Zhong Yan Gan (@zhongyangan) header
Zhong Yan Gan (@zhongyangan) profile picture

Zhong Yan Gan

@zhongyangan

Postdoc, Hegde Lab @MRC_LMB

 Cambridge, England
Joined October 2011
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Photo by Zhong Yan Gan (@zhongyangan)
Check out our latest paper in @ScienceAdvances! We reveal nucleotide-induced changes in PINK1 using cryo-EM, and investigated PINK1's interaction with reported PINK1 activating molecules KTP/kinetin. Grateful to @komander_lab @WEHI_research and other. science.org/doi/10.1126/scia…
Interaction of PINK1 with nucleotides and kinetin

Interaction of PINK1 with nucleotides and kinetin

PINK1-nucleotide complexes reveal kinase plasticity and explain why a gatekeeper mutation is required for PINK1 to use KTP.

science.org
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An excellent opportunity is available for a Research Officer (Postdoc) to join the Komander lab in the Ubiquitin Signalling Division. Applications close 19 May 2023. For further details and to apply: wehi.wd3.myworkdayjobs.com/e…
Image from WEHI (Walter and Eliza Hall Institute) (@WEHI_research)
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Zhong Yan Gan retweeted
entactbio (@entactbio) profile picture
entactbio@entactbio6 Dec 2022
1/ We’re thrilled to announce that we've raised $81 million in Series A financing to advance our proprietary platform for developing enhancement-targeting chimeric molecules, or ENTACs: precision medicines designed to enhance the function of key proteins. entactbio.com/entact-bio-lau…
Image from entactbio (@entactbio)
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NSMB Research Highlights this month shine the spotlight on mitochondria. #1 "PINK spots: diseased mitochondria prepare for mitophagy" discusses 2 papers in @Nature & @MolecularCell by @komander_lab @gl_alisa &al and @jftrempe &al on PINK1 activation mech nature.com/articles/s41594-0…
Image from NatureStructMolBiol (@NatureSMB)
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Released today @EMDB_EMPIAR & @PDBeurope, & published @Nature, the 2.5 Å #SingleParticle #CryoEM structure of a dodecameric, unphosphorylated #PINK1 mutant; 1/5 maps that helped elucidate the activation mechanism of this #ProteinKinase involved in early onset #ParkinsonsDisease
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The first major publication of the @LechtenbergLab, by @therealtcotts “Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216”, is out now in @MolecularCell. Read here: authors.elsevier.com/a/1eNZ%… #ubiquitin #neurodegeneration
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WEHI researchers have visualised the entire process that leads to the activation of PINK1 – a protein directly linked to #Parkinsons disease. The blueprint could help in developing much-needed new treatments to slow or halt progression of the disease. wehi.edu.au/news/parkinsons-…
Image from WEHI (Walter and Eliza Hall Institute) (@WEHI_research)
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Delighted to share our paper on PINK1, now out in @Nature. We structurally characterised the entire activation mechanism of PINK1 using crystallography and cryo-EM. Thank you to everyone who contributed! @komander_lab @WEHI_research rdcu.be/cDDHl nature.com/articles/s41586-0…
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And couldn't have been possible without @gl_alisa and her cryo-EM skills!
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Zhong Yan Gan retweeted
Grant Dewson (@DewsonGrant) profile picture
Grant Dewson@DewsonGrant1 Nov 2021
Looking forward to hearing from David Komander @komander_lab @WEHI_research on the control of PINK1 and Parkin in #mitochondria clearance and #Parkinsonsdisease. Friday 5th Nov 11am AEDT. us02web.zoom.us/j/8781915379… Webinar: 878 1915 3794 Passcode: 581533
Image from Grant Dewson (@DewsonGrant)
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