Assistant professor @westlake_uni. Synthetic biology. Pilot (PPL, IR).
Joined June 2009
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Zibo Chen retweeted
Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!
😂
Finally a more intuitive way to learn pLDDT/pAE? 😎
sokrypton.github.io/protein_…
(Character idea from @HannesStaerk & Alex Waldherr)
Zibo Chen retweeted
🌱🚨 Very proud and excited to share our PREPRINT, unveiling an advance for plant science, biotech, & synthetic biology in the first (of many) Khalil <> Gehring collaborations!
biorxiv.org/content/10.64898…
New theory paper alert! Working with @chemaoxfz & led by the brilliant @zhuomao76, we wanted to see if kinetic proofreading (KPR) could be optimized at the multicellular level. Here is how we found a way to bypass one of biology's fundamental trade-offs: sciencedirect.com/science/ar…
While this is a theory paper for now, by pairing synthetic endocytic receptors with protein circuits, we are now trying to bring these high-fidelity networks to life in the wet lab. Stay tuned for what's next!
Finally, this beautiful illustration by @zhuomao76 & co. perfectly conveys the core message of our paper
Zibo Chen retweeted
🍹Long weekend Project: Since Claude Fable is banned for Science, I thought it might be fun to see if it can be used for something less scientific. 😎
Introducing Age of Epochs! ⚔️ An attempted reproduction of Age of Empires II in Javascript.
ageofepochs.com/
Zibo Chen retweeted
Longer thread later, but if you are designing small proteins or want to building a stability predictor using 1.8 million highly diverse experimental measurements… credit to @ChoYehlin and @KotaroTsuboyama !
biorxiv.org/content/10.64898…
Zibo Chen retweeted
I'm very excited to share that I've started a new position as a Group Leader at CZ Biohub NY! @biohub
Zibo Chen retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Zibo Chen retweeted
Join us next March'26 at
Synthetic biology for Health and Sustainability
Abstracts deadline: December 1st, 2025
Link below 👇
Great lineup of speakers and excellent venue: Kristala Prather (MIT), Luis Serrrano (CRG), Priscilla Briquez (Freiburg), Zibo Chen (Westlake U) @ZiboChen , Tobias Erb (Max Planck), Cleo Kontoravdi (Imperial College), Debora Marks (Harvard), Nicola Patron (U of Cambridge), Sai Reddy (ETH), Anna Rising (Karolinksa), Edda Schulz (Max Planck), Claudia Vickers (Queensland U), Chris Voigt (MIT) @Geneticdesigner, Harris Wang (Columbia)
Thrilled to share our new paper on MASS (Multivalent Antigen Sensing Simulator)!
We built a fast and accurate simulator to calculate multivalent binding KINETICS from monomeric properties, enabling sensing of cell surface antigen types and densities.
pubs.acs.org/doi/10.1021/jac…
We also optimized the code to be fast, so you're not waiting hours to simulate higher valency binding kinetics. Code is available here: github.com/BioProgramming-La…
Huge shoutout to @DamonRunyon for funding this work. And check out this stunning cover art by the unstoppable first author, Xiaoyu, with a Haiku interpretation from Gemini:
Small bots read the stone
Linked by glowing, sensing wire
Many arms see one
