!
Alexandra Sharland retweeted
Very excited for @shazanfar to be back in Australia to give this talk for @NswSsa. Looking forward to the seminar!
Seminar announcement: Mosaic single-cell data integration by @shazanfar
⏲️ 6:30-7:30PM, 3rd Aug (Wed)
📍Sydney Uni Law Building, Seminar Room 105 and over Zoom
🔗 statsoc.org.au/event-4894759
🎉We are also running a door prize for members who turn up in person! Join us to win!
Alexandra Sharland retweeted
Alexandra Sharland retweeted
Almost at a whole 500 followers. Keep the momentum going. Join us next week as we put science on the agenda. Please RT, Please follow us. Its going to take everyone #EMCR #STEM #SaveOzScience @ResAustralia @Science_Academy @ScienceAU @natashamitchell @liammannix @ConversationEDU
Alexandra Sharland retweeted
Meet the student bringing Black illustrations to the medical field. nbcnews.to/3oLcSwJ
Alexandra Sharland retweeted
Very excited to share our work on using single-cell and spatial transcriptomics to study pathogenesis of viral myocarditis! We present time-course single-cell and spatial RNAseq datasets for ileum and heart tissue from reovirus infected neonatal mice. biorxiv.org/content/10.1101/…
Alexandra Sharland retweeted
The official TCRdist3 publication is here! Do you have lots of TCR sequencing in which you want to identify relevant specificity clusters? This is one-stop shopping. (1/5) elifesciences.org/articles/6…
Alexandra Sharland retweeted
Check it out! github.com/kmayerb/tcrdist3 Videos, great examples, you do not need to be an expert to get the code running. Led by Koshlan Mayer-Blackwell and @agartland, with @sschattgen, @Liel_Cohen_, @jeremycfd, @aanaishe, @TomerHertz & nontweeters Phil Bradley and Jessica Gaevert
Alexandra Sharland retweeted
Researchers discover a potential new therapeutic pathway to clear chronic viral infections. Congrats to @MonashBDI's A/Prof @KimLJacobson who led the study, findings published in @NatImmunol. Read the paper go.nature.com/3I4U1nF Thread 👇& full story: bit.ly/3D2R4k1
It is... B cells FTW day!
I am so, so happy to share our latest in @NatImmunol
We discovered that aberrant BMI-1 in B cells is key for poor antibody in chronic infection.
Targeting BMI-1 improved Ab quality & viral clearance @MonashBDI
Link: rdcu.be/cCheU
Alexandra Sharland retweeted
A tool leveraging RNA-seq to generate custom libraries to identify immune-related peptides missed by traditional databases - by Dr Kate Scull and Dr Kirti Pandey @tony_purcell8 @PurcellLab @immunity_BDI
"Immunopeptidogenomics: harnessing RNA-seq to illuminate the dark immunopeptidome"
@MonashUni @MonashBDI @Dr_Sri_Ram #immunopeptidogeniomics #MassSpec #TeamMassSpec
mcponline.org/article/S1535-…
Alexandra Sharland retweeted
Immunopeptidomics role now open at University of Dundee Spin-out company. See below for more information and to apply:
adlib-recruitment.co.uk/jobs…
#immunopeptidomics #cancer #antigendiscovery #massspectrometry



































