@3M_Lab

Single Molecule Biophysics

 Madrid, Spain
borjaibarralab.com
Joined March 2017
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We are delighted to share our collaborative work with Ibarra Lab @3M_Lab and Fernandez-Leiro Lab @rfleiro, in which we dissect autoregulatory mechanism of Twinkle helicase! Big thank you to Sjoerd Wanrooij @Wanrooij20 and other reviewers for a smooth process! @Greg_Ciesielski ; nature.com/articles/s41467-0…
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Excited to share our latest paper, published in Nature Communications! As first author from @3M_Lab, I’m proud of this collaborative effort with @LabMito and @rfleiro, where we dissect the autoregulatory mechanism of the mitochondrial helicase Twinkle. 🔗 nature.com/articles/s41467-0…

Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase

Nature Communications - The human mitochondrial helicase Twinkle is essential for maintaining mitochondrial DNA. Here, the authors combine biochemical and single-molecule approaches to show how...

nature.com
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Lamentamos que un medio como @elconfidencial donde escriben grandes periodistas, utilice una fuente inadecuada para informar del tiempo, haciendo pasar por meteorólogo a quien no lo es y fomentando el consumo de su contenido. En esto, o eres parte del problema o de la solución
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Estamos buscando con cierta urgencia candidatos con motivación e ilusión para solicitar un contrato predoctoral ligado a un proyecto de tesis doctoral en nuestro @GrupoBIOMIL, bien conectado con el mundo clínico y con el sector industrial. Más información: linkedin.com/posts/b%C3%A1rb…
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REGISTRATION OPEN - CNIO meeting, Machines acting on DNA and RNA, 2025 May 28-30th in Madrid, organized by @NogalesLab , @rfleiro , @LlorcaLab Bringing leaders in structural biology in Chromatin structure, DNA repair, RNA processing, Replication, Transcription and Translation.
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The #ESRWnano workshop will take place at @IMDEA_nano, but also online! Follow the hashtag #ESRWnano and check the posts in your favourite social media -all posts will be published in the website. 🟦🟩🟨🟧🟥 nanociencia.imdea.org/home-e…
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Check out the fruits of our wonderful collaboration with @3M_Lab and @rfleiro, @Greg_Ciesielski. Auto-regulation of the real-time kinetics of the human mitochondrial replicative helicase biorxiv.org/content/10.1101/…

Auto-regulation of the real-time kinetics of the human mitochondrial replicative helicase

The human mitochondrial replicative helicase, Twinkle, is essential for the replication and integrity of mitochondrial DNA (mtDNA). Therefore, investigating the real-time kinetics of Twinkle’s...

biorxiv.org
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Replying to @RSEQUIMICA @IMDEA_Nano
Enhorabuena crack!!!
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Replying to @CaixaResearch @rfleiro @FundlaCaixa @CNIOStopCancer @3mlaboratory @IMDEA_nano @CIB_CSIC
🤝Este proyecto #CaixaResearch, liderado por @rfleiro, se realiza en consorcio con: 👉Borja Ibarra Urruela, de @IMDEA_Nano 👉Cristina Ugalde Bilbao, de @CIB_CSIC
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🧬Errores en la replicación del ADN de las mitocondrias —un componente celular— se asocian a trastornos neurodegenerativos como el alzhéimer y el párkinson. Con una ayuda #CaixaResearch, @rfleiro investigará cómo contribuyen estos errores a las patologías, lo que permitirá desarrollar nuevas aproximaciones terapéuticas. tinyurl.com/5n7etfrr
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Researchers @IMDEA_Nano @CNB_CSIC @nanolsi @KanazawaUniv_O record the first "film" of the multiplication of the influenza A virus genome. 🎞️nanociencia.imdea.org/home-e… 1/4 #IMDEAnanoPublications #sciart @Scixel
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Six days left to apply to SMB 2025 in Aspen, CO. Lots of great single molecule biophysics in a spectacular location. For details on the meeting and the application process, see our web site: jila.colorado.edu/smb/ Please RT. -Aaron and Tom
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Borja Ibarra retweeted
Rafa F Leiro@rfleiro6 Sep 2024
A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 May 28th to 30th, 2025 - Save the date! @OscarLlorcaCNIO @rfleiro @NogalesLab
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Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.1101/…
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📢📢We are hiring! We're looking for a Postdoctoral Research Assistant to explore the dynamics of human mitochondrial DNA replication at the single-molecule level @IMDEA_Nano Review the details below👇or visit borjaibarralab.com 💻 Please RT 🙏🙏
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Researchers @IMDEA_nano @unistra led by @Hermanslab control -in real time- a chemical reaction network by light. 🔦nanociencia.imdea.org/home-e… 1/3 #IMDEAnanoPublications
Microscopy images of the reaction network producing fibers in a star-like shape. Credit: Jorge S. Valera.

ALT Microscopy images of the reaction network producing fibers in a star-like shape. Credit: Jorge S. Valera.

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Borja Ibarra retweeted
David Dulin@Dulin_Lab29 Aug 2024
Preprint alert from the lab!!! Huge congrats to the lead author Salina Quack and many thanks to our collaborators @yorgomodis, #WouterRoos, and @CBroedersz biorxiv.org/content/10.1101/… Buckle up for a long 🧵... 1/

An alternative mechanism for activation of innate immune signaling by MDA5

Long double-stranded (ds) RNA in the cytosol acts as a potent inflammatory molecule recognized by the receptor MDA5, triggering the innate immune response. Mutations in MDA5 affecting dsRNA recogni...

biorxiv.org
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Borja Ibarra retweeted
ACS Nano@acsnano24 Jul 2024
Scientists from @nanolsi @KanazawaUniv_O @IMDEA_Nano use high-speed atomic force microscopy and electron microscopy to study the conformational dynamics of individual #InfluenzaAvirus recombinant RNPs (rRNPs) during #RNASynthesis. @3M_Lab #OpenAccess: go.acs.org/afx
TOC image from the article

ALT TOC image from the article

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The first call deadline is fast approaching! Apply until the 23rd of August to the @IDEALcofund PhD Fellowships in Nanoscience. 🗺️📍@imdea_nano, Madrid 🇪🇸 👇Read about some of the projects 👇 The offer is great! idealcofund-project.eu/phd/p…
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📢Looking for PhD candidates interested in 👇 Uncovering the dynamics of synthetic molecular motors at the single-molecule level - IDEAL PhD Cofund (idealcofund-project.eu) 🧐Guide-for-applicants-IDEAL-PhD-Programme.pdf (idealcofund-project.eu)
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